Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease

Nature Genetics

Volumn 47, Issue 6, 2015, Pages 640-642

  Li, Alexander H ^a   Morrison, Alanna C ^a   Kovar, Christie ^b   Cupples, L Adrienne ^c,d   Brody, Jennifer A ^e   Polfus, Linda M ^a   Yu, Bing ^a   Metcalf, Ginger ^b   Muzny, Donna ^b   Veeraraghavan, Narayanan ^b   Liu, Xiaoming ^a   Lumley, Thomas ^e,f   Mosley, Thomas H ^g   Gibbs, Richard A ^b   Boerwinkle, Eric ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c FRAMINGHAM HEART STUDY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

^g UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DNA; GLUCOSE; MAGNESIUM; TRIACYLGLYCEROL;

AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EXOME; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE LOCUS; GENE REPLICATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HEREDITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LOSS OF FUNCTION MUTATION; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; ATHEROSCLEROSIS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HUMAN GENOME; MOLECULAR GENETICS; RISK FACTOR;

ATHEROSCLEROSIS; CHRONIC DISEASE; EXOME; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; MOLECULAR SEQUENCE ANNOTATION; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84930092220     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3270     Document Type: Article

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