Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging

Biomaterials

Volumn 33, Issue 11, 2012, Pages 3071-3082

  Xiao, Yuling ^a   Hong, Hao ^a   Javadi, Alireza ^a   Engle, Jonathan W ^b   Xu, Wenjin ^a   Yang, Yunan ^a   Zhang, Yin ^b   Barnhart, Todd E ^b   Cai, Weibo ^a,b,c   Gong, Shaoqin ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Cyclic arginine glycine aspartic acid (cRGD) peptide; Drug delivery; Hyperbranched amphiphilic block copolymer; Positron emission tomography (PET); Theranostic nanocarriers; Unimolecular micelles

Indexed keywords

AMPHIPHILIC BLOCK COPOLYMERS; ANTICANCER DRUG; BIODISTRIBUTIONS; CELLULAR UPTAKE; DOXORUBICIN; DRUG RELEASE; EX-VIVO; FLUORESCENCE IMAGING; GLIOBLASTOMA CELLS; HYDRAZONES; HYDROPHOBIC SEGMENT; HYPERBRANCHED; INTEGRINS; MACROCYCLICS; NANOCARRIERS; NON-INVASIVE; NON-TARGETED; PET IMAGING; PH SENSITIVE; POSITRON EMISSION; THERANOSTICS; TUMOR ACCUMULATION; UNIMOLECULAR MICELLES;

AMINO ACIDS; BLOCK COPOLYMERS; DISEASES; DRUG DELIVERY; MAMMALS; MOLECULAR BIOLOGY; PEPTIDES; POLYETHYLENE GLYCOLS; POSITRON EMISSION TOMOGRAPHY; TUMORS;

MICELLES;

1,4,7 TRIAZACYCLONONANE N',N',N'' TRIACETIC ACID; ARGININE; ASPARTIC ACID; CHELATING AGENT; COPOLYMER; COPPER 64; CYCLIC ARGININE GLYCINE ASPARTIC ACID; CYSTEINE; DOXORUBICIN; GLYCINE; H40 POLY(GLUTAMATE HYDRAZONE DOXORUBICIN) B POLY(ETHYLENE GLYCOL); HYDRAZONE DERIVATIVE; INTEGRIN; PHENYLALANINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED DRUG RELEASE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; EX VIVO STUDY; FEMALE; FLUORESCENCE IMAGING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MICELLE; MOUSE; NONHUMAN; PH; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SYNTHESIS; UNIMOLECULAR MICELLE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; DOXORUBICIN; DRUG CARRIERS; GLIOBLASTOMA; HUMANS; MICE; MICELLES; POSITRON-EMISSION TOMOGRAPHY; TREATMENT OUTCOME;

MUS;

EID: 84862798517     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.12.030     Document Type: Article

References (55)

1. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
2. Cai W., Chen X. Nanoplatforms for targeted molecular imaging in living subjects. Small 2007, 3:1840-1854.
3. Hong H., Zhang Y., Sun J., Cai W. Molecular imaging and therapy of cancer with radiolabeled nanoparticles. Nano Today 2009, 4:399-413.
4. van Vlerken L.E., Vyas T.K., Amiji M.M. Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery. Pharm Res 2007, 24:1405-1414.
5. Jain R.K., Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol 2010, 7:653-664.
6. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 2005, 5:161-171.
7. Cabral H., Nishiyama N., Kataoka K. Supramolecular nanodevices: from design validation to theranostic nanomedicine. Acc Chem Res 2011, 44:999-1008.
8. Rosi N.L., Mirkin C.A. Nanostructures in biodiagnostics. Chem Rev 2005, 105:1547-1562.
9. Williams D.F. On the nature of biomaterials. Biomaterials 2009, 30:5897-5909.
10. Kim K., Kim J.H., Park H., Kim Y.S., Park K.S., Nam H., et al. Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring. JControl Release 2010, 146:219-227.
11. Nasongkla N, Bey E, Ren J, Ai H, Khemtong C, Guthi JS, etal. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett 6:2427-2430.
12. 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials 2011, 32:4151-4160.
13. Nasongkla N., Shuai X.T., Ai H., Weinberg B.D., Pink J., Boothman D.A., et al. cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem Int Ed Engl 2004, 43:6323-6327.
14. Oerlemans C., Bult W., Bos M., Storm G., Nijsen J.F., Hennink W.E. Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res 2010, 27:2569-2589.
15. Torchilin V.P. Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 2007, 24:1-16.
16. Gao G.H., Lee J.W., Nguyen M.K., Im G.H., Yang J., Heo H., et al. pH-responsive polymeric micelle based on PEG-poly(β-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area. JControl Release 2011, 155:11-17.
17. Yokoyama M. Polymeric micelles as a new drug carrier system and their required considerations for clinical trials. Expert Opin Drug Deliv 2010, 7:145-158.
18. Mishra D., Kang H.C., Bae Y.H. Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery. Biomaterials 2011, 32:3845-3854.
19. Blanco E., Bey E.A., Khemtong C., Yang S.G., Setti-Guthi J., Chen H.B., et al. β-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. Cancer Res 2010, 70:3896-3904.
20. Wei H., Zhang X.Z., Zhou Y., Cheng S.X., Zhuo R.X. Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate). Biomaterials 2006, 27:2028-2034.
21. Hall D.G., Pethica B.A. Thermodynamics of micelle formation. Nonionic surfactants 1967, 516-557. Marcel Dekker, New York. M.J. Schick (Ed.).
22. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S.Q. Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery. Biomaterials 2009, 30:5757-5766.
23. Nishiyama N., Kataoka K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther 2006, 112:630-648.
24. Talelli M., Iman M., Varkouhi A.K., Rijcken C.J., Schiffelers R.M., Etrych T., et al. Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials 2010, 31:7797-7804.
25. Kim S., Shi Y.Z., Kim J.Y., Park K., Cheng J.X. Overcoming the barriers in micellar drug delivery: loading efficiency, invivo stability, and micelle-cell interaction. Expert Opin Drug Deliv 2010, 7:49-62.
26. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S.Q. Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn H40, poly(L-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery. Biomaterials 2009, 30(16):3009-3019.
27. Li X.J., Qian Y.F., Liu T., Hu X.L., Zhang G.Y., You Y.Z., et al. Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging. Biomaterials 2011, 32:6595-6605.
28. Pang Y., Liu J.Y., Su Y., Zhu B.S., Huang W., Zhou Y.F., et al. Bioreducible unimolecular micelles based on amphiphilic multiarm hyperbranched copolymers for triggered drug release. Sci China-Chem 2010, 53:2497-2508.
29. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S.Q. Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery. Biomaterials 2009, 30:6065-6075.
30. Yang X., Grailer J.J., Rowland I.J., Javadi A., Hurley S.A., Matson V.Z., et al. Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging. ACS Nano 2010, 4:6805-6817.
31. Massoud T.F., Gambhir S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 2003, 17:545-580.
32. Weissleder R., Pittet M.J. Imaging in the era of molecular oncology. Nature 2008, 452:580-589.
33. Phelps M.E. PET: the merging of biology and imaging into molecular imaging. JNucl Med 2000, 41:661-681.
34. 64Cu loaded liposomes as positron emission tomography imaging agents. Biomaterials 2011, 32:2334-2341.
35. Burns A.A., Vider J., Ow H., Herz E., Penate-Medina O., Baumgart M., et al. Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano Lett 2009, 9:442-448.
36. Xie J., Chen K., Huang J., Lee S., Wang J.H., Gao J.H., et al. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 2010, 31:3016-3022.
37. Cai W., Chen X. Multimodality molecular imaging of tumor angiogenesis. JNucl Med 2008, 49(Suppl. 2):113S-128S.
38. Cai W., Niu G., Chen X. Imaging of integrins as biomarkers for tumor angiogenesis. Curr Pharm Des 2008, 14:2943-2973.
39. Cai W., Shin D.W., Chen K., Gheysens O., Cao Q., Wang S.X., et al. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett 2006, 6:669-676.
40. Folkman J. Tumor angiogenesis: therapeutic implications. NEngl J Med 1971, 285:1182-1186.
41. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002, 29(6 Suppl. 16):15-18.
42. Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov 2007, 6:273-286.
43. Abdollahi A., Griggs D.W., Zieher H., Roth A., Lipson K.E., Saffrich R., et al. Inhibition of alpha v beta 3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res 2005, 11:6270-6279.
44. Wang Y., Wang X., Zhang Y., Yang S., Wang J., Zhang X., et al. RGD-modified polymeric micelles as potential carriers for targeted delivery to integrin-overexpressing tumor vasculature and tumor cells. JDrug Target 2009, 17:459-467.
45. Yin J., Li Z., Yang T., Wang J., Zhang X., Zhang Q. Cyclic RGDyK conjugation facilitates intracellular drug delivery of polymeric micelles to integrin-overexpressing tumor cells and neovasculature. JDrug Target 2011, 19:25-36.
46. 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3. Cancer Res 2006, 66:9673-9681.
47. Xiong X.B., Huang Y., Lu W.L., Zhang X., Zhang H., Nagai T., et al. Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic. JControl Release 2005, 107:262-275.
48. Cai W., Chen K., Mohamedali K.A., Cao Q., Gambhir S.S., Rosenblum M.G., et al. PET of vascular endothelial growth factor receptor expression. JNucl Med 2006, 47:2048-2056.
49. Hong H., Benink H.A., Zhang Y., Yang Y., Uyeda H.T., Engle J.W., et al. HaloTag: a novel reporter gene for positron emission tomography. Am J Transl Res 2011, 3:392-403.
50. Hong H., Yang Y., Zhang Y., Engle J.W., Barnhart T.E., Nickles R.J., et al. Positron emission tomography imaging of CD105 expression during tumor angiogenesis. Eur J Nucl Med Mol Imaging 2011, 38:1335-1343.
51. 89Zr-Df-TRC105. Eur J Nucl Med Mol Imaging 2012, 39:138-148.
52. Kreutzer G., Ternat C., Nguyen T.Q., Plummer C.J.G., Manson J.A.E., Castelletto V., et al. Water-soluble, unimolecular containers based on amphiphilic multiarm star block copolymers. Macromolecules 2006, 39:4507-4516.
53. Bae Y.H., Jang W.D., Nishiyama N., Fukushima S., Kataoka K. Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol Biosyst 2005, 1:242-250.
54. Cai W., Chen K., Li Z.B., Gambhir S.S., Chen X. Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. JNucl Med 2007, 48:1862-1870.
55. Liu Z., Cai W., He L., Nakayama N., Chen K., Sun X., et al. Invivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol 2007, 2:47-52.