Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-Aryl-substituted 2-bis-1H-benzimidazoles

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 659-669

  Singh, Manish ^a,b   Tandon, Vibha ^a  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Antitumor activity; Bisbenzimidazole; Calf Thymus DNA; Hoechst 33342; MTT; Topoisomerase I

Indexed keywords

2 (2,4 DICHLOROPHENYL) 5 [5 (4 METHYLPIPERAZIN 1 YL) 1H BENZIMIDAZOL 2 YL] 1H BENZIMIDAZOLE; 2 (2,4 DIFLUOROPHENYL) 5 [5 (4 METHYLPIPERAZIN 1 YL) 1H BENZIMIDAZOL 2 YL] 1H BENZIMIDAZOLE; 2 (3,4 DIMETHOXYPHENYL) 5 [5 (4 METHYLPIPERAZIN 1 YL) 1H BENZIMIDAZOL 2 YL] 1H BENZIMIDAZOLE; 2 (3,4,5 TRIMETHOXYPHENYL) 5 [5 (4 METHYLPIPERAZIN 1 YL) 1H BENZIMIDAZOL 2 YL] 1H BENZIMIDAZOLE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CATTLE; CELL PROLIFERATION; DNA; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 79151486288     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.046     Document Type: Article

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