메뉴 건너뛰기




Volumn 7, Issue , 2015, Pages 225-239

New and emerging factors in tumorigenesis: An overview

Author keywords

Cancer; Gene mutations; Genomics; Metastasis; Targeted therapy resistance; Tumor heterogeneity

Indexed keywords

APC PROTEIN; B RAF KINASE; CD135 ANTIGEN; DNA METHYLTRANSFERASE 3A; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ISOCITRATE DEHYDROGENASE 2; NUCLEOPHOSMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; PROTEIN P53; PUMA PROTEIN; TAMOXIFEN; TRANSCRIPTION FACTOR GATA 3; TUMOR MARKER; VON HIPPEL LINDAU PROTEIN;

EID: 84938327409     PISSN: None     EISSN: 11791322     Source Type: Journal    
DOI: 10.2147/CMAR.S47797     Document Type: Article
Times cited : (32)

References (114)
  • 2
    • 84965187257 scopus 로고
    • The age distribution of cancer and a multi-stage theory of carcinogenesis
    • Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer. 1954;8(1):1–12.
    • (1954) Br J Cancer , vol.8 , Issue.1 , pp. 1-12
    • Armitage, P.1    Doll, R.2
  • 3
    • 4344646902 scopus 로고    scopus 로고
    • Species- and cell type-specific requirements for cellular transformation
    • Rangarajan A, Hong SJ, Gifford A, Weinberg RA. Species- and cell type-specific requirements for cellular transformation. Cancer Cell. 2004;6(2):171–183.
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 171-183
    • Rangarajan, A.1    Hong, S.J.2    Gifford, A.3    Weinberg, R.A.4
  • 4
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61(5):759–767.
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2(5):561–566.
    • (1996) Nat Med , vol.2 , Issue.5 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 7
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561–566.
    • (2007) Nature , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 8
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693–1703.
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 9
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366(9496):1527–1537.
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 11
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F, et al. Mutational landscape and significance across 12 major cancer types. Nature. 2013;502(7471): 333–339.
    • (2013) Nature , vol.502 , Issue.7471 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3
  • 12
    • 84884419292 scopus 로고    scopus 로고
    • Emerging patterns of somatic mutations in cancer
    • Watson IR, Takahashi K, Futreal PA, Chin L. Emerging patterns of somatic mutations in cancer. Nat Rev Genet. 2013;14(10): 703–718.
    • (2013) Nat Rev Genet , vol.14 , Issue.10 , pp. 703-718
    • Watson, I.R.1    Takahashi, K.2    Futreal, P.A.3    Chin, L.4
  • 13
    • 75549090214 scopus 로고    scopus 로고
    • Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    • Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract. 2009;205(12):858–862.
    • (2009) Pathol Res Pract , vol.205 , Issue.12 , pp. 858-862
    • Neumann, J.1    Zeindl-Eberhart, E.2    Kirchner, T.3    Jung, A.4
  • 14
    • 77956805993 scopus 로고    scopus 로고
    • KRAS gene mutations in lung cancer: Particulars established and issues unresolved
    • Okudela K, Woo T, Kitamura H. KRAS gene mutations in lung cancer: particulars established and issues unresolved. Pathol Int. 2010;60(10):651–660.
    • (2010) Pathol Int , vol.60 , Issue.10 , pp. 651-660
    • Okudela, K.1    Woo, T.2    Kitamura, H.3
  • 15
    • 42449114966 scopus 로고    scopus 로고
    • Transcriptional control of human p53-regulated genes
    • Riley T, Sontag E, Chen P, Levine A. Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol. 2008;9(5):402–412.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.5 , pp. 402-412
    • Riley, T.1    Sontag, E.2    Chen, P.3    Levine, A.4
  • 16
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75(4):817–825.
    • (1993) Cell , vol.75 , Issue.4 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 17
    • 0031987277 scopus 로고    scopus 로고
    • Regulation of p53 downstream genes
    • el-Deiry WS. Regulation of p53 downstream genes. Semin Cancer Biol. 1998;8(5):345–357.
    • (1998) Semin Cancer Biol , vol.8 , Issue.5 , pp. 345-357
    • El-Deiry, W.S.1
  • 18
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001;7(3):683–694.
