Applications of polymer micelles for imaging and drug delivery

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 7, Issue 5, 2015, Pages 691-707

  Movassaghian, Sara ^a,b   Merkel, Olivia M ^a,b   Torchilin, Vladimir P ^c  

^a WAYNE STATE UNIVERSITY   (United States)

^b KARMANOS CANCER INSTITUTE   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; BLOCK COPOLYMERS; COPOLYMERS; DRUG DELIVERY; GENE TRANSFER; POLYMERS;

AMPHIPHILIC CO-POLYMERS; DIAGNOSTIC IMAGING; ENHANCED PERMEABILITY AND RETENTION EFFECT; INTRACELLULAR ACCUMULATION; PHARMACEUTICAL AGENTS; POORLY SOLUBLE DRUGS; TARGETING LIGANDS; TRIGGERED DRUG RELEASE;

MICELLES;

APTAMER; CARBOHYDRATE; FOLIC ACID; LIGAND; MONOCLONAL ANTIBODY; NANOCARRIER; POLYMER; SOLUBILIZER; MICELLE;

ARTICLE; CHEMICAL STRUCTURE; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RETENTION; DRUG TARGETING; MICELLE; MICELLIZATION; MOLECULAR IMAGING; PH; PHARMACEUTICS; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN TARGETING; SUSTAINED DRUG RELEASE; THERMO SENSITIVE MICELLE; ANIMAL; CHEMISTRY; HUMAN; NEOPLASM; PATHOLOGY; PERMEABILITY;

ANIMALS; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEMS; HUMANS; MICELLES; NEOPLASMS; PERMEABILITY; POLYMERS;

EID: 84937817552     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1332     Document Type: Article

References (108)

