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Volumn 56, Issue 7, 2013, Pages 1629-1637

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

Author keywords

2 Deoxyglucose uptake; Energy restriction; Insulin sensitivity; SIRT1; Skeletal muscle

Indexed keywords

ADENYLATE KINASE; DEOXYGLUCOSE; GLUCOSE; INSULIN; ISOPHANE INSULIN; MESSENGER RNA; SIRTUIN 1;

EID: 84878885257     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2912-2     Document Type: Article
Times cited : (42)

References (34)
  • 1
    • 0035132672 scopus 로고    scopus 로고
    • Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    • 11194248 10.2337/diacare.24.1.89 1:CAS:528:DC%2BD3MXkvVKlug%3D%3D
    • Weyer C, Tataranni PA, Bogardus C, Pratley RE (2001) Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 24:89-94
    • (2001) Diabetes Care , vol.24 , pp. 89-94
    • Weyer, C.1    Tataranni, P.A.2    Bogardus, C.3    Pratley, R.E.4
  • 2
    • 77953631698 scopus 로고    scopus 로고
    • The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways
    • 20007326 10.1210/er.2009-0026 1:CAS:528:DC%2BC3cXmtlSgs7w%3D
    • Houtkooper RH, Canto C, Wanders RJ, Auwerx J (2010) The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev 31:194-223
    • (2010) Endocr Rev , vol.31 , pp. 194-223
    • Houtkooper, R.H.1    Canto, C.2    Wanders, R.J.3    Auwerx, J.4
  • 3
    • 77952876986 scopus 로고    scopus 로고
    • Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
    • 20026274 10.1016/j.phrs.2009.12.006 1:CAS:528:DC%2BC3cXmtFahu74%3D
    • Yu J, Auwerx J (2010) Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation. Pharmacol Res 62:35-41
    • (2010) Pharmacol Res , vol.62 , pp. 35-41
    • Yu, J.1    Auwerx, J.2
  • 4
    • 52749091816 scopus 로고    scopus 로고
    • SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    • 18840364 10.1016/j.cmet.2008.08.014 1:CAS:528:DC%2BD1cXht1Cit77L
    • Banks AS, Kon N, Knight C et al (2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8:333-341
    • (2008) Cell Metab , vol.8 , pp. 333-341
    • Banks, A.S.1    Kon, N.2    Knight, C.3
  • 5
    • 36248975293 scopus 로고    scopus 로고
    • SIRT1 transgenic mice show phenotypes resembling calorie restriction
    • 17877786 10.1111/j.1474-9726.2007.00335.x 1:CAS:528:DC%2BD2sXhsVeksbbJ
    • Bordone L, Cohen D, Robinson A et al (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6:759-767
    • (2007) Aging Cell , vol.6 , pp. 759-767
    • Bordone, L.1    Cohen, D.2    Robinson, A.3
  • 6
    • 54849425547 scopus 로고    scopus 로고
    • Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    • 19046567 10.1016/j.cmet.2008.08.017 1:CAS:528:DC%2BD1cXhtlOgur7O
    • Feige JN, Lagouge M, Canto C et al (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8:347-358
    • (2008) Cell Metab , vol.8 , pp. 347-358
    • Feige, J.N.1    Lagouge, M.2    Canto, C.3
  • 7
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • 18046409 10.1038/nature06261 1:CAS:528:DC%2BD2sXhtlKmtbrM
    • Milne JC, Lambert PD, Schenk S et al (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716
    • (2007) Nature , vol.450 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3
  • 8
    • 79951726016 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
    • 21241768 10.1016/j.mce.2011.01.008
    • Frojdo S, Durand C, Molin L et al (2011) Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Mol Cell Endocrinol 335:166-176
    • (2011) Mol Cell Endocrinol , vol.335 , pp. 166-176
    • Frojdo, S.1    Durand, C.2    Molin, L.3
  • 9
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    • 17908559 10.1016/j.cmet.2007.08.014 1:CAS:528:DC%2BD2sXht1Sjsr3L
    • Sun C, Zhang F, Ge X et al (2007) SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 6:307-319
    • (2007) Cell Metab , vol.6 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3
  • 10
    • 80555142897 scopus 로고    scopus 로고
    • Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
    • 21985785 10.1172/JCI58554 1:CAS:528:DC%2BC3MXhsVCksLzP
    • Schenk S, McCurdy CE, Philp A et al (2011) Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest 121:4281-4288
    • (2011) J Clin Invest , vol.121 , pp. 4281-4288
    • Schenk, S.1    McCurdy, C.E.2    Philp, A.3
  • 11
    • 0028225771 scopus 로고
    • Glucose transport with brief dietary restriction: Heterogenous responses in muscles
    • 8023926 1:CAS:528:DyaK2cXltlSkt7g%3D
