메뉴 건너뛰기




Volumn 59, Issue 8, 2015, Pages 1431-1442

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner

Author keywords

Hyperglycaemia; Insulin resistance; PTP1B; Resveratrol; Sirt1

Indexed keywords

MUS;

EID: 84938556978     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400933     Document Type: Article
Times cited : (59)

References (55)
  • 1
    • 0242380324 scopus 로고    scopus 로고
    • Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?
    • Reusch, J. E., Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? J. Clin. Invest. 2003, 112, 986-988.
    • (2003) J. Clin. Invest. , vol.112 , pp. 986-988
    • Reusch, J.E.1
  • 2
    • 0037191135 scopus 로고    scopus 로고
    • Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities
    • LeRoith, D., Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am. J. Med. 2002, 113 (Suppl 6A), 3S-11S.
    • (2002) Am. J. Med. , vol.113 , pp. 3S-11S
    • LeRoith, D.1
  • 3
    • 33947373424 scopus 로고    scopus 로고
    • Glucotoxicity inhibits late steps of insulin exocytosis
    • Dubois, M., Vacher, P., Roger, B., Huyghe, D. et al., Glucotoxicity inhibits late steps of insulin exocytosis. Endocrinology 2007, 148, 1605-1614.
    • (2007) Endocrinology , vol.148 , pp. 1605-1614
    • Dubois, M.1    Vacher, P.2    Roger, B.3    Huyghe, D.4
  • 4
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers, D. J., Burks, D. J., Towery, H. H., Altamuro, S. L. et al., Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat. Genet. 1999, 23, 32-40.
    • (1999) Nat. Genet. , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4
  • 5
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • Withers, D. J., Gutierrez, J. S., Towery, H., Burks, D. J. et al., Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998, 391, 900-904.
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1    Gutierrez, J.S.2    Towery, H.3    Burks, D.J.4
  • 6
    • 0042822138 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes
    • Valverde, A. M., Burks, D. J., Fabregat, I., Fisher, T. L. et al., Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes 2003, 52, 2239-2248.
    • (2003) Diabetes , vol.52 , pp. 2239-2248
    • Valverde, A.M.1    Burks, D.J.2    Fabregat, I.3    Fisher, T.L.4
  • 7
    • 77950366124 scopus 로고    scopus 로고
    • Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice
    • Gonzalez-Rodriguez, A., Mas Gutierrez, J. A., Sanz-Gonzalez, S., Ros, M. et al., Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes 2010, 59, 588-599.
    • (2010) Diabetes , vol.59 , pp. 588-599
    • Gonzalez-Rodriguez, A.1    Mas Gutierrez, J.A.2    Sanz-Gonzalez, S.3    Ros, M.4
  • 9
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur, J. A., Sinclair, D. A., Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5, 493-506.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 10
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • Brasnyo, P., Molnar, G. A., Mohas, M., Marko, L. et al., Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br. J. Nutr. 2011, 106, 383-389.
    • (2011) Br. J. Nutr. , vol.106 , pp. 383-389
    • Brasnyo, P.1    Molnar, G.A.2    Mohas, M.3    Marko, L.4
  • 11
    • 84857501565 scopus 로고    scopus 로고
    • Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents
    • Kang, W., Hong, H. J., Guan, J., Kim, D. G. et al., Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents. Metabolism 2012, 61, 424-433.
    • (2012) Metabolism , vol.61 , pp. 424-433
    • Kang, W.1    Hong, H.J.2    Guan, J.3    Kim, D.G.4
  • 12
    • 38649132291 scopus 로고    scopus 로고
    • Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
    • Saiko, P., Szakmary, A., Jaeger, W., Szekeres, T., Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat. Res. 2008, 658, 68-94.
    • (2008) Mutat. Res. , vol.658 , pp. 68-94
    • Saiko, P.1    Szakmary, A.2    Jaeger, W.3    Szekeres, T.4
  • 13
    • 79954632388 scopus 로고    scopus 로고
    • Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes
    • Lee, S. M., Yang, H., Tartar, D. M., Gao, B. et al., Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. Diabetologia 2011, 54, 1136-1146.
    • (2011) Diabetologia , vol.54 , pp. 1136-1146
    • Lee, S.M.1    Yang, H.2    Tartar, D.M.3    Gao, B.4
  • 14
    • 84887937515 scopus 로고    scopus 로고
    • Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms
    • Kumar, A., Negi, G., Sharma, S. S., Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms. Curr. Med. Chem. 2013, 20, 4640-4645.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 4640-4645
