Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4442-4452

  Knez, Damijan ^a   Brus, Boris ^a,f   Coquelle, Nicolas ^b,c,d   Sosič, Izidor ^a   Šink, Roman ^a   Brazzolotto, Xavier ^e   Mravljak, Janez ^a   Colletier, Jacques Philippe ^b,c,d   Gobec, Stanislav ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIV GRENOBLE ALPES   (France)

^c CNRS   (France)

^d DIF   (France)

^e INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^f Sandoz Biopharmaceuticals Mengeš ^*  (Slovenia)

Author keywords

Alzheimers disease; Butyrylcholinesterase; Chelation; Multifunctional ligands; Nitroxoline

Indexed keywords

8 QUINOLINOL; AMYLOID BETA PROTEIN[1-42]; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COPPER ION; N [[1 (2,3 DIHYDRO 1H INDEN 2 YL)PIPERIDIN 3 YL]METHYL] 8 HYDROXY 5 NITROQUINOLINE 7 CARBOXAMIDE; N [[1 (2,3 DIHYDRO 1H INDEN 2 YL)PIPERIDIN 3 YL]METHYL] 8 HYDROXY N (2 METHOXYETHYL) 5 NITROQUINOLINE 7 CARBOXAMIDE; N [[1 (BENZO[D]THIAZOL 2 YL)PIPERIDIN 3 YL]METHYL] 8 HYDROXY 5 NITROQUINOLINE 7 CARBOXAMIDE; N [[1 (BENZO[D]THIAZOL 2 YLMETHYL)PIPERIDIN 3 YL]METHYL] 8 HYDROXY 5 NITROQUINOLINE 7 CARBOXAMIDE; N [[1 (BENZO[D]THIAZOL 2 YLMETHYL)PIPERIDIN 4 YL]METHYL] 8 HYDROXY N (2 METHOXYETHYL) 5 NITROQUINOLINE 7 CARBOXAMIDE; N [[1 (BENZ[D]OXAZOL 2 YL)PIPERIDIN 3 YL]METHYL] 8 HYDROXY 5 NITROQUINOLINE 7 CARBOXAMIDE; N [[1 (BENZ[D]OXAZOL 2 YLMETHYL)PIPERIDIN 4 YL]METHYL] 8 HYDROXY N (2 METHOXYETHYL) 5 NITROQUINOLINE 7 CARBOXAMIDE; NITROXOLINE DERIVATIVE; QUERCETIN; TACRINE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CHELATING AGENT; METAL; NITROQUINOLINE DERIVATIVE; NITROXOLINE; PEPTIDE FRAGMENT; PROTEIN BINDING;

ANTI AGGREGATION ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHELATION; CHOLINERGIC ACTIVITY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC50; PROTEIN ASSEMBLY; STRUCTURE ACTIVITY RELATION; ALZHEIMER DISEASE; BINDING SITE; CHEMISTRY; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BINDING SITES; BUTYRYLCHOLINESTERASE; CHELATING AGENTS; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; METALS; MOLECULAR DOCKING SIMULATION; NITROQUINOLINES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84937816043     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.06.010     Document Type: Article

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