-
1
-
-
79952747862
-
Alzheimer's disease
-
Ballard, C.; Gauthier, S.; Corbett, A.; Brayne, C.; Aarsland, D.; Jones, E. Alzheimer's disease Lancet 2011, 377, 1019-1031
-
(2011)
Lancet
, vol.377
, pp. 1019-1031
-
-
Ballard, C.1
Gauthier, S.2
Corbett, A.3
Brayne, C.4
Aarsland, D.5
Jones, E.6
-
2
-
-
84868600949
-
Introduction to special issue on Alzheimer's disease
-
Wolfe, M. S. Introduction to special issue on Alzheimer's disease J. Med. Chem. 2012, 55, 8977-8978
-
(2012)
J. Med. Chem.
, vol.55
, pp. 8977-8978
-
-
Wolfe, M.S.1
-
3
-
-
84857977037
-
Alzheimer's disease: Redox dysregulation as a common denominator for diverse pathogenic mechanisms
-
von Bernhardi, R.; Eugenin, J. Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms Antioxid. Redox Signaling 2012, 16, 974-1031
-
(2012)
Antioxid. Redox Signaling
, vol.16
, pp. 974-1031
-
-
Von Bernhardi, R.1
Eugenin, J.2
-
4
-
-
84864934604
-
Antioxidant therapies for Alzheimer's disease
-
Feng, Y.; Wang, X. Antioxidant therapies for Alzheimer's disease Oxid. Med. Cell. Longevity 2012, 2012, 472932
-
(2012)
Oxid. Med. Cell. Longevity
, vol.2012
, pp. 472932
-
-
Feng, Y.1
Wang, X.2
-
5
-
-
56349145099
-
Oxidative stress hypothesis in Alzheimer's disease: A reappraisal
-
Pratico, D. Oxidative stress hypothesis in Alzheimer's disease: a reappraisal Trends Pharmacol. Sci. 2008, 29, 609-615
-
(2008)
Trends Pharmacol. Sci.
, vol.29
, pp. 609-615
-
-
Pratico, D.1
-
6
-
-
79955658979
-
Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: Insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder
-
Sultana, R.; Mecocci, P.; Mangialasche, F.; Cecchetti, R.; Baglioni, M.; Butterfield, D. A. Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder J. Alzheimer's Dis. 2011, 24, 77-84
-
(2011)
J. Alzheimer's Dis.
, vol.24
, pp. 77-84
-
-
Sultana, R.1
Mecocci, P.2
Mangialasche, F.3
Cecchetti, R.4
Baglioni, M.5
Butterfield, D.A.6
-
7
-
-
41149166082
-
Nucleic acid oxidation in Alzheimer disease
-
Moreira, P. I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J. C.; Aliev, G.; Smith, M. A.; Perry, G. Nucleic acid oxidation in Alzheimer disease Free Radical Biol. Med. 2008, 44, 1493-1505
-
(2008)
Free Radical Biol. Med.
, vol.44
, pp. 1493-1505
-
-
Moreira, P.I.1
Nunomura, A.2
Nakamura, M.3
Takeda, A.4
Shenk, J.C.5
Aliev, G.6
Smith, M.A.7
Perry, G.8
-
8
-
-
70349386042
-
Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease
-
Fukuda, M.; Kanou, F.; Shimada, N.; Sawabe, M.; Saito, Y.; Murayama, S.; Hashimoto, M.; Maruyama, N.; Ishigami, A. Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease Biomed. Res. 2009, 30, 227-233
-
(2009)
Biomed. Res.
, vol.30
, pp. 227-233
-
-
Fukuda, M.1
Kanou, F.2
Shimada, N.3
Sawabe, M.4
Saito, Y.5
Murayama, S.6
Hashimoto, M.7
Maruyama, N.8
Ishigami, A.9
-
9
-
-
75149118997
-
Role of oxidative stress in the progression of Alzheimer's disease
-
Sultana, R.; Butterfield, D. A. Role of oxidative stress in the progression of Alzheimer's disease J. Alzheimer's Dis. 2010, 19, 341-353
-
(2010)
J. Alzheimer's Dis.
, vol.19
, pp. 341-353
-
-
Sultana, R.1
Butterfield, D.A.2
-
10
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer's disease
-
Markesbery, W. R. Oxidative stress hypothesis in Alzheimer's disease Free Radical Biol. Med. 1997, 23, 134-147
-
(1997)
Free Radical Biol. Med.
