Novel Mechanism of CathepsinB Inhibition by Antibiotic Nitroxoline and Related Compounds

ChemMedChem

Volumn 6, Issue 8, 2011, Pages 1351-1356

  Mirković, Bojana ^a   Renko, Miha ^b   Turk, Samo ^a   Sosič, Izidor ^a   Jevnikar, Zala ^a   Obermajer, Nataša ^a,b   Turk, Dušan ^b   Gobec, Stanislav ^a   Kos, Janko ^a,b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Antitumor agents; Cancer; CathepsinB; Enzyme inhibitors; Nitroxolines

Indexed keywords

ANTINEOPLASTIC AGENT; CATHEPSIN B; CATHEPSIN B INHIBITOR; NITROXOLINE; ANTIINFECTIVE AGENT; CATHEPSIN H; CATHEPSIN L; NITROQUINOLINE DERIVATIVE;

ANTIBIOTIC THERAPY; BINDING AFFINITY; CANCER INVASION; CANCER REGRESSION; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG SOLUBILITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; INHIBITION KINETICS; NONHUMAN; NOTE; PRIORITY JOURNAL; TUMOR GROWTH; URINARY TRACT INFECTION; ARTICLE; BINDING SITE; CELL LINE; CELL MOTION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; CATHEPSIN B; CATHEPSIN H; CATHEPSIN L; CELL LINE; CELL MOVEMENT; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICROSCOPY, FLUORESCENCE; NITROQUINOLINES; SUBSTRATE SPECIFICITY;

EID: 79960676458     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100098     Document Type: Note

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