Endogenous animal toxin-like human β-defensin 2 inhibits own K+ channels through interaction with channel extracellular pore region

Cellular and Molecular Life Sciences

Volumn 72, Issue 4, 2015, Pages 845-853

  Yang, Weishan ^a   Feng, Jing ^a   Xiang, Fang ^a   Xie, Zili ^a   Zhang, Guoyi ^b   Sabatier, Jean Marc ^c   Cao, Zhijian ^a   Li, Wenxin ^a   Chen, Zongyun ^a   Wu, Yingliang ^a  

^a WUHAN UNIVERSITY   (China)

^b Institute of Sexually Transmitted Diseases Chinese Academy of Medicines   (China)

^c AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Adaptive immune modulation; Antibacterial and antiviral peptide; Cytokine secretion; Endogenous inhibitors; Interaction mechanism; Lymphocyte

Indexed keywords

BETA DEFENSIN 2; INTERLEUKIN 2; POTASSIUM CHANNEL KV1.3; TOXIN; BETA DEFENSIN; DEFB4A PROTEIN, HUMAN; PROTEIN BINDING; SMALL INTERFERING RNA;

ARTICLE; BINDING SITE; CD3+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BINDING; PROTEIN DOMAIN; PSORIASIS; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; GENETICS; JURKAT CELL LINE; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; MUTAGENESIS; PATCH CLAMP TECHNIQUE; RNA INTERFERENCE; SEQUENCE ALIGNMENT; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; BETA-DEFENSINS; BINDING SITES; CELLS, CULTURED; HUMANS; INTERLEUKIN-2; JURKAT CELLS; KV1.3 POTASSIUM CHANNEL; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RNA INTERFERENCE; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; T-LYMPHOCYTES; TOXINS, BIOLOGICAL;

EID: 84925487807     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1715-z     Document Type: Article

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