Development of new cathepsin b inhibitors: Combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives

Journal of Medicinal Chemistry

Volumn 56, Issue 2, 2013, Pages 521-533

  Sosič, Izidor ^a   Mirković, Bojana ^a   Arenz, Katharina ^a   Štefane, Bogdan ^a,b   Kos, Janko ^a,c   Gobec, Stanislav ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b EN FIST CENTRE OF EXCELLENCE   (Slovenia)

^c JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[(8 HYDROXY 5 NITROQUINOLIN 7 YL)METHYL]AMINO]ACETONITRILE; 2 [BENZYL[(8 HYDROXY 5 NITROQUINOLIN 7 YL)METHYL]AMINO]ACETONITRILE; 2 BROMO 4 NITRO 1 AMINONAPHTHALENE; 4 NITRONAPHTHALEN 1 YL METHANESULFONATE; 4 NITRONAPHTHALENE 1 PYRROLIDINE; 5 NITROQUINOLONE; 8 (4 METHYLPIPERIDIN 1 YL) 5 NITROQUINOLINE; 8 ACETAMIDO 5 NITROQUINOLINE; 8 ACETAMIDOXY 5 NITROQUINOLINE; 8 AMINO 5 NITROQUINOLINE; 8 AMINOQUINOLINE; 8 CYANOMETHOXY 5 NITROQUINOLINE; 8 CYANOMETHOXYQUINOLINE; CATHEPSIN B INHIBITOR; NITROXOLINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

CATHEPSIN B; CYSTEINE PROTEINASE INHIBITORS; NITROQUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872760912     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301544x     Document Type: Article

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