    • Cartee GD, Dean DJ (1994) Glucose transport with brief dietary restriction: heterogenous responses in muscles. Am J Physiol 266:E946-E952
    • (1994) Am J Physiol , vol.266
    • Cartee, G.D.1    Dean, D.J.2
  • 12
    • 17844401269 scopus 로고    scopus 로고
    • Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle
    • 15855319 10.2337/diabetes.54.5.1349 1:CAS:528:DC%2BD2MXktVCks7s%3D
    • McCurdy CE, Cartee GD (2005) Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle. Diabetes 54:1349-1356
    • (2005) Diabetes , vol.54 , pp. 1349-1356
    • McCurdy, C.E.1    Cartee, G.D.2
  • 13
    • 44849096876 scopus 로고    scopus 로고
    • The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    • 18414679 10.1371/journal.pone.0002020
    • Firestein R, Blander G, Michan S et al (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3:e2020
    • (2008) PLoS One , vol.3 , pp. 2020
    • Firestein, R.1    Blander, G.2    Michan, S.3
  • 14
    • 40949146900 scopus 로고    scopus 로고
    • Normal hypertrophy accompanied by phosphorylation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
    • McGee SL, Mustard KJ, Hardie DG, Baar K (2008) Normal hypertrophy accompanied by phosphorylation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586:1731-1741
    • (2008) J Physiol , vol.586 , pp. 1731-1741
    • McGee, S.L.1    Mustard, K.J.2    Hardie, D.G.3    Baar, K.4
  • 15
    • 73649120921 scopus 로고    scopus 로고
    • Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
    • 19887594 10.1152/ajpendo.00524.2009 1:CAS:528:DC%2BC3cXhsFKmtLg%3D
    • Bruss MD, Khambatta CF, Ruby MA, Aggarwal I, Hellerstein MK (2010) Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates. Am J Physiol Endocrinol Metab 298:E108-E116
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Bruss, M.D.1    Khambatta, C.F.2    Ruby, M.A.3    Aggarwal, I.4    Hellerstein, M.K.5
  • 16
    • 77953292238 scopus 로고    scopus 로고
    • SIRT1 and p53, effect on cancer, senescence and beyond
    • 20471503 10.1016/j.bbapap.2010.05.002 1:CAS:528:DC%2BC3cXntlaltbY%3D
    • Yi J, Luo J (2010) SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta 1804:1684-1689
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1684-1689
    • Yi, J.1    Luo, J.2
  • 17
    • 77349087078 scopus 로고    scopus 로고
    • SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
    • 19996381 10.1152/ajpendo.00417.2009 1:CAS:528:DC%2BC3cXjsFGgs7g%3D
    • Yoshizaki T, Schenk S, Imamura T et al (2010) SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 298:E419-E428
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Yoshizaki, T.1    Schenk, S.2    Imamura, T.3
  • 18
    • 61749095297 scopus 로고    scopus 로고
    • SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
    • 19103747 10.1128/MCB.00705-08 1:CAS:528:DC%2BD1MXitlylsrY%3D
    • Yoshizaki T, Milne JC, Imamura T et al (2009) SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 29:1363-1374
    • (2009) Mol Cell Biol , vol.29 , pp. 1363-1374
    • Yoshizaki, T.1    Milne, J.C.2    Imamura, T.3
  • 19
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • 22395709 10.1038/nm.2627 1:CAS:528:DC%2BC38Xjt1OrtLc%3D
    • Osborn O, Olefsky JM (2012) The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18:363-374
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 20
    • 79957639938 scopus 로고    scopus 로고
    • Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats
    • 21386065 10.1152/ajpendo.00659.2010 1:CAS:528:DC%2BC3MXot1Cgu7k%3D
    • Sharma N, Arias EB, Bhat AD et al (2011) Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats. Am J Physiol Endocrinol Metab 300:E966-E978
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Sharma, N.1    Arias, E.B.2    Bhat, A.D.3
  • 21
    • 84864062918 scopus 로고    scopus 로고
    • Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism
    • 22811431 10.1152/physrev.00022.2011 1:CAS:528:DC%2BC38Xht1KmtbbP
    • Nogueiras R, Habegger KM, Chaudhary N et al (2012) Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev 92:1479-1514
    • (2012) Physiol Rev , vol.92 , pp. 1479-1514
    • Nogueiras, R.1    Habegger, K.M.2    Chaudhary, N.3
  • 22
    • 84856554652 scopus 로고    scopus 로고
    • The role of SirT1 in muscle mitochondrial turnover
    • 21406254 10.1016/j.mito.2011.03.001 1:CAS:528:DC%2BC38XhvVOltrg%3D
    • Menzies KJ, Hood DA (2012) The role of SirT1 in muscle mitochondrial turnover. Mitochondrion 12:5-13
    • (2012) Mitochondrion , vol.12 , pp. 5-13