    • (2001) Mol Cell , vol.7 , Issue.3 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 19
    • 33746883125 scopus 로고    scopus 로고
    • P53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction
    • Moll UM, Marchenko N, Zhang XK. p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction. Oncogene. 2006;25(34):4725–4743.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4725-4743
    • Moll, U.M.1    Marchenko, N.2    Zhang, X.K.3
  • 20
    • 53649084026 scopus 로고    scopus 로고
    • Orhon I, et al. P53 represses autophagy in a cell cycle-dependent fashion
    • Tasdemir E, Maiuri MC, Orhon I, et al. p53 represses autophagy in a cell cycle-dependent fashion. Cell Cycle. 2008;7(19):3006–3011.
    • (2008) Cell Cycle , vol.7 , Issue.19 , pp. 3006-3011
    • Tasdemir, E.1    Maiuri, M.C.2
  • 21
    • 65949083750 scopus 로고    scopus 로고
    • Cytoplasmic functions of the tumour suppressor p53
    • Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature. 2009;458(7242):1127–1130.
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1127-1130
    • Green, D.R.1    Kroemer, G.2
  • 23
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441(7092):424–430.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 24
    • 38749092231 scopus 로고    scopus 로고
    • Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase
    • Carson JD, Van Aller G, Lehr R, et al. Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase. Biochem J. 2008;409(2):519–524.
    • (2008) Biochem J , vol.409 , Issue.2 , pp. 519-524
    • Carson, J.D.1    Van Aller, G.2    Lehr, R.3
  • 25
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009;9(8):550–562.
    • (2009) Nat Rev Cancer , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 26
    • 48649092117 scopus 로고    scopus 로고
    • High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer
    • Simi L, Pratesi N, Vignoli M, et al. High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer. Am J Clin Pathol. 2008;130(2):247–253.
    • (2008) Am J Clin Pathol , vol.130 , Issue.2 , pp. 247-253
    • Simi, L.1    Pratesi, N.2    Vignoli, M.3
  • 27
    • 84905259995 scopus 로고    scopus 로고
    • Alliance for Clinical Trials in Oncology. Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147
    • Gonsalves WI, Mahoney MR, Sargent DJ, et al; Alliance for Clinical Trials in Oncology. Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147. J Natl Cancer Inst. 2014;106(7).
    • (2014) J Natl Cancer Inst , vol.106 , Issue.7
    • Gonsalves, W.I.1    Mahoney, M.R.2    Sargent, D.J.3
  • 28
    • 84864396450 scopus 로고    scopus 로고
    • Clear cell carcinoma of the ovary: A review of the literature
    • del Carmen MG, Birrer M, Schorge JO. Clear cell carcinoma of the ovary: a review of the literature. Gynecol Oncol. 2012;126(3):481–490.
    • (2012) Gynecol Oncol , vol.126 , Issue.3 , pp. 481-490
    • Del Carmen, M.G.1    Birrer, M.2    Schorge, J.O.3
  • 29
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • TCGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61–70.
    • (2012) Nature , vol.490 , Issue.7418 , pp. 61-70
  • 30
    • 84908460595 scopus 로고    scopus 로고
    • Cancer Genome Atlas Research Network. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
    • Hoadley KA, Yau C, Wolf DM, et al; Cancer Genome Atlas Research Network. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 2014;158(4):929–944.
    • (2014) Cell , vol.158 , Issue.4 , pp. 929-944
    • Hoadley, K.A.1    Yau, C.2    Wolf, D.M.3
  • 31
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • TCGA. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014;511(7511):543–550.
    • (2014) Nature , vol.511 , Issue.7511 , pp. 543-550
  • 32
    • 18344380088 scopus 로고    scopus 로고
    • P53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas
    • Singh B, Reddy PG, Goberdhan A, et al. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev. 2002;16(8):984–993.
    • (2002) Genes Dev , vol.16 , Issue.8 , pp. 984-993
    • Singh, B.1    Reddy, P.G.2    Goberdhan, A.3
  • 33
    • 84862815940 scopus 로고    scopus 로고
    • PTEN in DNA damage repair
    • Ming M, He YY. PTEN in DNA damage repair. Cancer Lett. 2012; 319(2):125–129.
