A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice

Journal of Immunology

Volumn 190, Issue 1, 2013, Pages 147-158

  Kortum, Robert L ^a   Rouquette Jazdanian, Alexandre K ^a   Miyaji, Michihiko ^a,c   Merrill, Robert K ^a   Markegard, Evan ^b   Pinski, John M ^a   Wesselink, Amelia ^a   Nath, Nandan N ^a   Alexander, Clayton P ^a   Li, Wenmei ^a   Kedei, Noemi ^a   Roose, Jeroen P ^b   Blumberg, Peter M ^a   Samelson, Lawrence E ^a   Sommers, Connie L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; LAT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE C THETA; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN RASGRP1; RAS PROTEIN; SOS PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DEATH; ENZYME ACTIVATION; IN VIVO STUDY; LYMPHOPROLIFERATIVE DISEASE; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GERM-LINE MUTATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISORDERS; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS;

EID: 84871837348     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201458     Document Type: Article

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