Markov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement

PLoS Computational Biology

Volumn 11, Issue 7, 2015, Pages

  Jiang, Hanlun ^a,b   Sheong, Fu Kit ^a   Zhu, Lizhe ^a,b,c   Gao, Xin ^d   Bernauer, Julie ^e   Huang, Xuhui ^a,b,c  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b HKUST SHENZHEN RESEARCH INSTITUTE   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^d KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

^e ECOLE POLYTECHNIQUE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PROTEINS;

ARGONAUTE PROTEINS; CELLULAR MECHANISMS; CENTRAL COMPONENT; DYNAMICS SIMULATION; GENE SILENCING; MARKOV STATE MODELS; RE-ARRANGEMENT; RNA INTERFERENCE; SELECTIVE BINDING; TWO-STEP MECHANISMS;

RNA;

ARGONAUTE PROTEIN; MICRORNA; EIF2C2 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; MARKOV STATE MODEL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; STATISTICAL CONCEPTS; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; HUMAN; MARKOV CHAIN; PROTEIN CONFORMATION; STATISTICAL MODEL; ULTRASTRUCTURE;

ARGONAUTE PROTEINS; BINDING SITES; HUMANS; MARKOV CHAINS; MICRORNAS; MODELS, CHEMICAL; MODELS, STATISTICAL; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84938651561     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004404     Document Type: Article

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