Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 28, 2014, Pages 10197-10202

  Greives, Nicholas ^a   Zhou, Huan Xiang ^a  

^a Florida State University   (United States)

Author keywords

Conformational dynamics; Diffusion influenced bimolecular reaction; Induced fit fraction; Protein ligand complex

Indexed keywords

LIGAND;

ARTICLE; BINDING KINETICS; CONCENTRATION (PARAMETERS); CONCEPTUAL FRAMEWORK; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIFFUSION; GENETIC SELECTION; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; SIMULATION;

CONFORMATIONAL DYNAMICS; DIFFUSION-INFLUENCED BIMOLECULAR REACTION; INDUCED-FIT FRACTION; PROTEIN-LIGAND COMPLEX;

KINETICS; LIGANDS; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; PROTEINS;

EID: 84904291286     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1407545111     Document Type: Article

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