1. Kazunori K, Glenn SK, Masayuki Y, Teruo O, Yasuhisa S. Block copolymer micelles as vehicles for drug delivery. J Control Release 1993, 24:119-132.
2. Cho H, Cho CS, Indig GL, Lavasanifar A, Vakili MR, Kwon GS. Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. PLoS One 2014, 9:e89968.
3. Gaucher G, Satturwar P, Jones M-C, Furtos A, Leroux J-C. Polymeric micelles for oral drug delivery. Eur J Pharm Biopharm 2010, 76:147-158.
4. Luschmann C, Tessmar J, Schoeberl S, Strauss O, Luschmann K, Goepferich A. Self-assembling colloidal system for the ocular administration of cyclosporine A. Cornea 2014, 33:77-81.
5. Kanazawa T, Morisaki K, Suzuki S, Takashima Y. Prolongation of life in rats with malignant glioma by intranasal siRNA/drug codelivery to the brain with cell-penetrating peptide-modified micelles. Mol Pharm 2014, 11:1471-1478.
6. Richter A, Olbrich C, Krause M, Hoffmann J, Kissel T. Polymeric micelles for parenteral delivery of sagopilone: physicochemical characterization, novel formulation approaches and their toxicity assessment in vitro as well as in vivo. Eur J Pharm Biopharm 2010, 75:80-89.
7. Torchilin VP. Structure and design of polymeric surfactant-based drug delivery systems. J Control Release 2001, 73:137-172.
8. Kwon GS, Okano T. Polymeric micelles as new drug carriers. Adv Drug Deliv Rev 1996, 21:107-116.
9. Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev 2013, 65:71-79.
10. Movassaghian S, Torchilin VP. Long circulating therapies for cancer treatment. In: Salnikova M, Singh M, eds. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. Academic Press, Elsevier; 2015, 443-470.
11. Fang J, Nakamura H, Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev 2011, 63:136-151.
12. Yokoyama M. Clinical applications of polymeric micelle carrier systems in chemotherapy and image diagnosis of solid tumors. J Exp Clin Med 2011, 3:151-158.
13. Matsumura Y, Kataoka K. Preclinical and clinical studies of anticancer agent-incorporating polymer micelles. Cancer Sci. 2009, 100:572-579.
14. Yokoyama M. Polymeric micelles as a new drug carrier system and their required considerations for clinical trials. Expert Opin Drug Deliv 2010, 7:145-158.
15. Lukyanov AN, Torchilin VP. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 2004, 56:1273-1289.
16. Paira TK, Saha A, Banerjee S, Das T, Das P, Jana NR, Mandal TK. Fluorescent amphiphilic PEG-peptide-PEG triblock conjugate micelles for cell imaging. Macromol Biosci 2014, 14:929-935.
17. Gracia CA, Gomez-Barreiro S, Gonzalez-Perez A, Nimo J, Rodriguez JR. Static and dynamic light-scattering studies on micellar solutions of alkyldimethylbenzylammonium chlorides. J Colloid Interface Sci 2004, 276:408-413.
18. Chaibundit C, Ricardo NMPS, Crothers M, Booth C. Micellization of diblock(oxyethylene/oxybutylene) copolymer E11B8 in aqueous solution. Micelle size and shape. Drug solubilization. Langmuir 2002, 18:4277-4283.
19. Herle V, Manneville S, Fischer P. Ultrasound velocimetry in a shear-thickening wormlike micellar solution: evidence for the coexistence of radial and vorticity shear bands. Eur Phys J E Soft Matter 2008, 26:3-12.
20. Yang L, Zhao Z, Wei J, El Ghzaoui A, Li S. Micelles formed by self-assembling of polylactide/poly(ethylene glycol) block copolymers in aqueous solutions. J Colloid Interface Sci 2007, 314:470-477.
21. Vakil R, Kwon GS. Poly(ethylene glycol)-b-poly(epsilon-caprolactone) and PEG-phospholipid form stable mixed micelles in aqueous media. Langmuir 2006, 22:9723-9729.
22. Cao J, Lu A, Li C, Cai M, Chen Y, Li S, Luo X. Effect of architecture on the micellar properties of poly (varepsilon-caprolactone) containing sulfobetaines. Colloids Surf B Biointerfaces 2013, 112:35-41.
23. Colafemmina G, Fiorentino D, Ceglie A, Carretti E, Fratini E, Dei L, Baglioni P, Palazzo G. Structure of SDS micelles with propylene carbonate as cosolvent: a PGSE-NMR and SAXS study. J Phys Chem B 2007, 111:7184-7193.
24. Patterson JP, Kelley EG, Murphy RP, Moughton AO, Robin M, Lu A, Colombani O, Chassenieux C, Cheung D, Sullivan MO, et al. Structural characterization of amphiphilic homopolymer micelles using light scattering, SANS, and cryo-TEM. Macromolecules 2013, 46:6319-6325.
25. Byrappa K, Ohara S, Adschiri T. Nanoparticles synthesis using supercritical fluid technology-towards biomedical applications. Adv Drug Deliv Rev 2008, 60:299-327.
