Antimicrobial activity of human α-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs

Peptides

Volumn 71, Issue , 2015, Pages 128-140

  Mathew, Basil ^a   Nagaraj, Ramakrishnan ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Antimicrobial activity; Defensin analogs; DNA binding; Fatty acylation; Synthetic peptides

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 5; ANTIINFECTIVE AGENT; CYSTEINE; PLASMID DNA; UNCLASSIFIED DRUG; ALPHA-DEFENSIN 5, HUMAN;

ACYLATION; AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL MEMBRANE; BACTERIAL METABOLISM; BINDING AFFINITY; CANDIDA ALBICANS; CELL DEATH; CYTOPLASM; DRUG DNA BINDING; DRUG MECHANISM; ESCHERICHIA COLI; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM FUNGICIDAL CONCENTRATION; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA; SACCHAROMYCES CEREVISIAE; SMALL INTESTINE; STAPHYLOCOCCUS AUREUS; SURFACE PROPERTY; CHEMISTRY; GROWTH, DEVELOPMENT AND AGING; PROTEIN SECONDARY STRUCTURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ACYLATION; ALPHA-DEFENSINS; ANTI-INFECTIVE AGENTS; ESCHERICHIA COLI; HUMANS; PROTEIN STRUCTURE, SECONDARY;

EID: 84938054670     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2015.07.009     Document Type: Article

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