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
11
-
-
84858148877
-
Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease
-
Mecocci, P.; Polidori, M. C. Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease Biochim. Biophys. Acta 2012, 1822, 631-638
-
(2012)
Biochim. Biophys. Acta
, vol.1822
, pp. 631-638
-
-
Mecocci, P.1
Polidori, M.C.2
-
12
-
-
54249124057
-
Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?
-
Becker, R. E.; Greig, N. H.; Giacobini, E. Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices? J. Alzheimer's Dis. 2008, 15, 303-325
-
(2008)
J. Alzheimer's Dis.
, vol.15
, pp. 303-325
-
-
Becker, R.E.1
Greig, N.H.2
Giacobini, E.3
-
13
-
-
84855688858
-
Nanotherapeutics for Alzheimer's disease (AD): Past, present and future
-
Fazil, M.; Shadab; Baboota, S.; Sahni, J. K.; Ali, J. Nanotherapeutics for Alzheimer's disease (AD): past, present and future J. Drug Targeting 2012, 20, 97-113
-
(2012)
J. Drug Targeting
, vol.20
, pp. 97-113
-
-
Fazil, M.1
Shadab2
Baboota, S.3
Sahni, J.K.4
Ali, J.5
-
14
-
-
84863798026
-
Antioxidants for Alzheimer disease: A randomized clinical trial with cerebrospinal fluid biomarker measures
-
Galasko, D. R.; Peskind, E.; Clark, C. M.; Quinn, J. F.; Ringman, J. M.; Jicha, G. A.; Cotman, C.; Cottrell, B.; Montine, T. J.; Thomas, R. G.; Aisen, P. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures Arch. Neurol. 2012, 69, 836-841
-
(2012)
Arch. Neurol.
, vol.69
, pp. 836-841
-
-
Galasko, D.R.1
Peskind, E.2
Clark, C.M.3
Quinn, J.F.4
Ringman, J.M.5
Jicha, G.A.6
Cotman, C.7
Cottrell, B.8
Montine, T.J.9
Thomas, R.G.10
Aisen, P.11
-
15
-
-
84876832340
-
Target- and mechanism-based therapeutics for neurodegenerative diseases: Strength in numbers
-
Trippier, P. C.; Jansen Labby, K.; Hawker, D. D.; Mataka, J. J.; Silverman, R. B. Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers J. Med. Chem. 2013, 56, 3121-3147
-
(2013)
J. Med. Chem.
, vol.56
, pp. 3121-3147
-
-
Trippier, P.C.1
Jansen Labby, K.2
Hawker, D.D.3
Mataka, J.J.4
Silverman, R.B.5
-
16
-
-
33745815173
-
Multipotent antioxidants: From screening to design
-
Zhang, H. Y.; Yang, D. P.; Tang, G. Y. Multipotent antioxidants: from screening to design Drug Discovery Today 2006, 11, 749-754
-
(2006)
Drug Discovery Today
, vol.11
, pp. 749-754
-
-
Zhang, H.Y.1
Yang, D.P.2
Tang, G.Y.3
-
17
-
-
39149091398
-
Multi-target-directed ligands to combat neurodegenerative diseases
-
Cavalli, A.; Bolognesi, M. L.; Minarini, A.; Rosini, M.; Tumiatti, V.; Recanatini, M.; Melchiorre, C. Multi-target-directed ligands to combat neurodegenerative diseases J. Med. Chem. 2008, 51, 347-372
-
(2008)