26. Liu J, Yang S, Lee CS, DeVoe DL. Polyacrylamide gel plugs enabling 2-D microfluidic protein separations via isoelectric focusing and multiplexed sodium dodecyl sulfate gel electrophoresis. Electrophoresis 2008, 29:2241-2250.
27. Zhou J, Yuan X, Jiang M, Zhang Y. A novel fluorescence probe for micellization of amphiphilic molecules in water based on intramolecular exciplex formation. Macromol Rapid Commun 2000, 21:579-582.
28. Chattopadhyay A, London E. Fluorimetric determination of critical micelle concentration avoiding interference from detergent charge. Anal Biochem 1984, 139:408-412.
29. Bahadur P, Sastry NV, Rao YK, Riess G. Interaction studies of styrene-ethylene oxide block copolymers with ionic surfactants in aqueous solution. Colloids Surf 1988, 29:343-358.
30. Liu J, Zeng F, Allen C. Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent. J Control Release 2005, 103:481-497.
31. Shabbits JA, Chiu GN, Mayer LD. Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems. J Control Release 2002, 84:161-170.
32. Szebeni J, Urbanics R. Complement activation-related pseudoallergy caused by nanomedicines and its testing in vitro and in vivo. In: Logothetidis S, ed. Nanomedicine and Nanobiotechnology. Springer Berlin/Heidelberg; 2012, 109-114.
33. Owen SC, Chan DPY, Shoichet MS. Polymeric micelle stability. Nano Today 2012, 7:53-65.
34. Ren T-B, Xia W-J, Dong H-Q, Li Y-Y. Sheddable micelles based on disulfide-linked hybrid PEG-polypeptide copolymer for intracellular drug delivery. Polymer 2011, 52:3580-3586.
35. Kataoka K, Matsumoto T, Yokoyama M, Okano T, Sakurai Y, Fukushima S, Okamoto K, Kwon GS. Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. J Control Release 2000, 64:143-153.
36. Avgoustakis K, Beletsi A, Panagi Z, Klepetsanis P, Karydas AG, Ithakissios DS. PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties. J Control Release 2002, 79:123-135.
37. Shim WS, Kim SW, Choi E-K, Park H-J, Kim J-S, Lee DS. Novel pH sensitive block copolymer micelles for solvent free drug loading. Macromol Biosci 2006, 6:179-186.
38. Nakayama M, Okano T, Miyazaki T, Kohori F, Sakai K, Yokoyama M. Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. J Control Release 2006, 115:46-56.
39. Aliabadi HM, Elhasi S, Mahmud A, Gulamhusein R, Mahdipoor P, Lavasanifar A. Encapsulation of hydrophobic drugs in polymeric micelles through co-solvent evaporation: the effect of solvent composition on micellar properties and drug loading. Int J Pharm 2007, 329:158-165.
40. Fournier E, Dufresne M-H, Smith D, Ranger M, Leroux J-C. A novel one-step drug-loading procedure for water-soluble amphiphilic nanocarriers. Pharm Res 2004, 21:962-968.
41. Bae Y, Kataoka K. Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers. Adv Drug Deliv Rev 2009, 61:768-784.
42. Li G, Guo L, Meng Y, Zhang T. Self-assembled nanoparticles from thermo-sensitive polyion complex micelles for controlled drug release. Chem Eng J 2011, 174:199-205.
43. Kwon G, Suwa S, Yokoyama M, Okano T, Sakurai Y, Kataoka K. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates. J Control Release 1994, 29:17-23.
44. Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 2005, 22:11-23.
45. Xu W, Ling P, Zhang T. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. J Drug Deliv 2013, 340315:27.
46. Gelderblom H, Verweij J, Nooter K, Sparreboom A. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer 2001, 37:1590-1598.
47. Savic R, Eisenberg A, Maysinger D. Block copolymer micelles as delivery vehicles of hydrophobic drugs: micelle-cell interactions. J Drug Target 2006, 14:343-355.
48. Chiappetta DA, Hocht C, Taira C, Sosnik A. Oral pharmacokinetics of the anti-HIV efavirenz encapsulated within polymeric micelles. Biomaterials 2011, 32:2379-2387.
49. Gaucher G, Dufresne MH, Sant VP, Kang N, Maysinger D, Leroux JC. Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release 2005, 109:169-188.
50. Burt HM, Zhang X, Toleikis P, Embree L, Hunter WL. Development of copolymers of poly(d, l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Colloids Surf B Biointerfaces 1999, 16:161-171.
51. Kato K, Chin K, Yoshikawa T, Yamaguchi K, Tsuji Y, Esaki T, Sakai K, Kimura M, Hamaguchi T, Shimada Y, et al. Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer. Invest New Drugs 2012, 30:1621-1627.
52. Hamaguchi T, Kato K, Yasui H, Morizane C, Ikeda M, Ueno H, Muro K, Yamada Y, Okusaka T, Shirao K, et al. A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation. Br J Cancer 2007, 97:170-176.