    • (2012) Cancer Lett , vol.319 , Issue.2 , pp. 125-129
    • Ming, M.1    He, Y.Y.2
  • 34
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • Mayo LD, Donner DB. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci. 2002;27(9):462–467.
    • (2002) Trends Biochem Sci , vol.27 , Issue.9 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 35
    • 80755127903 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol 3-kinase pathway: Role in tumor progression and therapeutic implications in breast cancer
    • Miller TW, Rexer BN, Garrett JT, Arteaga CL. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res. 2011;13(6):224.
    • (2011) Breast Cancer Res , vol.13 , Issue.6
    • Miller, T.W.1    Rexer, B.N.2    Garrett, J.T.3    Arteaga, C.L.4
  • 36
    • 0032524104 scopus 로고    scopus 로고
    • Landscaping the cancer terrain
    • Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science. 1998;280(5366):1036–1037.
    • (1998) Science , vol.280 , Issue.5366 , pp. 1036-1037
    • Kinzler, K.W.1    Vogelstein, B.2
  • 37
    • 84873091765 scopus 로고    scopus 로고
    • The VHL/HIF axis in clear cell renal carcinoma
    • Shen C, Kaelin WG Jr. The VHL/HIF axis in clear cell renal carcinoma. Semin Cancer Biol. 2013;23(1):18–25.
    • (2013) Semin Cancer Biol , vol.23 , Issue.1 , pp. 18-25
    • Shen, C.1    Kaelin, W.G.2
  • 38
    • 41549107036 scopus 로고    scopus 로고
    • GATA-3 and the regulation of the mammary luminal cell fate
    • Kouros-Mehr H, Kim JW, Bechis SK, Werb Z. GATA-3 and the regulation of the mammary luminal cell fate. Curr Opin Cell Biol. 2008; 20(2):164–170.
    • (2008) Curr Opin Cell Biol , vol.20 , Issue.2 , pp. 164-170
    • Kouros-Mehr, H.1    Kim, J.W.2    Bechis, S.K.3    Werb, Z.4
  • 39
    • 84891061659 scopus 로고    scopus 로고
    • Wnt signaling in adult intestinal stem cells and cancer
    • Krausova M, Korinek V. Wnt signaling in adult intestinal stem cells and cancer. Cell Signal. 2014;26(3):570–579.
    • (2014) Cell Signal , vol.26 , Issue.3 , pp. 570-579
    • Krausova, M.1    Korinek, V.2
  • 40
    • 33751209189 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth
    • Schermer B, Ghenoiu C, Bartram M, et al. The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol. 2006;175(4):547–554.
    • (2006) J Cell Biol , vol.175 , Issue.4 , pp. 547-554
    • Schermer, B.1    Ghenoiu, C.2    Bartram, M.3
  • 41
    • 84905079134 scopus 로고    scopus 로고
    • The multifaceted von Hippel-Lindau tumour suppressor protein
    • Robinson CM, Ohh M. The multifaceted von Hippel-Lindau tumour suppressor protein. FEBS Lett. 2014;588(16):2704–2711.
    • (2014) FEBS Lett , vol.588 , Issue.16 , pp. 2704-2711
    • Robinson, C.M.1    Ohh, M.2
  • 42
    • 33751202983 scopus 로고    scopus 로고
    • GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    • Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 2006;127(5):1041–1055.
    • (2006) Cell , vol.127 , Issue.5 , pp. 1041-1055
    • Kouros-Mehr, H.1    Slorach, E.M.2    Sternlicht, M.D.3    Werb, Z.4
  • 43
    • 79956317112 scopus 로고    scopus 로고
    • Richard S. Von Hippel-Lindau disease: A clinical and scientific review
    • Maher ER, Neumann HP, Richard S. von Hippel-Lindau disease: a clinical and scientific review. Eur J Hum Genet. 2011;19(6): 617–623.
    • (2011) Eur J Hum Genet , vol.19 , Issue.6 , pp. 617-623
    • Maher, E.R.1    Neumann, H.P.2
  • 45
    • 84887536558 scopus 로고    scopus 로고
    • Somatic characterization of pediatric acute myeloid leukemia using next-generation sequencing
    • Schuback HL, Arceci RJ, Meshinchi S. Somatic characterization of pediatric acute myeloid leukemia using next-generation sequencing. Semin Hematol. 2013;50(4):325–332.