J. Med. Chem.
, vol.51
, pp. 347-372
-
-
Cavalli, A.1
Bolognesi, M.L.2
Minarini, A.3
Rosini, M.4
Tumiatti, V.5
Recanatini, M.6
Melchiorre, C.7
-
18
-
-
67649865357
-
Alzheimer's disease: New approaches to drug discovery
-
Bolognesi, M. L.; Matera, R.; Minarini, A.; Rosini, M.; Melchiorre, C. Alzheimer's disease: new approaches to drug discovery Curr. Opin. Chem. Biol. 2009, 13, 303-308
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 303-308
-
-
Bolognesi, M.L.1
Matera, R.2
Minarini, A.3
Rosini, M.4
Melchiorre, C.5
-
19
-
-
84876820944
-
Antioxidant hybrid compounds: A promising therapeutic intervention in oxidative stress induced diseases
-
Tailor, N.; Sharma, M. Antioxidant hybrid compounds: a promising therapeutic intervention in oxidative stress induced diseases Mini-Rev. Med. Chem. 2013, 13, 280-297
-
(2013)
Mini-Rev. Med. Chem.
, vol.13
, pp. 280-297
-
-
Tailor, N.1
Sharma, M.2
-
20
-
-
42649131760
-
The neuroprotective mechanism of action of the multimodal drug ladostigil
-
Weinreb, O.; Amit, T.; Bar-Am, O.; Yogev-Falach, M.; Youdim, M. B the neuroprotective mechanism of action of the multimodal drug ladostigil Front. Biosci. 2008, 13, 5131-5137
-
(2008)
Front. Biosci.
, vol.13
, pp. 5131-5137
-
-
Weinreb, O.1
Amit, T.2
Bar-Am, O.3
Yogev-Falach, M.4
Youdim, M.B.5
-
21
-
-
84857709982
-
Ladostigil: A novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment
-
Weinreb, O.; Amit, T.; Bar-Am, O.; Youdim, M. B. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment Curr. Drug Targets 2012, 13, 483-494
-
(2012)
Curr. Drug Targets
, vol.13
, pp. 483-494
-
-
Weinreb, O.1
Amit, T.2
Bar-Am, O.3
Youdim, M.B.4
-
22
-
-
18744414554
-
Acetylcholinesterase: "classical" and "non-classical" functions and pharmacology
-
Silman, I.; Sussman, J. L. Acetylcholinesterase: "classical" and "non-classical" functions and pharmacology Curr. Opin. Pharmacol. 2005, 5, 293-302
-
(2005)
Curr. Opin. Pharmacol.
, vol.5
, pp. 293-302
-
-
Silman, I.1
Sussman, J.L.2
-
23
-
-
56049122716
-
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): A step forward in the treatment of Alzheimer's disease
-
Bolognesi, M. L.; Minarini, A.; Rosini, M.; Tumiatti, V.; Melchiorre, C. From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease Mini-Rev. Med. Chem. 2008, 8, 960-967
-
(2008)
Mini-Rev. Med. Chem.
, vol.8
, pp. 960-967
-
-
Bolognesi, M.L.1
Minarini, A.2
Rosini, M.3
Tumiatti, V.4
Melchiorre, C.5
-
24
-
-
55249106710
-
Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease
-
Munoz-Torrero, D. Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease Curr. Med. Chem. 2008, 15, 2433-2455
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 2433-2455
-
-
Munoz-Torrero, D.1
-
25
-
-
38549098085
-
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease
-
Inestrosa, N. C.; Dinamarca, M. C.; Alvarez, A. Amyloid-cholinesterase interactions. Implications for Alzheimer's disease FEBS J. 2008, 275, 625-632
-
(2008)
FEBS J.
