Discovery of Novel 2-N-Aryl-Substituted Benzenesulfonamidoacetamides: Orally Bioavailable Tubulin Polymerization Inhibitors with Marked Antitumor Activities

ChemMedChem

Volumn 7, Issue 4, 2012, Pages 680-693

  Liu, Zulong ^a   Zhou, Zuyu ^a   Tian, Wei ^b   Fan, Xing ^a   Xue, Ding ^a   Yu, Long ^c   Yu, Qiang ^a   Long, Ya Qiu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Antitumor agents; Benzenesulfonamidoacetamides; Bioactive compounds; Screening; Tubulin

Indexed keywords

2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO] N (4 PHENOXYPHENYL)ACETAMIDE; 2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO] N (PYRIDIN 2 YL)ACETAMIDE; 2 [4 METHYL N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO] N (1H 1,2,4 TRIAZOL 3 YL)ACETAMIDE; 2 [4 METHYL N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO] N (PYRIDIN 3 YL)ACETAMIDE; 2 [4 METHYL N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO]ACETAMIDE; 2 [N (4 METHOXYPHENYL) 4 METHYLPHENYLSULFONAMIDO] N (PYRIDIN 2 YL)ACETAMIDE; 2 [N [3 (TRIFLUOROMETHYL)PHENYL]METHYLSULFONAMIDO]ACETAMIDE; AH 487; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; GLYCOPROTEIN P; N (1H 1,2,4 TRIAZOL 3 YL) 2 [N [3 (TRIFLUOROMETHYL)PHENYL]METHYLSULFONAMIDO]ACETAMIDE; N (1H INDOL 5 YL) 2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO]ACETAMIDE; N (1H INDOL 5 YL) 2 [4 METHYL N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO]ACETAMIDE; N (1H INDOL 5 YL) 2 [N [3 (TRIFLUOROMETHYL)PHENYL]METHYLSULFONAMIDO]ACETAMIDE; N (2 AMINOPHENYL) 2 [4 METHOXY N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO]ACETAMIDE; N (2 AMINOPHENYL) 2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO]ACETAMIDE; N (2 AMINOPHENYL) 2 [4 METHYL N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO]ACETAMIDE; N (2 AMINOPHENYL) 2 [N [3 (TRIFLUOROMETHYL)PHENYL]METHYLSULFONAMIDO]ACETAMIDE; N (4 AMINOPHENYL) 2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO]ACETAMIDE; N (4 AMINOPHENYL) 2 [4 METHYL N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO]ACETAMIDE; N (4 AMINOPHENYL) 2 [N [3 (TRIFLUOROMETHYL)PHENYL]METHYLSULFONAMIDO]ACETAMIDE; N (4 FLUOROBENZYL) 2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO]ACETAMIDE; N (4 METHOXYPHENYL) 2 [4 METHYL N (3 NITROPHENYL)PHENYLSULFONAMIDO]ACETAMIDE; N (4 METHOXYPHENYL) 4 METHYLBENZENESULFONAMIDE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; N HETEROARYL 2 [4 METHOXY N [3 (TRIFLUOROMETHYL)PHENYL]PHENYLSULFONAMIDO]ACETAMIDE; PROTEIN BCL 2; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; M PHASE CELL CYCLE CHECKPOINT; MALE; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SUBSTITUTION REACTION; THERAPY EFFECT;

AMINOPHENOLS; ANIMALS; ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL AVAILABILITY; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; G2 PHASE; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICROTUBULES; MOLECULAR STRUCTURE; P-GLYCOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFONAMIDES; TUBULIN MODULATORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859175813     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100529     Document Type: Article

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