-
1
-
-
39749183343
-
Analysis of mortality rates for pancreatic cancer across the world
-
Hariharan D, Saied A, Kocher HM. Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford) 2008; 10:58-62.
-
(2008)
HPB (Oxford)
, vol.10
, pp. 58-62
-
-
Hariharan, D.1
Saied, A.2
Kocher, H.M.3
-
2
-
-
79958043675
-
-
editors. Bethesda: National Cancer Institute
-
SEER Cancer Statistics Review, 1975-2009. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou, R, Altekruse SF, et al., editors. Bethesda: National Cancer Institute; 2012.
-
(2012)
SEER Cancer Statistics Review 1975-2009
-
-
Howlader, N.1
Noone, A.M.2
Krapcho, M.3
Neyman, N.4
Aminou, R.5
Altekruse, S.F.6
-
3
-
-
84904122326
-
Failure of pancreatic cancer chemotherapy: Consequences of drug resistance mechanisms
-
Srivastava SK, editor Rijeka, Croatia: In Tech
-
Bhardwaj V, Tadinada MS, Lai CK, Bhushan A. Failure of pancreatic cancer chemotherapy: consequences of drug resistance mechanisms. In: Srivastava SK, editor. Pancreatic cancer. molecular mechanism and targets. Rijeka, Croatia: InTech; 2012. p. 144-60.
-
(2012)
Pancreatic Cancer. Molecular Mechanism and Targets
, pp. 144-160
-
-
Bhardwaj, V.1
Tadinada, M.S.2
Lai, C.K.3
Bhushan, A.4
-
4
-
-
0344394514
-
Insulin and longevity: Antidiabetic biguanides as geroprotectors
-
Anisimov VN, Semenchenko AV, Yashin AI. Insulin and longevity: antidiabetic biguanides as geroprotectors. Biogerontology 2003; 4:297-307.
-
(2003)
Biogerontology
, vol.4
, pp. 297-307
-
-
Anisimov, V.N.1
Semenchenko, A.V.2
Yashin, A.I.3
-
5
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27:3576-86.
-
(2008)
Oncogene
, vol.27
, pp. 3576-3586
-
-
Ben Sahra, I.1
Laurent, K.2
Loubat, A.3
Giorgetti-Peraldi, S.4
Colosetti, P.5
Auberger, P.6
-
6
-
-
0038410183
-
An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress
-
Bonnefont-Rousselot D, Raji B, Walrand S, Gardes-Albert M, Jore D, Legrand A, et al. An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 2003; 52:586-9.
-
(2003)
Metabolism
, vol.52
, pp. 586-589
-
-
Bonnefont-Rousselot, D.1
Raji, B.2
Walrand, S.3
Gardes-Albert, M.4
Jore, D.5
Legrand, A.6
-
7
-
-
0017843134
-
Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats
-
Dilman VM, Berstein LM, Zabezhinski MA, Alexandrov VA, Bobrov JF, Pliss GB. Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch 1978; 48:1-8.
-
(1978)
Arch Geschwulstforsch
, vol.48
, pp. 1-8
-
-
Dilman, V.M.1
Berstein, L.M.2
Zabezhinski, M.A.3
Alexandrov, V.A.4
Bobrov, J.F.5
Pliss, G.B.6
-
8
-
-
33746592505
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin: Response to Farooki and Schneider
-
Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin: Response to Farooki and Schneider. Diabetes Care 2006; 29:1990-1.
-
(2006)
Diabetes Care
, vol.29
, pp. 1990-1991
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
9
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005; 330:1304-5.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
10
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67:6745-52.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
Deberardinis, R.J.5
Zhao, F.6
-
11
-
-
0035082644
-
Prevention of pancreatic cancer induction in hamsters by metformin
-
Schneider MB, Matsuzaki H, Haorah J, Ulrich A, Standop J, Ding XZ, et al. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 2001; 120:1263-70.