, vol.275
, pp. 625-632
-
-
Inestrosa, N.C.1
Dinamarca, M.C.2
Alvarez, A.3
-
26
-
-
33750883640
-
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
-
Castro, A.; Martinez, A. Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors Curr. Pharm. Des. 2006, 12, 4377-4387
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 4377-4387
-
-
Castro, A.1
Martinez, A.2
-
27
-
-
12344328416
-
Rational approach to discover multipotent anti-Alzheimer drugs
-
Rosini, M.; Andrisano, V.; Bartolini, M.; Bolognesi, M. L.; Hrelia, P.; Minarini, A.; Tarozzi, A.; Melchiorre, C. Rational approach to discover multipotent anti-Alzheimer drugs J. Med. Chem. 2005, 48, 360-363
-
(2005)
J. Med. Chem.
, vol.48
, pp. 360-363
-
-
Rosini, M.1
Andrisano, V.2
Bartolini, M.3
Bolognesi, M.L.4
Hrelia, P.5
Minarini, A.6
Tarozzi, A.7
Melchiorre, C.8
-
28
-
-
80054960254
-
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease
-
Rosini, M.; Simoni, E.; Bartolini, M.; Tarozzi, A.; Matera, R.; Milelli, A.; Hrelia, P.; Andrisano, V.; Bolognesi, M. L.; Melchiorre, C. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease Eur. J. Med. Chem. 2011, 46, 5435-5442
-
(2011)
Eur. J. Med. Chem.
, vol.46
, pp. 5435-5442
-
-
Rosini, M.1
Simoni, E.2
Bartolini, M.3
Tarozzi, A.4
Matera, R.5
Milelli, A.6
Hrelia, P.7
Andrisano, V.8
Bolognesi, M.L.9
Melchiorre, C.10
-
29
-
-
0032985492
-
Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue
-
Tirosh, O.; Sen, C. K.; Roy, S.; Kobayashi, M. S.; Packer, L. Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue Free Radical Biol. Med. 1999, 26, 1418-1426
-
(1999)
Free Radical Biol. Med.
, vol.26
, pp. 1418-1426
-
-
Tirosh, O.1
Sen, C.K.2
Roy, S.3
Kobayashi, M.S.4
Packer, L.5
-
30
-
-
80052805320
-
Reversible human serum albumin binding of lipocrine: A circular dichroism study
-
Bertucci, C.; De Simone, A.; Pistolozzi, M.; Rosini, M. Reversible human serum albumin binding of lipocrine: a circular dichroism study Chirality 2011, 23, 827-832
-
(2011)
Chirality
, vol.23
, pp. 827-832
-
-
Bertucci, C.1
De Simone, A.2
Pistolozzi, M.3
Rosini, M.4
-
32
-
-
84887888271
-
Multifunctional tacrine derivatives in Alzheimer's disease
-
Minarini, A.; Milelli, A.; Simoni, E.; Rosini, M.; Bolognesi, M. L.; Marchetti, C.; Tumiatti, V. Multifunctional tacrine derivatives in Alzheimer's disease Curr. Top. Med. Chem. 2013, 13, 1771-1786
-
(2013)
Curr. Top. Med. Chem.
, vol.13
, pp. 1771-1786
-
-
Minarini, A.1
Milelli, A.2
Simoni, E.3
Rosini, M.4
Bolognesi, M.L.5
Marchetti, C.6
Tumiatti, V.7
-
33
-
-
34250872774
-
A small molecule targeting the multifactorial nature of Alzheimer's disease
-
Cavalli, A.; Bolognesi, M. L.; Capsoni, S.; Andrisano, V.; Bartolini, M.; Margotti, E.; Cattaneo, A.; Recanatini, M.; Melchiorre, C. A small molecule targeting the multifactorial nature of Alzheimer's disease Angew. Chem., Int. Ed. 2007, 46, 3689-3692
-
(2007)
Angew. Chem., Int. Ed.