    • (2013) Semin Hematol , vol.50 , Issue.4 , pp. 325-332
    • Schuback, H.L.1    Arceci, R.J.2    Meshinchi, S.3
  • 46
    • 84555207349 scopus 로고    scopus 로고
    • Dnmt3a is essential for hematopoietic stem cell differentiation
    • Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2012;44(1):23–31.
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 23-31
    • Challen, G.A.1    Sun, D.2    Jeong, M.3
  • 47
    • 18844397298 scopus 로고    scopus 로고
    • De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine
    • Oka M, Meacham AM, Hamazaki T, Rodic N, Chang LJ, Terada N. De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine. Oncogene. 2005;24(19):3091–3099.
    • (2005) Oncogene , vol.24 , Issue.19 , pp. 3091-3099
    • Oka, M.1    Meacham, A.M.2    Hamazaki, T.3    Rodic, N.4    Chang, L.J.5    Terada, N.6
  • 48
    • 84908279899 scopus 로고    scopus 로고
    • DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: Associations with prognosis and potential treatment strategies
    • Im AP, Sehgal AR, Carroll MP, et al. DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia. 2014;28(9):1774–1783.
    • (2014) Leukemia , vol.28 , Issue.9 , pp. 1774-1783
    • Im, A.P.1    Sehgal, A.R.2    Carroll, M.P.3
  • 49
  • 50
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424–2433.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 51
    • 77950475617 scopus 로고    scopus 로고
    • Mixed lineage leukemia: Roles in gene expression, hormone signaling and mRNA processing
    • Ansari KI, Mandal SS. Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. FEBS J. 2010;277(8):1790–1804.
    • (2010) FEBS J , vol.277 , Issue.8 , pp. 1790-1804
    • Ansari, K.I.1    Mandal, S.S.2
  • 52
    • 84856916060 scopus 로고    scopus 로고
    • The pathogenesis of mixed-lineage leukemia
    • Muntean AG, Hess JL. The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol. 2012;7:283–301.
    • (2012) Annu Rev Pathol , vol.7 , pp. 283-301
    • Muntean, A.G.1    Hess, J.L.2
  • 53
    • 79959653996 scopus 로고    scopus 로고
    • SWI/SNF nucleosome remodellers and cancer
    • Wilson BG, Roberts CW. SWI/SNF nucleosome remodellers and cancer. Nat Rev Cancer. 2011;11(7):481–492.
    • (2011) Nat Rev Cancer , vol.11 , Issue.7 , pp. 481-492
    • Wilson, B.G.1    Roberts, C.W.2
  • 54
    • 84872868948 scopus 로고    scopus 로고
    • ARID1A mutations in cancer: Another epigenetic tumor suppressor?
    • Wu JN, Roberts CW. ARID1A mutations in cancer: another epigenetic tumor suppressor? Cancer Discov. 2013;3(1):35–43.
    • (2013) Cancer Discov , vol.3 , Issue.1 , pp. 35-43
    • Wu, J.N.1    Roberts, C.W.2
  • 55
    • 80155131218 scopus 로고    scopus 로고
    • ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers
    • Guan B, Wang TL, Shih IeM. ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer Res. 2011;71(21):6718–6727.
    • (2011) Cancer Res , vol.71 , Issue.21 , pp. 6718-6727
    • Guan, B.1    Wang, T.L.2    Shih, I.E.3
  • 56
    • 84860327480 scopus 로고    scopus 로고
    • Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
    • Zang ZJ, Cutcutache I, Poon SL, et al. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet. 2012;44(5): 570–574.
    • (2012) Nat Genet , vol.44 , Issue.5 , pp. 570-574
    • Zang, Z.J.1    Cutcutache, I.2    Poon, S.L.3
  • 57
    • 44349105786 scopus 로고    scopus 로고
    • ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
    • Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008;105(18): 6656–6661.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.18 , pp. 6656-6661
    • Gao, X.1    Tate, P.2    Hu, P.3    Tjian, R.4    Skarnes, W.C.5    Wang, Z.6
  • 58
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2(2):117–125.
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 59
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2(3):e73.