53. Matsumura Y. Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect. Adv Drug Deliv Rev 2011, 63:184-192.
54. Takahashi A, Yamamoto Y, Yasunaga M, Koga Y, Kuroda J, Takigahira M, Harada M, Saito H, Hayashi T, Kato Y, et al. NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin. Cancer Sci 2013, 104:920-925.
55. Plummer R, Wilson RH, Calvert H, Boddy AV, Griffin M, Sludden J, Tilby MJ, Eatock M, Pearson DG, Ottley CJ, et al. A phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. Br J Cancer 2011, 104:593-598.
56. Cabral H, Murakami M, Hojo H, Terada Y, Kano MR, Chung UI, Nishiyama N, Kataoka K. Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc Natl Acad Sci USA 2013, 110:11397-11402.
57. Valle JW, Armstrong A, Newman C, Alakhov V, Pietrzynski G, Brewer J, Campbell S, Corrie P, Rowinsky EK, Ranson M. A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction. Invest New Drugs 2011, 29:1029-1037.
58. Lee J-L, Ahn J-H, Park S, Lim H, Kwon J, Ahn S, Song C, Hong J, Kim C-S, Ahn H. Phase II study of a cremophor-free, polymeric micelle formulation of paclitaxel for patients with advanced urothelial cancer previously treated with gemcitabine and platinum. Invest New Drugs 2012, 30:1984-1990.
59. Gill KK, Nazzal S, Kaddoumi A. Paclitaxel loaded PEG5000-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. Eur J Pharm Biopharm 2011, 79:276-284.
60. Hamaguchi T, Matsumura Y, Suzuki M, Shimizu K, Goda R, Nakamura I, Nakatomi I, Yokoyama M, Kataoka K, Kakizoe T. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer 2005, 92:1240-1246.
61. Bromberg L. Polymeric micelles in oral chemotherapy. J Control Release 2008, 128:99-112.
62. Zhu L, Movassaghian S, Torchilin VP. Chapter 8.1 overcoming biological barriers with parenteral nanomedicines: physiological and mechanistic issues. In: Nanostructured Biomaterials for Overcoming Biological Barriers. Cambridge, UK: The Royal Society of Chemistry; 2012, 435-455.
63. Guo P, Coban O, Snead NM, Trebley J, Hoeprich S, Guo S, Shu Y. Engineering RNA for targeted siRNA delivery and medical application. Adv Drug Deliv Rev 2010, 62:650-666.
64. Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 1995, 55:3752-3756.
65. Torchilin V. Tumor delivery of macromolecular drugs based on the EPR effect. Adv Drug Deliv Rev 2011, 63:131-135.
66. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA 1998, 95:4607-4612.
67. Weissig V, Whiteman KR, Torchilin VP. Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice. Pharm Res 1998, 15:1552-1556.
68. Hatakeyama H, Akita H, Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 2011, 63:152-160.
69. Craparo EF, Sardo C, Serio R, Zizzo MG, Bondi ML, Giammona G, Cavallaro G. Galactosylated polymeric carriers for liver targeting of sorafenib. Int J Pharm 2014, 466:172-180.
70. Sawant RR, Jhaveri AM, Torchilin VP. Immunomicelles for advancing personalized therapy. Adv Drug Deliv Rev 2012, 64:1436-1446.
71. Torchilin VP, Lukyanov AN, Gao Z, Papahadjopoulos-Sternberg B. Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs. Proc Natl Acad Sci USA 2003, 100:6039-6044.
72. Yang C, Chen H, Zhao J, Pang X, Xi Y, Zhai G. Development of a folate-modified curcumin loaded micelle delivery system for cancer targeting. Colloids Surf B Biointerfaces 2014, 121:206-213.
73. Danhier F, Le Breton A, Preat V. RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. Mol Pharm 2012, 9:2961-2973.
74. Jiang G, Wang Y, Zhang R, Wang R, Wang X, Zhang M, Sun X, Bao S, Wang T, Wang S. Preparation of redox-sensitive shell cross-linked nanoparticles for controlled release of bioactive agents. ACS Macro Lett 2012, 1:489-493.
75. Wang R, Hu X, Yue J, Zhang W, Cai L, Xie Z, Huang Y, Jing X. Luteinizing-hormone-releasing-hormone-containing biodegradable polymer micelles for enhanced intracellular drug delivery. J Mater Chem B 2013, 1:293-301.
76. Kim BY, Bae JW, Park KD. Enzymatically in situ shell cross-linked micelles composed of 4-arm PPO-PEO and heparin for controlled dual drug delivery. J Control Release 2013, 172:535-540.
77. Sawant RR, Jhaveri AM, Koshkaryev A, Zhu L, Qureshi F, Torchilin VP. Targeted transferrin-modified polymeric micelles: enhanced efficacy in vitro and in vivo in ovarian carcinoma. Mol Pharm 2014, 11:375-381.