    • Kumar, A.1    Negi, G.2    Sharma, S.S.3
  • 16
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A. et al., Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3    Jamieson, H.A.4
  • 17
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    • Sun, C., Zhang, F., Ge, X., Yan, T. et al., SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 2007, 6, 307-319.
    • (2007) Cell Metab. , vol.6 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4
  • 18
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P. et al., Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434, 113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4
  • 19
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • Haigis, M. C., Guarente, L. P., Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006, 20, 2913-2921.
    • (2006) Genes Dev. , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 20
    • 78650758398 scopus 로고    scopus 로고
    • Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
    • Herranz, D., Munoz-Martin, M., Canamero, M., Mulero, F. et al., Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat. Commun. 2010, 1, 3.
    • (2010) Nat. Commun. , vol.1 , pp. 3
    • Herranz, D.1    Munoz-Martin, M.2    Canamero, M.3    Mulero, F.4
  • 21
    • 78649482634 scopus 로고    scopus 로고
    • SIRT1: recent lessons from mouse models
    • Herranz, D., Serrano, M., SIRT1: recent lessons from mouse models. Nat. Rev. Cancer 2010, 10, 819-823.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 819-823
    • Herranz, D.1    Serrano, M.2
  • 23
    • 79961090786 scopus 로고    scopus 로고
    • High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression
    • Andersen, G., Burkon, A., Sulzmaier, F. J., Walker, J. M. et al., High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression. Mol. Nutr. Food Res. 2011, 55, 1197-1206.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1197-1206
    • Andersen, G.1    Burkon, A.2    Sulzmaier, F.J.3    Walker, J.M.4
  • 24
    • 79958110487 scopus 로고    scopus 로고
    • Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control
    • Dao, T. M., Waget, A., Klopp, P., Serino, M. et al., Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. PLoS One 2011, 6, e20700.
    • (2011) PLoS One , vol.6 , pp. e20700
    • Dao, T.M.1    Waget, A.2    Klopp, P.3    Serino, M.4
  • 25
    • 33746862126 scopus 로고    scopus 로고
    • Resveratrol inhibits insulin responses in a SirT1-independent pathway
    • Zhang, J., Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem. J. 2006, 397, 519-527.
    • (2006) Biochem. J. , vol.397 , pp. 519-527
    • Zhang, J.1
  • 26
    • 84876486772 scopus 로고    scopus 로고
    • Role of endogenous IL-6 in the neonatal expansion and functionality of Wistar rat pancreatic alpha cells
    • Fernandez-Millan, E., de Toro-Martin, J., Lizarraga-Mollinedo, E., Escriva, F., Alvarez, C., Role of endogenous IL-6 in the neonatal expansion and functionality of Wistar rat pancreatic alpha cells. Diabetologia 2013, 56, 1098-1107.
    • (2013) Diabetologia , vol.56 , pp. 1098-1107
    • Fernandez-Millan, E.1    de Toro-Martin, J.2    Lizarraga-Mollinedo, E.3    Escriva, F.4    Alvarez, C.5
  • 27
    • 84862777315 scopus 로고    scopus 로고
    • Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging
    • Gonzalez-Rodriguez, A., Mas-Gutierrez, J. A., Mirasierra, M., Fernandez-Perez, A. et al., Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. Aging Cell 2012, 11, 284-296.
    • (2012) Aging Cell , vol.11 , pp. 284-296
    • Gonzalez-Rodriguez, A.1    Mas-Gutierrez, J.A.2    Mirasierra, M.3    Fernandez-Perez, A.4
  • 28
    • 84900812119 scopus 로고    scopus 로고
    • Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
    • Li, M., Lu, Y., Hu, Y., Zhai, X. et al., Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats. Toxicol. Lett. 2014, 228, 67-74.
    • (2014) Toxicol. Lett. , vol.228 , pp. 67-74
    • Li, M.1    Lu, Y.2    Hu, Y.3    Zhai, X.4
  • 29
    • 80555142897 scopus 로고    scopus 로고
    • Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
    • Schenk, S., McCurdy, C. E., Philp, A., Chen, M. Z. et al., Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J. Clin. Invest. 2011, 121, 4281-4288.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4281-4288
    • Schenk, S.1    McCurdy, C.E.2    Philp, A.3    Chen, M.Z.4
  • 30
    • 48249085391 scopus 로고    scopus 로고
    • Oxidative stress as a major culprit in kidney disease in diabetes