    • (2005) Plos Med , vol.2 , Issue.3
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 60
    • 84894592208 scopus 로고    scopus 로고
    • Ever-advancing chronic myeloid leukemia treatment
    • Kimura S, Ando T, Kojima K. Ever-advancing chronic myeloid leukemia treatment. Int J Clin Oncol. 2014;19(1):3–9.
    • (2014) Int J Clin Oncol , vol.19 , Issue.1 , pp. 3-9
    • Kimura, S.1    O, T.2    Kojima, K.3
  • 61
    • 84905366894 scopus 로고    scopus 로고
    • Acquired resistance to TKIs in solid tumours: Learning from lung cancer
    • Camidge DR, Pao W, Sequist LV. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat Rev Clin Oncol. 2014;11(8):473–481.
    • (2014) Nat Rev Clin Oncol , vol.11 , Issue.8 , pp. 473-481
    • Camidge, D.R.1    Pao, W.2    Sequist, L.V.3
  • 62
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • EBCTCG. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365(9472):1687–1717.
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 63
    • 42949112558 scopus 로고    scopus 로고
    • Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen
    • Goss PE, Ingle JN, Pater JL, et al. Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen. J Clin Oncol. 2008;26(12): 1948–1955.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 1948-1955
    • Goss, P.E.1    Ingle, J.N.2    Pater, J.L.3
  • 64
    • 79953311521 scopus 로고    scopus 로고
    • A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance
    • Miller TW, Balko JM, Ghazoui Z, et al. A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance. Clin Cancer Res. 2011;17(7):2024–2034.
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 2024-2034
    • Miller, T.W.1    Balko, J.M.2    Ghazoui, Z.3
  • 65
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne CK, Schiff R. Mechanisms of endocrine resistance in breast cancer. Annu Rev Med. 2011;62:233–247.
    • (2011) Annu Rev Med , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 66
    • 80155131176 scopus 로고    scopus 로고
    • A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer
    • Fox EM, Miller TW, Balko JM, et al. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res. 2011;71(21):6773–6784.
    • (2011) Cancer Res , vol.71 , Issue.21 , pp. 6773-6784
    • Fox, E.M.1    Miller, T.W.2    Balko, J.M.3
  • 67
    • 81755162797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
    • Miller TW, Balko JM, Arteaga CL. Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. J Clin Oncol. 2011;29(33): 4452–4461.
    • (2011) J Clin Oncol , vol.29 , Issue.33 , pp. 4452-4461
    • Miller, T.W.1    Balko, J.M.2    Arteaga, C.L.3
  • 68
    • 49649127657 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Engelman JA, Janne PA. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res. 2008;14(10):2895–2899.
    • (2008) Clin Cancer Res , vol.14 , Issue.10 , pp. 2895-2899
    • Engelman, J.A.1    Janne, P.A.2
  • 69
    • 84864286442 scopus 로고    scopus 로고
    • Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
    • Wilson TR, Fridlyand J, Yan Y, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487(7408):505–509.
    • (2012) Nature , vol.487 , Issue.7408 , pp. 505-509
    • Wilson, T.R.1    Fridlyand, J.2    Yan, Y.3
  • 70
    • 84858005733 scopus 로고    scopus 로고
    • Acquired resistance to drugs targeting receptor tyrosine kinases
    • Rosenzweig SA. Acquired resistance to drugs targeting receptor tyrosine kinases. Biochem Pharmacol. 2012;83(8):1041–1048.
    • (2012) Biochem Pharmacol , vol.83 , Issue.8 , pp. 1041-1048
    • Rosenzweig, S.A.1
  • 71
    • 84888381937 scopus 로고    scopus 로고
    • Activating ESR1 mutations in hormone-resistant metastatic breast cancer
    • Robinson DR, Wu YM, Vats P, et al. Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet. 2013;45(12): 1446–1451.
    • (2013) Nat Genet , vol.45 , Issue.12 , pp. 1446-1451
    • Robinson, D.R.1    Wu, Y.M.2    Vats, P.3
  • 72
    • 84888391516 scopus 로고    scopus 로고
    • ESR1 ligand-binding domain mutations in hormone-resistant breast cancer
    • Toy W, Shen Y, Won H, et al. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet. 2013;45(12): 1439–1445.
    • (2013) Nat Genet , vol.45 , Issue.12 , pp. 1439-1445
    • Toy, W.1    Shen, Y.2    Won, H.3
  • 73
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353(16):1673–1684.
