Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats

Toxicology Letters

Volumn 228, Issue 2, 2014, Pages 67-74

  Li, Mingzhu ^a   Lu, Yang ^a   Hu, Yan ^a   Zhai, Xiaohan ^a   Xu, Wei ^a   Jing, Huirong ^a   Tian, Xiaofeng ^a   Lin, Yuan ^a   Gao, Dongyan ^a   Yao, Jihong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Ethanol; Liver injury; P53; Salvianolic acid B; SIRT1

Indexed keywords

ALCOHOL; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MALONALDEHYDE; PROTEIN BCL XL; PROTEIN P53; SALVIANOLIC ACID B; SIRTUIN 1; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; B CELL LYMPHOMA; CELL VIABILITY; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; HEPG2 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; LIVER HISTOLOGY; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; UPREGULATION;

ETHANOL; LIVER INJURY; P53; SALVIANOLIC ACID B; SIRT1;

ACETYLATION; ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BENZOFURANS; BLOTTING, WESTERN; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOKINES; DRUG-INDUCED LIVER INJURY; ETHANOL; GLUTATHIONE; IMMUNOPRECIPITATION; LIVER; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84900812119     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.04.011     Document Type: Article

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