    • Forbes, J. M., Coughlan, M. T., Cooper, M. E., Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008, 57, 1446-1454.
    • (2008) Diabetes , vol.57 , pp. 1446-1454
    • Forbes, J.M.1    Coughlan, M.T.2    Cooper, M.E.3
  • 32
    • 77952551952 scopus 로고    scopus 로고
    • Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: prophylactic role of arjunolic acid
    • Manna, P., Das, J., Ghosh, J., Sil, P. C., Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: prophylactic role of arjunolic acid. Free Radic. Biol. Med. 2010, 48, 1465-1484.
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 1465-1484
    • Manna, P.1    Das, J.2    Ghosh, J.3    Sil, P.C.4
  • 33
    • 2342514015 scopus 로고    scopus 로고
    • An important role of Nrf2-ARE pathway in the cellular defense mechanism
    • Lee, J. M., Johnson, J. A., An important role of Nrf2-ARE pathway in the cellular defense mechanism. J. Biochem. Mol. Biol. 2004, 37, 139-143.
    • (2004) J. Biochem. Mol. Biol. , vol.37 , pp. 139-143
    • Lee, J.M.1    Johnson, J.A.2
  • 34
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H. et al., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127, 1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3    Meziane, H.4
  • 35
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • Um, J. H., Park, S. J., Kang, H., Yang, S. et al., AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010, 59, 554-563.
    • (2010) Diabetes , vol.59 , pp. 554-563
    • Um, J.H.1    Park, S.J.2    Kang, H.3    Yang, S.4
  • 36
    • 34249071951 scopus 로고    scopus 로고
    • Glucose enhances protein tyrosine phosphatase 1B gene transcription in hepatocytes
    • Inada, S., Ikeda, Y., Suehiro, T., Takata, H. et al., Glucose enhances protein tyrosine phosphatase 1B gene transcription in hepatocytes. Mol. Cell Endocrinol. 2007, 271, 64-70.
    • (2007) Mol. Cell Endocrinol. , vol.271 , pp. 64-70
    • Inada, S.1    Ikeda, Y.2    Suehiro, T.3    Takata, H.4
  • 37
    • 62749115187 scopus 로고    scopus 로고
    • Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
    • Delibegovic, M., Zimmer, D., Kauffman, C., Rak, K. et al., Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes 2009, 58, 590-599.
    • (2009) Diabetes , vol.58 , pp. 590-599
    • Delibegovic, M.1    Zimmer, D.2    Kauffman, C.3    Rak, K.4
  • 38
    • 17644424349 scopus 로고    scopus 로고
    • Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice
    • Haj, F. G., Zabolotny, J. M., Kim, Y. B., Kahn, B. B., Neel, B. G., Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J. Biol. Chem. 2005, 280, 15038-15046.
    • (2005) J. Biol. Chem. , vol.280 , pp. 15038-15046
    • Haj, F.G.1    Zabolotny, J.M.2    Kim, Y.B.3    Kahn, B.B.4    Neel, B.G.5
  • 39
    • 0029762957 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase 1B interacts with the activated insulin receptor
    • Seely, B. L., Staubs, P. A., Reichart, D. R., Berhanu, P. et al., Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes 1996, 45, 1379-1385.
    • (1996) Diabetes , vol.45 , pp. 1379-1385
    • Seely, B.L.1    Staubs, P.A.2    Reichart, D.R.3    Berhanu, P.4
  • 40
    • 84888800151 scopus 로고    scopus 로고
    • Resveratrol modulates autophagy and NF-kappaB activity in a murine model for treating non-alcoholic fatty liver disease
    • Li, L., Hai, J., Li, Z., Zhang, Y. et al., Resveratrol modulates autophagy and NF-kappaB activity in a murine model for treating non-alcoholic fatty liver disease. Food Chem. Toxicol. 2013, 63, 166-173.
    • (2013) Food Chem. Toxicol. , vol.63 , pp. 166-173
    • Li, L.1    Hai, J.2    Li, Z.3    Zhang, Y.4
  • 41
    • 84874008167 scopus 로고    scopus 로고
    • Resveratrol attenuates oxidative stress induced by balloon injury in the rat carotid artery through actions on the ERK1/2 and NF-kappa B pathway
    • Zhang, J., Chen, J., Yang, J., Xu, C. W. et al., Resveratrol attenuates oxidative stress induced by balloon injury in the rat carotid artery through actions on the ERK1/2 and NF-kappa B pathway. Cell Physiol. Biochem. 2013, 31, 230-241.
    • (2013) Cell Physiol. Biochem. , vol.31 , pp. 230-241
    • Zhang, J.1    Chen, J.2    Yang, J.3    Xu, C.W.4
  • 42
    • 47249148827 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    • Zabolotny, J. M., Kim, Y. B., Welsh, L. A., Kershaw, E. E. et al., Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J. Biol. Chem. 2008, 283, 14230-14241.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14230-14241
    • Zabolotny, J.M.1    Kim, Y.B.2    Welsh, L.A.3    Kershaw, E.E.4