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 74
    • 26844503270 scopus 로고    scopus 로고
    • Herceptin Adjuvant (HERA) Trial Study Team. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al; Herceptin Adjuvant (HERA) Trial Study Team. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353(16): 1659–1672.
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 75
    • 84880525684 scopus 로고    scopus 로고
    • A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop
    • Ware KE, Hinz TK, Kleczko E, et al. A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop. Oncogenesis. 2013;2:e39.
    • (2013) Oncogenesis , vol.2
    • Ware, K.E.1    Hinz, T.K.2    Kleczko, E.3
  • 77
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature. 2012;483(7387):100–103.
    • (2012) Nature , vol.483 , Issue.7387 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3
  • 78
    • 33845444046 scopus 로고    scopus 로고
    • IRIS Investigators. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O’Brien SG, et al; IRIS Investigators. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355(23):2408–2417.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O’Brien, S.G.3
  • 79
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet. 2007;8(5):341–352.
    • (2007) Nat Rev Genet , vol.8 , Issue.5 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 80
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009;9(4):274–284.
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 81
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147(2):275–292.
    • (2011) Cell , vol.147 , Issue.2 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 82
    • 84885352426 scopus 로고    scopus 로고
    • Origins of metastatic traits
    • Vanharanta S, Massague J. Origins of metastatic traits. Cancer Cell. 2013;24(4):410–421.
    • (2013) Cancer Cell , vol.24 , Issue.4 , pp. 410-421
    • Vanharanta, S.1    Massague, J.2
  • 83
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 2000;406(6795): 532–535.
    • (2000) Nature , vol.406 , Issue.6795 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 84
    • 84907494105 scopus 로고    scopus 로고
    • Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame
    • Gentry LR, Martin TD, Reiner DJ, Der CJ. Ral small GTPase signaling and oncogenesis: more than just 15minutes of fame. Biochim Biophys Acta. 2014;1843(12):2976–2988.
    • (2014) Biochim Biophys Acta , vol.1843 , Issue.12 , pp. 2976-2988
    • Gentry, L.R.1    Martin, T.D.2    Reiner, D.J.3    Der, C.J.4
  • 85
    • 33646576169 scopus 로고    scopus 로고
    • Matrix met alloproteinases and tumor metastasis
    • Deryugina EI, Quigley JP. Matrix met alloproteinases and tumor metastasis. Cancer Metastasis Rev. 2006;25(1):9–34.
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.1 , pp. 9-34
    • Deryugina, E.I.1    Quigley, J.P.2
  • 87
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 2004;117(7):927–939.
    • (2004) Cell , vol.117 , Issue.7 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 88
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang Y, Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell. 2004;118(3):277–279.
    • (2004) Cell , vol.118 , Issue.3 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 89
    • 80054725681 scopus 로고    scopus 로고
    • Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
    • Chen Q, Zhang XH, Massague J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell. 2011;20(4):538–549.
    • (2011) Cancer Cell , vol.20 , Issue.4 , pp. 538-549
    • Chen, Q.1    Zhang, X.H.2    Massague, J.3
  • 90
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos PD, Zhang XH, Nadal C, et al. Genes that mediate breast cancer metastasis to the brain. Nature. 2009;459(7249):1005–1009.
    • (2009) Nature , vol.459 , Issue.7249 , pp. 1005-1009
    • Bos, P.D.1    Zhang, X.H.2    Nadal, C.3
  • 91
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006;124(2):263–266.
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 92
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: A magic bullet?
    • Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science. 2013;339(6117): 286–291.
    • (2013) Science , vol.339 , Issue.6117 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 93
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • Tan W, Zhang W, Strasner A, et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011;470(7335):548–553.
    • (2011) Nature , vol.470 , Issue.7335 , pp. 548-553
    • Tan, W.1    Zhang, W.2    Strasner, A.3
  • 94
    • 84863756518 scopus 로고    scopus 로고
    • Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
    • Wolf MJ, Hoos A, Bauer J, et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell. 2012;22(1):91–105.
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 91-105
    • Wolf, M.J.1    Hoos, A.2    Bauer, J.3
  • 95
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–899.
