Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems

Journal of Controlled Release

Volumn 84, Issue 3, 2002, Pages 161-170

  Shabbits, Jennifer A ^a,b   Chiu, Gigi N C ^a,b   Mayer, Lawrence D ^a,b,c  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c NONE   (Canada)

Author keywords

Drug release assay; Drug retention; Large unilamellar vesicles (LUV); Liposomes; Multilamellar vesicles (MLV)

Indexed keywords

DOXORUBICIN; LIPOSOME; SUCROSE; VERAPAMIL; DRUG CARRIER; MICROSPHERE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL; CENTRIFUGATION; CONTROLLED STUDY; DIALYSIS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG PELLET; DRUG RELEASE; DRUG RETENTION; ENCAPSULATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; TEMPERATURE; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; MATERIALS TESTING; METHODOLOGY; PARTICLE SIZE; PREDICTION AND FORECASTING; TISSUE DISTRIBUTION;

ANIMALS; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG CARRIERS; FEMALE; INJECTIONS, INTRAVENOUS; KINETICS; LIPOSOMES; MATERIALS TESTING; MICE; MICROSPHERES; PARTICLE SIZE; PREDICTIVE VALUE OF TESTS; TISSUE DISTRIBUTION; VERAPAMIL;

EID: 0037028044     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00294-8     Document Type: Article

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