  • 43
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • Canto, C., Auwerx, J., PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol. 2009, 20, 98-105.
    • (2009) Curr. Opin. Lipidol. , vol.20 , pp. 98-105
    • Canto, C.1    Auwerx, J.2
  • 44
    • 84878885257 scopus 로고    scopus 로고
    • Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice
    • White, A. T., McCurdy, C. E., Philp, A., Hamilton, D. L. et al., Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia 2013, 56, 1629-1637.
    • (2013) Diabetologia , vol.56 , pp. 1629-1637
    • White, A.T.1    McCurdy, C.E.2    Philp, A.3    Hamilton, D.L.4
  • 45
    • 79955661493 scopus 로고    scopus 로고
    • Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    • Li, Y., Xu, S., Giles, A., Nakamura, K. et al., Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J. 2011, 25, 1664-1679.
    • (2011) FASEB J. , vol.25 , pp. 1664-1679
    • Li, Y.1    Xu, S.2    Giles, A.3    Nakamura, K.4
  • 46
    • 84899498150 scopus 로고    scopus 로고
    • The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
    • Caron, A. Z., He, X., Mottawea, W., Seifert, E. L. et al., The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J. 2014, 28, 1306-1316.
    • (2014) FASEB J. , vol.28 , pp. 1306-1316
    • Caron, A.Z.1    He, X.2    Mottawea, W.3    Seifert, E.L.4
  • 47
    • 63449112017 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    • Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S. et al., Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 2009, 9, 327-338.
    • (2009) Cell Metab. , vol.9 , pp. 327-338
    • Purushotham, A.1    Schug, T.T.2    Xu, Q.3    Surapureddi, S.4
  • 48
    • 80555146753 scopus 로고    scopus 로고
    • Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
    • Wang, R. H., Kim, H. S., Xiao, C., Xu, X. et al., Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J. Clin. Invest. 2011, 121, 4477-4490.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4477-4490
    • Wang, R.H.1    Kim, H.S.2    Xiao, C.3    Xu, X.4
  • 49
    • 67650488877 scopus 로고    scopus 로고
    • SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
    • Erion, D. M., Yonemitsu, S., Nie, Y., Nagai, Y. et al., SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. USA 2009, 106, 11288-11293.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 11288-11293
    • Erion, D.M.1    Yonemitsu, S.2    Nie, Y.3    Nagai, Y.4
  • 50
    • 52749091816 scopus 로고    scopus 로고
    • SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    • Banks, A. S., Kon, N., Knight, C., Matsumoto, M. et al., SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008, 8, 333-341.
    • (2008) Cell Metab. , vol.8 , pp. 333-341
    • Banks, A.S.1    Kon, N.2    Knight, C.3    Matsumoto, M.4
  • 51
    • 54849425547 scopus 로고    scopus 로고
    • Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    • Feige, J. N., Lagouge, M., Canto, C., Strehle, A. et al., Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008, 8, 347-358.
    • (2008) Cell Metab. , vol.8 , pp. 347-358
    • Feige, J.N.1    Lagouge, M.2    Canto, C.3    Strehle, A.4
  • 52
    • 84903478895 scopus 로고    scopus 로고
    • Redox regulation of antioxidant enzymes: post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver
    • Sadi, G., Bozan, D., Yildiz, H. B., Redox regulation of antioxidant enzymes: post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver. Mol. Cell Biochem. 2014, 393, 111-122.
    • (2014) Mol. Cell Biochem. , vol.393 , pp. 111-122
    • Sadi, G.1    Bozan, D.2    Yildiz, H.B.3
  • 53
    • 84871255763 scopus 로고    scopus 로고
    • Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model
    • Zhang, C., Lu, X., Tan, Y., Li, B. et al., Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model. PLoS One 2012, 7, e49257.
    • (2012) PLoS One , vol.7 , pp. e49257
    • Zhang, C.1    Lu, X.2    Tan, Y.3    Li, B.4
  • 54
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: insights into their biological function
    • Michan, S., Sinclair, D., Sirtuins in mammals: insights into their biological function. Biochem. J. 2007, 404, 1-13.
    • (2007) Biochem. J. , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 55
    • 33744480316 scopus 로고    scopus 로고
    • NAD+ and NADH in cellular functions and cell death
    • Ying, W., NAD+ and NADH in cellular functions and cell death. Front Biosci. 2006, 11, 3129-3148.
    • (2006) Front Biosci. , vol.11 , pp. 3129-3148
    • Ying, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.