Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes

Oncology Reports

Volumn 9, Issue 6, 2002, Pages 1307-1312

  Miyazaki, Junichi ^a   Hokari, Ryota ^a   Kato, Shingo ^a   Tsuzuki, Yoshikazu ^a   Kawaguchi, Atushi ^a   Nagao, Shigeaki ^a   Itoh, Kazuro ^a   Miura, Soichiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Galectin 3; Gastric cancer; Immunohistochemistry; Lymph node metastasis

Indexed keywords

GALECTIN 3;

ADENOCARCINOMA; ARTICLE; CANCER STAGING; CELL DIFFERENTIATION; COLLOID CARCINOMA; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; HUMAN; LYMPH NODE; LYMPH NODE METASTASIS; METABOLISM; METASTASIS; PAPILLARY CARCINOMA; PATHOLOGY; PROGNOSIS; SIGNET RING CARCINOMA; STOMACH TUMOR;

ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; CARCINOMA, PAPILLARY; CARCINOMA, SIGNET RING CELL; CELL DIFFERENTIATION; GALECTIN 3; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHATIC METASTASIS; NEOPLASM STAGING; PROGNOSIS; STOMACH NEOPLASMS;

EID: 0036835054     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.6.1307     Document Type: Article

References (26)

1. Barondes SH, Cooper DN, Gitt MA and Leffler H: Galectins. Structure and function of a large family of animal lectins. J Biol Chem269: 20807-20810, 1994.
2. Barondes SH, Castronovo V, Cooper DN, et ai. Galectins: a family of animal beta-galastoside-binding lectins. Cell 76: 597-598, 1994.
3. Woo HJ, Shaw LM, Messier JM and Mercurio AM: The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2). J Biol Chem 265: 7097-7099, 1990.
4. Ohannesian DW, Lotan D, Thomas P, et al: Carcinoembrionic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells. Cancer Res 55: 2191-2199, 1995.
5. Ochieng J, Leite-Browning ML and Warfield P: Regulation of cellular adhesion to extracellular matrix proteins by galectin-3. Biochem Biophys Res Commun 246: 788-791, 1998. (Pubitemid 28420936)
6. Wang L, Inohara H, Pienta KJ and Ratz A: Galectin-3 is a nuclear matrix protein which binds RNA. Biochem Biophys Res Commun 217: 292-303, 1995. (Pubitemid 26004793)
7. Dagher SF, Wang JL and Patterson RJ: Identification of galectin-3 as a factor in re-mRNA splicing. Proc Natl Acad Sci USA 92: 1213-1217, 1995.
8. Inohara H, Akahani S and Ratz A: Galectin 3 stimulates cell proliferation. Exp Cell Res 245: 294-302, 1998.
9. Yang RY, Hsu DK and Liu FT: Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci USA 93: 6737-6742, 1996. (Pubitemid 26230379)
10. Akahani S, Nangia-Makker P, Inohara H, Kim HR and Raz A: Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res 57: 5272-5276, 1997. (Pubitemid 27516362)
11. Lotz MM, Andrews CW Jr, Korzelius CA, et al: Decreased expression of Mac-2 (carbohydrate binding protein 35) and of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc Natl Acad Sei USA 90: 3466-3470, 1993. (Pubitemid 23111387)
12. Schoeppner HL, Raz A, Ho SB and Bresalier RS: Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon. Cancer 75: 2818-2826, 1995.
13. Hsu DK, Dowling CA, Jeng KC, et al: Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int J Cancer 81: 519-526, 1999. (Pubitemid 29203046)
14. Berberat PO, Friess H, Wang L, et al: Comparative analysis of galectins in primary tumors and tumor metastasis in human pancreatic cancer. J Histochem Cytochem 49: 539-549, 2001. (Pubitemid 32295176)
15. Orlandi F, Saggiorato E, Pivano G, et al: Galectin-3 is a presurgical marker of human thyroid carcinoma. Cancer Res 58: 3015-3020, 1998. (Pubitemid 28335081)
16. Van den Brule FA, Waltregny D, Liu FT and Castronovo V: Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate cancer progression. Int J Cancer 89: 361-367, 2000. (Pubitemid 30620290)
17. Idikio H: Galectin-3 expression in human breast carcinoma: correlation with cancer histologic grade. Int J Oncol 12: 1287-1290, 1998.
18. Lotan R, Ito H, Yasui W, et al: Expression of a31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary metastatic gastric carcinomas. Int J Cancer 56: 474-480, 1994. (Pubitemid 24094396)
19. Baldus SE, Zirbes TK, Weingarten M, et al: Increased galectin-3 expression in gastric cancer: correlation with histopathological subtypes, galactosylated antigens and tumor cell proliferation. Tumour Biol 21: 258-266, 2000. (Pubitemid 30666030)
20. Woo HJ, Joo HG, Song SW, Sohn YS and Chae C: Immunohisto-chemical detection of galectin-3 in canine gastric caricinomas. J Comp Pathol 124: 216-218, 2001.
21. Konstantinov KN, Robbins BA and Liu FT: Galectin-3, a beta-galactoside-binding animal lectin, is a marker of anaplasitic large-cell lymphoma. Am J Pathol 148: 5-30, 1996.
22. Jia S and Wang JL: Carbohydrate binding protein 35. Complementary DNA sequence reveals homology with proteins of the heterogeneous nuclear RNP. J Biol Chem 263: 6009-6011, 1988.
23. Raz A, Zhu D, Hogan V, et al: Evidence for the role of the 34-kDa galactoside-binding lectin in transformation and metastasis. Int J Cancer 46: 871-877, 1990.
24. Moutsatsos IK, Wade M, Schindler M and Wang JL: Endogeneous lectins from cultured cells: nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts. Proc Natl Acad Sei USA 84: 6452-6456, 1987.
25. Nangia-Makker P, Sarvis R, Visscher DW, et al: Galectin-3 and LI retrotransposons in human breast carcinomas. Breast Cancer Res Treat 49: 171-183, 1998. (Pubitemid 28279595)
26. Japanese Gastric Cancer Association: Japanese Classification of Gastric Carcinoma. 2nd English edition. Gastric Cancer 1: 10-24, 1998.