Resistance-modifying agents. 5.1 Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)

Journal of Medicinal Chemistry

Volumn 41, Issue 26, 1998, Pages 5247-5256

  Griffin, Roger J ^a   Srinivasan, Sheila ^a   Bowman, Karen ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (3 METHYLTRIAZEN 1YL)IMIDAZOLE 4 CARBOXAMIDE; 8 HYDROXYQUINAZOLINONE DERIVATIVE; 8 METHOXY 2 METHYLQUINAZOLINONE DERIVATIVE; 8 METHOXYQUINAZOLINEONE DERIVATIVE; 8 METHYLQUINAZOLINEONE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CYTOTOXICITY; DNA DAMAGE; DRUG STRUCTURE; DRUG SYNTHESIS; GAMMA RADIATION; HYDROGENATION; STRUCTURE ACTIVITY RELATION;

ALKYLATING AGENTS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DACARBAZINE; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME INHIBITORS; GAMMA RAYS; LEUKEMIA L1210; MICE; POLY(ADP-RIBOSE) POLYMERASES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0032542252     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980273t     Document Type: Article

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