Prolongation of life in rats with malignant glioma by intranasal siRNA/drug codelivery to the brain with cell-penetrating peptide-modified micelles

Molecular Pharmaceutics

Volumn 11, Issue 5, 2014, Pages 1471-1478

  Kanazawa, Takanori ^a   Morisaki, Kazuki ^a   Suzuki, Shohei ^a   Takashima, Yuuki ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

cell penetrating peptide; malignant glioma; micelles; nose to brain delivery; siRNA

Indexed keywords

CAMPTOTHECIN; CELL PENETRATING PEPTIDE; COPOLYMER; MPEG PCL TAT; NITROGEN; PHOSPHORUS; RAF PROTEIN; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MICELLE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; RAF-1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN; BRAIN TISSUE; CELL DEATH; CELL TRANSPORT; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SAFETY; DRUG STABILITY; GENE EXPRESSION; GLIOBLASTOMA; GLIOMA CELL; MALE; MICELLE; NONHUMAN; NOSE; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; TUMOR XENOGRAFT; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; GLIOMA; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN; CAMPTOTHECIN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; DISEASE MODELS, ANIMAL; GLIOMA; MALE; MAP KINASE KINASE KINASES; MICELLES; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

EID: 84899854672     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400644e     Document Type: Article

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