Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice

Free Radical Biology and Medicine

Volumn 87, Issue , 2015, Pages 15-25

  Xu, Guoshun ^a,b   Wu, Hongying ^a   Zhang, Junling ^a   Li, Deguan ^a   Wang, Yueying ^a   Wang, Yingying ^a,c   Zhang, Heng ^a   Lu, Lu ^a   Li, Chengcheng ^a,c   Huang, Song ^a   Xing, Yonghua ^a   Zhou, Daohong ^a,c   Meng, Aimin ^a,d  

^a INSTITUTE OF RADIATION MEDICINE   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d BEIJING HOSPITAL   (China)

Author keywords

Free radicals; Hematopoietic stem cells; Ionizing radiation; Metformin; Oxidative stress; Radioprotection

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; HISTONE H2AX; METFORMIN; RADIOPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; ANTIOXIDANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW INJURY; CELL DAMAGE; CONTROLLED STUDY; DNA DAMAGE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION PROTECTION; SENESCENCE; UPREGULATION; WHOLE BODY RADIATION; ANIMAL; CELL AGING; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; RADIATION RESPONSE;

MUS;

ANIMALS; ANTIOXIDANTS; CELL AGING; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; HEMATOPOIETIC STEM CELLS; HUMANS; METFORMIN; MICE; OXIDATIVE STRESS; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; WHOLE-BODY IRRADIATION;

EID: 84938352729     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.05.045     Document Type: Article

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