Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

EMBO Reports

Volumn 14, Issue 11, 2013, Pages 992-998

  Herold, Marco J ^a,b   Rohrbeck, Leona ^a,b   Lang, Mathias J ^a,b,d   Grumont, Raelene ^c   Gerondakis, Steve ^c   Tai, Lin ^a,b   Bouillet, Philippe ^a,b   Kaufmann, Thomas ^a,e   Strasser, Andreas ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF BASEL   (Switzerland)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

apoptosis; Bcl 2; BH3 only proteins; Bim; hematopoiesis

Indexed keywords

BIM PROTEIN; DEXAMETHASONE; INTERLEUKIN 7; IONOMYCIN; TAMOXIFEN; TRANSCRIPTION FACTOR FOXO;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BINDING SITE; CELL SURVIVAL; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GRANULOCYTE; HEMATOPOIETIC CELL; HEMATOPOIETIC SYSTEM; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; UPREGULATION;

MUS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; BINDING SITES; CARCINOGENESIS; CELL DEATH; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; HEK293 CELLS; HEMATOPOIESIS; HEMATOPOIETIC SYSTEM; HUMANS; LYMPHOMA; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; THYMOCYTES; TRANSCRIPTION, GENETIC;

EID: 84887118565     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.152     Document Type: Article

References (27)

1. Strasser A, O'Connor L, Dixit VM (2000) Apoptosis signaling. Ann Rev Biochem 69: 217-245
2. Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9: 505-512
3. Youle RJ, Strasser A (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59
4. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DCS (1998) Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17: 384-395
5. Bouillet P, Metcalf D, Huang DCS, Tarlinton DM, Kay TWH, Köntgen F, Adams JM, Strasser A (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738
6. Erlacher M, Laabi V, Manzl C, Bock G, Tzankov A, Haecker G, Strasser A, Villunger A (2006) Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med 203: 2939-2951
7. Bouillet P et al (2002) BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926
8. Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A (2003) Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreative B cells. J Exp Med 198: 1119-1126
9. Pellegrini M, Belz G, Bouillet P, Strasser A (2003) Shut down of an acute T cell immune response to viral infection is mediated by the pro-apoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci USA 100: 14175-14180
10. Fischer SF, Bouillet P, O'Donnell K, Light A, Tarlinton DM, Strasser A (2007) Pro-apoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody forming cells. Blood 110: 3978-3984
11. Dijkers PF, Birkenkamp KU, Lam EW, Thomas NS, Lammers JW, Koenderman L, Coffer PJ (2002) FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol 156: 531-542
12. Dijkers PF, Medema RH, Lammers JJ, Koenderman L, Coffer PJ (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10: 1201-1204
13. Kip1 and Bim in response to IL-2. J Immunol 168: 5024-5031
14. Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162: 613-622
15. Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre HJ, Sutherland GR, Adams JM (2001) Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mamm Genome 12: 163-168
16. Pellegrini M, Bouillet P, Robati M, Belz GT, Davey GM, Strasser A (2004) Loss of Bim increases T cell production and function in Interleukin 7 receptor-deficient mice. J Exp Med 200: 1189-1195
17. Fu Z, Tindall DJ (2008) FOXOs, cancer and regulation of apoptosis. Oncogene 27: 2312-2319
18. /~ mice. Cell 89: 1011-1019
19. Strasser A, Pellegrini M (2004) T-lymphocyte death during shutdown of an immune response. Trends Immunol 25: 610-615
20. Moller C, Alfredsson J, Engstrom M, Wootz H, Xiang Z, Lennartsson J, Jonsson JI, Nilsson G (2005) Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood 106: 1330-1336
21. Cragg MS, Harris C, Strasser A, Scott CL (2009) Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer 9: 321-326
22. Egle A, Harris AW, Bouillet P, Cory S (2004) Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 101: 6164-6169
23. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318: 533-538
24. Strasser A (2005) The role of BH3-only proteins in the immune system. Nat Rev Immunol 5: 189-200
25. Ventura A et al (2008) Targeted deletion reveals essential and overlapping functions of the mIR-17~92 family of miRNA clusters. Cell 132: 875-886
26. You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, Villunger A, Mak TW (2006) FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med 203: 1657-1663
27. Ekoff M, Kaufmann T, Engstrom M, Motoyama N, Villunger A, Jonsson JI, Strasser A, Nilsson G (2007) The BH3-only protein Puma plays an essential role in cytokine deprivation-induced apoptosis of mast cells. Blood 110: 3209-3217