78. Zhang P, Hu L, Yin Q, Zhang Z, Feng L, Li Y. Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: synthesis, preparation and in vivo evaluation. J Control Release 2012, 159:429-434.
79. Lu Y, Park K. Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs. Int J Pharm 2013, 453:198-214.
80. Wei H, Zhuo R-X, Zhang X-Z. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Prog Polym Sci 2013, 38:503-535.
81. Bae Y, Nishiyama N, Fukushima S, Koyama H, Yasuhiro M, Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 2005, 16:122-130.
82. Wu H, Zhu L, Torchilin VP. pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery. Biomaterials 2013, 34:1213-1222.
83. Sirsi SR, Borden MA. State-of-the-art materials for ultrasound-triggered drug delivery. Adv Drug Deliv Rev 2014, 72:3-14.
84. Brazel C. Magnetothermally-responsive nanomaterials: combining magnetic nanostructures and thermally-sensitive polymers for triggered drug release. Pharm Res 2009, 26:644-656.
85. Renno RZ, Miller JW. Photosensitizer delivery for photodynamic therapy of choroidal neovascularization. Adv Drug Deliv Rev 2001, 52:63-78.
86. Guo M, Mao H, Li Y, Zhu A, He H, Yang H, Wang Y, Tian X, Ge C, Peng Q, et al. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials 2014, 35:4656-4666.
87. Torchilin VP. Polymeric contrast agents for medical imaging. Curr Pharm Biotechnol 2000, 1:183-215.
88. Nishiyama N, Kataoka K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther 2006, 112:630-648.
89. Hu X, Jing X. Biodegradable amphiphilic polymer-drug conjugate micelles. Expert Opin Drug Deliv 2009, 6:1079-1090.
90. Yang H, Mao H, Wan Z, Zhu A, Guo M, Li Y, Li X, Wan J, Yang X, Shuai X, et al. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials 2013, 34:9124-9133.
91. Torchilin VP, Frank-Kamenetsky MD, Wolf GL. CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles. Acad Radiol 1999, 6:61-65.
92. Patil RR, Yu J, Banerjee SR, Ren Y, Leong D, Jiang X, Pomper M, Tsui B, Kraitchman DL, Mao HQ. Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging. Mol Ther 2011, 19:1626-1635.
93. Zhu L, Wang T, Perche F, Taigind A, Torchilin VP. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proc Natl Acad Sci USA 2013, 110:17047-17052.
94. Lee ES, Na K, Bae YH. Super pH-sensitive multifunctional polymeric micelle. Nano Lett 2005, 5:325-329.
95. Kim D, Lee ES, Oh KT, Gao ZG, Bae YH. Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Small 2008, 4:2043-2050.
96. Hoffman AS. The origins and evolution of "controlled" drug delivery systems. J Control Release 2008, 132:153-163.
97. Zhang Z, Grijpma DW, Feijen J. Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles. J Control Release 2006, 112:57-63.
98. Li X, Li H, Yi W, Chen J, Liang B. Acid-triggered core cross-linked nanomicelles for targeted drug delivery and magnetic resonance imaging in liver cancer cells. Int J Nanomedicine 2013, 8:3019-3031.
99. Xiao Y, Hong H, Javadi A, Engle JW, Xu W, Yang Y, Zhang Y, Barnhart TE, Cai W, Gong S. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging. Biomaterials 2012, 33:3071-3082.
100. Nasongkla N, Bey E, Ren J, Ai H, Khemtong C, Guthi JS, Chin SF, Sherry AD, Boothman DA, Gao J. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett 2006, 6:2427-2430.
101. Lee SY, Lee H, In I, Park SY. pH/redox/photo responsive polymeric micelle via boronate ester and disulfide bonds with spiropyran-based photochromic polymer for cell imaging and anticancer drug delivery. Eur Polym J 2014, 57:1-10.
102. Sawant RM, Hurley JP, Salmaso S, Kale A, Tolcheva E, Levchenko TS, Torchilin VP. "SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjug Chem 2006, 17:943-949.
103. Vatansever F, Chandran R, Sadasivam M, Chiang LY, Hamblin MR. Multi-functionality in theranostic nanoparticles: is more always better? J Nanomed Nanotechnol 2012, 3:120.
104. Fomina N, Sankaranarayanan J, Almutairi A. Photochemical mechanisms of light-triggered release from nanocarriers. Adv Drug Deliv Rev 2012, 64:1005-1020.
105. Gohy JF, Zhao Y. Photo-responsive block copolymer micelles: design and behavior. Chem Soc Rev 2013, 42:7117-7129.
106. Oerlemans C, Bult W, Bos M, Storm G, Nijsen JF, Hennink WE. Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res 2010, 27:2569-2589.
107. Rangel-Yagui CO, Pessoa A Jr, Tavares LC. Micellar solubilization of drugs. J Pharm Pharm Sci 2005, 8:147-165.
108. Riess G. Micellization of block copolymers. Prog Polym Sci 2003, 28:1107-1170.