Design of a Potent Antibiotic Peptide Based on the Active Region of Human Defensin 5

Journal of Medicinal Chemistry

Volumn 58, Issue 7, 2015, Pages 3083-3093

  Wang, Cheng ^a   Shen, Mingqiang ^a   Gohain, Neelakshi ^b   Tolbert, William D ^b   Chen, Fang ^a   Zhang, Naixin ^a   Yang, Ke ^a   Wang, Aiping ^a   Su, Yongping ^a   Cheng, Tianmin ^a   Zhao, Jinghong ^a   Pazgier, Marzena ^b   Wang, Junping ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; DEFENSIN 5; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ALPHA DEFENSIN; ALPHA-DEFENSIN 5, HUMAN; ANTIINFECTIVE AGENT; ARGININE; PEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; BINDING KINETICS; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; INNER MEMBRANE; ISOTHERMAL TITRATION CALORIMETRY; MUTAGENESIS; NONHUMAN; OUTER MEMBRANE; STAPHYLOCOCCUS AUREUS; STATIC ELECTRICITY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; ERYTHROCYTE; GENETICS; METABOLISM; MOUSE; PROCEDURES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALPHA-DEFENSINS; ANIMALS; ANTI-BACTERIAL AGENTS; ARGININE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; ESCHERICHIA COLI; MICE; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84927598991     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501824a     Document Type: Article

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