    • (2010) Cell , vol.140 , Issue.6 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 96
    • 41949139438 scopus 로고    scopus 로고
    • Comparative lesion sequencing provides insights into tumor evolution
    • Jones S, Chen WD, Parmigiani G, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A. 2008;105(11):4283–4288.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.11 , pp. 4283-4288
    • Jones, S.1    Chen, W.D.2    Parmigiani, G.3
  • 97
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell PJ, Yachida S, Mudie LJ, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010;467(7319):1109–1113.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1109-1113
    • Campbell, P.J.1    Yachida, S.2    Mudie, L.J.3
  • 98
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010;467(7319): 1114–1117.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 99
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van ‘t Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415(6871): 530–536.
    • (2002) Nature , vol.415 , Issue.6871 , pp. 530-536
    • Van ‘t Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3
  • 100
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van’t Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 2002;347(25):1999–2009.
    • (2002) N Engl J Med , vol.347 , Issue.25 , pp. 1999-2009
    • Van De Vijver, M.J.1    He, Y.D.2    Van’T Veer, L.J.3
  • 101
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nat Genet. 2003;33(1):49–54.
    • (2003) Nat Genet , vol.33 , Issue.1 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 102
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883–892.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 103
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah SP, Morin RD, Khattra J, et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009;461(7265):809–813.
    • (2009) Nature , vol.461 , Issue.7265 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3
  • 104
    • 79551693066 scopus 로고    scopus 로고
    • Circulating tumor cells: Approaches to isolation and characterization
    • Yu M, Stott S, Toner M, Maheswaran S, Haber DA. Circulating tumor cells: approaches to isolation and characterization. J Cell Biol. 2011;192(3):373–382.
    • (2011) J Cell Biol , vol.192 , Issue.3 , pp. 373-382
    • Yu, M.1    Stott, S.2    Toner, M.3    Maheswaran, S.4    Haber, D.A.5
  • 105
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004;351(8):781–791.
    • (2004) N Engl J Med , vol.351 , Issue.8 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 106
    • 84863105627 scopus 로고    scopus 로고
    • Circulating tumour cells in non-metastatic breast cancer: A prospective study
    • Lucci A, Hall CS, Lodhi AK, et al. Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncol. 2012;13(7):688–695.
    • (2012) Lancet Oncol , vol.13 , Issue.7 , pp. 688-695
    • Lucci, A.1    Hall, C.S.2    Lodhi, A.K.3
  • 107
    • 84885361305 scopus 로고    scopus 로고
    • Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients
    • Fischer JC, Niederacher D, Topp SA, et al. Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients. Proc Natl Acad Sci U S A. 2013;110(41): 16580–16585.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.41 , pp. 16580-16585
    • Fischer, J.C.1    Niederacher, D.2    Topp, S.A.3
  • 108
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • Nagrath S, Sequist LV, Maheswaran S, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature. 2007;450(7173):1235–1239.
    • (2007) Nature , vol.450 , Issue.7173 , pp. 1235-1239
    • Nagrath, S.1    Sequist, L.V.2    Maheswaran, S.3
  • 109
    • 77953015030 scopus 로고    scopus 로고
    • Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer
    • 25ra23
    • Stott SL, Lee RJ, Nagrath S, et al. Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med. 2010;2(25):25ra23.
    • (2010) Sci Transl Med , vol.2 , Issue.25
    • Stott, S.L.1    Lee, R.J.2    Nagrath, S.3
  • 110
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Husemann Y, Geigl JB, Schubert F, et al. Systemic spread is an early step in breast cancer. Cancer Cell. 2008;13(1):58–68.
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 58-68
    • Husemann, Y.1    Geigl, J.B.2    Schubert, F.3
  • 111
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim AD, Mirek ET, Aiello NM, et al. EMT and dissemination precede pancreatic tumor formation. Cell. 2012;148(1–2):349–361.
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3
  • 112
    • 24944534497 scopus 로고    scopus 로고
    • Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer
    • Schardt JA, Meyer M, Hartmann CH, et al. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell. 2005;8(3):227–239.
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 227-239
    • Schardt, J.A.1    Meyer, M.2    Hartmann, C.H.3
  • 113
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139(5):871–890.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 114
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348(6230):56–61.
    • (2015) Science , vol.348 , Issue.6230 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.