-
(2001)
Gastroenterology
, vol.120
, pp. 1263-1270
-
-
Schneider, M.B.1
Matsuzaki, H.2
Haorah, J.3
Ulrich, A.4
Standop, J.5
Ding, X.Z.6
-
12
-
-
84877353837
-
Metformin use and improved response to therapy in esophageal adenocarcinoma
-
Skinner HD, McCurdy MR, Echeverria AE, Lin SH, Welsh JW, O'Reilly MS, et al. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol 2013; 52:1002-9.
-
(2013)
Acta Oncol
, vol.52
, pp. 1002-1009
-
-
Skinner, H.D.1
McCurdy, M.R.2
Echeverria, A.E.3
Lin, S.H.4
Welsh, J.W.5
O'Reilly, M.S.6
-
13
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009; 69:7507-11.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
14
-
-
79955490053
-
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
-
Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res 2011; 71:3196-201.
-
(2011)
Cancer Res
, vol.71
, pp. 3196-3201
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
15
-
-
84860196738
-
Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
-
Song CW, Lee H, Dings RP, Williams B, Powers J, Santos TD, et al. Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. Sci Rep 2012; 2:362.
-
(2012)
Sci Rep
, vol.2
, pp. 362
-
-
Song, C.W.1
Lee, H.2
Dings, R.P.3
Williams, B.4
Powers, J.5
Santos, T.D.6
-
16
-
-
77955917717
-
Ionizing radiation activates AMP-activated kinase (AMPK): A target for radiosensitization of human cancer cells
-
Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys 2012; 78:221-9.
-
(2012)
Int J Radiat Oncol Biol Phys
, vol.78
, pp. 221-229
-
-
Sanli, T.1
Rashid, A.2
Liu, C.3
Harding, S.4
Bristow, R.G.5
Cutz, J.C.6
-
17
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108:1167-74.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
-
18
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMPactivated protein kinase cascade
-
Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMPactivated protein kinase cascade. Biochem J 2007; 403:139-48.
-
(2007)
Biochem J
, vol.403
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
Hegarty, B.D.3
Snowden, M.A.4
Carling, D.5
-
19
-
-
0037366196
-
Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells
-
Zielske SP, Gerson SL. Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells. Mol Ther 2003; 7:325-33.
-
(2003)
Mol Ther
, vol.7
, pp. 325-333
-
-
Zielske, S.P.1
Gerson, S.L.2
-
20
-
-
79959764729
-
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
-
Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P, et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 2011; 71:4366-72.
-
(2011)
Cancer Res
, vol.71
, pp. 4366-4372
-
-
Ben Sahra, I.1
Regazzetti, C.2
Robert, G.3
Laurent, K.4
Le Marchand-Brustel, Y.5
Auberger, P.6
-
21
-
-
0030005273
-
Radiosensitization of pancreatic cancer cells by 20,20-difluoro-20- deoxycytidine
-
Lawrence TS, Chang EY, Hahn TM, Hertel LW, Shewach DS. Radiosensitization of pancreatic cancer cells by 20,20-difluoro-20-deoxycytidine. Int J Radiat Oncol Biol Phys 1996; 34:867-72.
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.34
, pp. 867-872
-
-
Lawrence, T.S.1
Chang, E.Y.2
Hahn, T.M.3
Hertel, L.W.4
Shewach, D.S.5
-
22
-
-
58149354390
-
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
-
Zhuang Y, Miskimins WK. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. J Mol Signal 2008; 3:18.
-
(2008)
J Mol Signal
, vol.3
, pp. 18
-
-
Zhuang, Y.1
Miskimins, W.K.2
-
23
-
-
0036324142
-
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
-
Hawley SA, Gadalla AE, Olsen GS, Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 2002; 51:2420-5.
-
(2002)
Diabetes
, vol.51
, pp. 2420-2425
-
-
Hawley, S.A.1
Gadalla, A.E.2
Olsen, G.S.3
Hardie, D.G.4
-
24
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 3:214-26.
-
(2008)
Mol Cell
, vol.3
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
25
-
-
0029009953
-
Risk of pancreatic cancer following diabetes mellitus: A nationwide cohort study in Sweden
-
Chow WH, Gridley G, Nyren O, Linet MS, Ekbom A, Fraumeni JF Jr., et al. Risk of pancreatic cancer following diabetes mellitus: a nationwide cohort study in Sweden. J Natl Cancer Inst 1995; 87:930-1.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 930-931
-
-
Chow, W.H.1
Gridley, G.2
Nyren, O.3
Linet, M.S.4
Ekbom, A.5
Fraumeni Jr., J.F.6
-
26
-
-
0029017953
-
Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis
-
Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. J Am Med Assoc 1995; 273:1605-9.