    • Menzies, K.J.1    Hood, D.A.2
  • 24
    • 45549098657 scopus 로고    scopus 로고
    • SirT1 regulates energy metabolism and response to caloric restriction in mice
    • 18335035 10.1371/journal.pone.0001759
    • Boily G, Seifert EL, Bevilacqua L et al (2008) SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One 3:e1759
    • (2008) PLoS One , vol.3 , pp. 1759
    • Boily, G.1    Seifert, E.L.2    Bevilacqua, L.3
  • 25
    • 77956644726 scopus 로고    scopus 로고
    • SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
    • 20620997 10.1016/j.cmet.2010.05.010 1:CAS:528:DC%2BC3cXptFKqs7w%3D
    • Ramadori G, Fujikawa T, Fukuda M et al (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab 12:78-87
    • (2010) Cell Metab , vol.12 , pp. 78-87
    • Ramadori, G.1    Fujikawa, T.2    Fukuda, M.3
  • 26
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
    • 18687677 10.1074/jbc.M805711200 1:CAS:528:DC%2BD1cXhtF2hsLnM
    • Lan F, Cacicedo JM, Ruderman N, Ido Y (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283:27628-27635
    • (2008) J Biol Chem , vol.283 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.M.2    Ruderman, N.3    Ido, Y.4
  • 27
    • 57849131142 scopus 로고    scopus 로고
    • Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
    • 19071085 10.1016/j.bbrc.2008.11.130 1:CAS:528:DC%2BD1cXhsFClsb3P
    • Suchankova G, Nelson LE, Gerhart-Hines Z et al (2009) Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun 378:836-841
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 836-841
    • Suchankova, G.1    Nelson, L.E.2    Gerhart-Hines, Z.3
  • 28
    • 50649112638 scopus 로고    scopus 로고
    • SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    • 18482975 10.1074/jbc.M802187200 1:CAS:528:DC%2BD1cXotlOitL0%3D
    • Hou X, Xu S, Maitland-Toolan KA et al (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem 283:20015-20026
    • (2008) J Biol Chem , vol.283 , pp. 20015-20026
    • Hou, X.1    Xu, S.2    Maitland-Toolan, K.A.3
  • 29
    • 67349276169 scopus 로고    scopus 로고
    • AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    • 19262508 10.1038/nature07813 1:CAS:528:DC%2BD1MXivVKltLc%3D
    • Canto C, Gerhart-Hines Z, Feige JN et al (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458:1056-1060
    • (2009) Nature , vol.458 , pp. 1056-1060
    • Canto, C.1    Gerhart-Hines, Z.2    Feige, J.N.3
  • 30
    • 77249156847 scopus 로고    scopus 로고
    • Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
    • 20197054 10.1016/j.cmet.2010.02.006 1:CAS:528:DC%2BC3cXlsVaju78%3D
    • Canto C, Jiang LQ, Deshmukh AS et al (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab 11:213-219
    • (2010) Cell Metab , vol.11 , pp. 213-219
    • Canto, C.1    Jiang, L.Q.2    Deshmukh, A.S.3
  • 31
    • 77952940043 scopus 로고    scopus 로고
    • Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
    • 20157566 1:CAS:528:DC%2BD1MXht1Gku7%2FF
    • Palacios OM, Carmona JJ, Michan S et al (2009) Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging 1:771-783
    • (2009) Aging , vol.1 , pp. 771-783
    • Palacios, O.M.1    Carmona, J.J.2    Michan, S.3
  • 32
    • 84860561281 scopus 로고    scopus 로고
    • Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle
    • 22396207 10.2337/db11-1180 1:CAS:528:DC%2BC38Xmtlyhtrw%3D
    • Wang P, Zhang RY, Song J et al (2012) Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 61:1051-1061
    • (2012) Diabetes , vol.61 , pp. 1051-1061
    • Wang, P.1    Zhang, R.Y.2    Song, J.3
  • 33
    • 6044239443 scopus 로고    scopus 로고
    • Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity
    • 15251868 10.1152/ajpendo.00172.2004 1:CAS:528:DC%2BD2cXhtVaqs7nK
    • Gonzalez AA, Kumar R, Mulligan JD, Davis AJ, Weindruch R, Saupe KW (2004) Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am J Physiol Endocrinol Metab 287:E1032-E1037
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Gonzalez, A.A.1    Kumar, R.2    Mulligan, J.D.3    Davis, A.J.4    Weindruch, R.5    Saupe, K.W.6
  • 34
    • 80052193535 scopus 로고    scopus 로고
    • Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise
    • 21757760 10.1074/jbc.M111.261685 1:CAS:528:DC%2BC3MXhtVOkt7fF
    • Philp A, Chen A, Lan D et al (2011) Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem 286:30561-30570
    • (2011) J Biol Chem , vol.286 , pp. 30561-30570
    • Philp, A.1    Chen, A.2    Lan, D.3


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