-
(1995)
J Am Med Assoc
, vol.273
, pp. 1605-1609
-
-
Everhart, J.1
Wright, D.2
-
28
-
-
67650945180
-
Antidiabetic therapies affect risk of pancreatic cancer
-
Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 2009; 137:482-8.
-
(2009)
Gastroenterology
, vol.137
, pp. 482-488
-
-
Li, D.1
Yeung, S.C.2
Hassan, M.M.3
Konopleva, M.4
Abbruzzese, J.L.5
-
29
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310:1642-6.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
-
30
-
-
33847072201
-
AMP-activated protein kinase as a drug target
-
Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 2007; 47:185-210.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 185-210
-
-
Hardie, D.G.1
-
31
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1:15-25.
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
33
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006; 126:955-68.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
-
34
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115:577-90.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
35
-
-
67650514082
-
Metformin induces unique biological and molecular responses in triple negative breast cancer cells
-
Liu B, Fan Z, Edgerton SM, Deng XS, Alimova IN, Lind SE, et al. Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle 2009; 8:2031-40.
-
(2009)
Cell Cycle
, vol.8
, pp. 2031-2040
-
-
Liu, B.1
Fan, Z.2
Edgerton, S.M.3
Deng, X.S.4
Alimova, I.N.5
Lind, S.E.6
-
36
-
-
81855185407
-
5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells
-
Isebaert SF, Swinnen JV, McBride WH, Begg AC, Haustermans KM. 5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells. Int J Radiat Oncol Biol Phys 2011; 81:1515-23.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.81
, pp. 1515-1523
-
-
Isebaert, S.F.1
Swinnen, J.V.2
McBride, W.H.3
Begg, A.C.4
Haustermans, K.M.5
-
37
-
-
79955642725
-
Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response
-
Vazquez-Martin A, Oliveras-Ferraros C, Cufi S, Martin-Castillo B, Menendez JA. Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response. Cell Cycle 2011; 10:1499-501.
-
(2011)
Cell Cycle
, vol.10
, pp. 1499-1501
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Cufi, S.3
Martin-Castillo, B.4
Menendez, J.A.5
-
38
-
-
84878561961
-
Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
-
Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, et al. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 2013; 108:2021-32.
-
(2013)
Br J Cancer
, vol.108
, pp. 2021-2032
-
-
Storozhuk, Y.1
Hopmans, S.N.2
Sanli, T.3
Barron, C.4
Tsiani, E.5
Cutz, J.C.6
-
39
-
-
79955839356
-
IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway
-
Duan X, Ponomareva L, Veeranki S, Choubey D. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PloS One 2011; 6:e19532.
-
(2011)
PloS One
, vol.6
-
-
Duan, X.1
Ponomareva, L.2
Veeranki, S.3
Choubey, D.4
-
40
-
-
80855165212
-
Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling
-
Halicka HD, Zhao H, Li J, Traganos F, Zhang S, Lee M, et al. Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling. Aging 2011; 3:1028-38.
-
(2011)
Aging
, vol.3
, pp. 1028-1038
-
-
Halicka, H.D.1
Zhao, H.2
Li, J.3
Traganos, F.4
Zhang, S.5
Lee, M.6
-
41
-
-
84877259011
-
Low concentrations of metformin selectively inhibit CD133(\+) cell proliferation in pancreatic cancer and have anticancer action
-
Gou S, Cui P, Li X, Shi P, Liu T, Wang C. Low concentrations of metformin selectively inhibit CD133(\+) cell proliferation in pancreatic cancer and have anticancer action. PLoS One 2013; 8:e63969.
-
(2013)
PLoS One
, vol.8
-
-
Gou, S.1
Cui, P.2
Li, X.3
Shi, P.4
Liu, T.5
Wang, C.6
|