, vol.46
, pp. 3689-3692
-
-
Cavalli, A.1
Bolognesi, M.L.2
Capsoni, S.3
Andrisano, V.4
Bartolini, M.5
Margotti, E.6
Cattaneo, A.7
Recanatini, M.8
Melchiorre, C.9
-
34
-
-
72249110242
-
Toward a rational design of multitarget-directed antioxidants: Merging memoquin and lipoic acid molecular frameworks
-
Bolognesi, M. L.; Cavalli, A.; Bergamini, C.; Fato, R.; Lenaz, G.; Rosini, M.; Bartolini, M.; Andrisano, V.; Melchiorre, C. Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks J. Med. Chem. 2009, 52, 7883-7886
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7883-7886
-
-
Bolognesi, M.L.1
Cavalli, A.2
Bergamini, C.3
Fato, R.4
Lenaz, G.5
Rosini, M.6
Bartolini, M.7
Andrisano, V.8
Melchiorre, C.9
-
35
-
-
49449083763
-
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: A promising direction for the multi-target-directed ligands gold rush
-
Rosini, M.; Simoni, E.; Bartolini, M.; Cavalli, A.; Ceccarini, L.; Pascu, N.; McClymont, D. W.; Tarozzi, A.; Bolognesi, M. L.; Minarini, A.; Tumiatti, V.; Andrisano, V.; Mellor, I. R.; Melchiorre, C. Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush J. Med. Chem. 2008, 51, 4381-4384
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4381-4384
-
-
Rosini, M.1
Simoni, E.2
Bartolini, M.3
Cavalli, A.4
Ceccarini, L.5
Pascu, N.6
McClymont, D.W.7
Tarozzi, A.8
Bolognesi, M.L.9
Minarini, A.10
Tumiatti, V.11
Andrisano, V.12
Mellor, I.R.13
Melchiorre, C.14
-
36
-
-
84855915652
-
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment
-
Minarini, A.; Milelli, A.; Tumiatti, V.; Rosini, M.; Simoni, E.; Bolognesi, M. L.; Andrisano, V.; Bartolini, M.; Motori, E.; Angeloni, C.; Hrelia, S. Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment Neuropharmacology 2012, 62, 997-1003
-
(2012)
Neuropharmacology
, vol.62
, pp. 997-1003
-
-
Minarini, A.1
Milelli, A.2
Tumiatti, V.3
Rosini, M.4
Simoni, E.5
Bolognesi, M.L.6
Andrisano, V.7
Bartolini, M.8
Motori, E.9
Angeloni, C.10
Hrelia, S.11
-
37
-
-
84863144997
-
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-beta-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo
-
Pi, R.; Mao, X.; Chao, X.; Cheng, Z.; Liu, M.; Duan, X.; Ye, M.; Chen, X.; Mei, Z.; Liu, P.; Li, W.; Han, Y. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-beta-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo PLoS One 2012, 7, e31921
-
(2012)
PLoS One
, vol.7
, pp. 31921
-
-
Pi, R.1
Mao, X.2
Chao, X.3
Cheng, Z.4
Liu, M.5
Duan, X.6
Ye, M.7
Chen, X.8
Mei, Z.9
Liu, P.10
Li, W.11
Han, Y.12
-
38
-
-
84898456822
-
-
50) of compound 5: Pi, R. S. Y.-S. U., Guangzhow, China. Personal communication, 2013.
-
(2013)
-
-
Pi, R.S.Y.-S.U.1
-
39
-
-
43849107919
-
Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells
-
Coma, M.; Guix, F. X.; Ill-Raga, G.; Uribesalgo, I.; Alameda, F.; Valverde, M. A.; Munoz, F. J. Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells Neurobiol. Aging 2008, 29, 969-980
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 969-980
-
-
Coma, M.1
Guix, F.X.2
Ill-Raga, G.3
Uribesalgo, I.4
Alameda, F.5
Valverde, M.A.6
Munoz, F.J.7
-
40
-
-
84877072330
-
Amyloid beta-peptide (1-42)-induced oxidative stress in Alzheimer disease: Importance in disease pathogenesis and progression
-
Butterfield, D. A.; Swomley, A. M.; Sultana, R. Amyloid beta-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression Antioxid. Redox Signaling 2013, 19, 823-835
-
(2013)
Antioxid. Redox Signaling
, vol.19
, pp. 823-835
-
-
Butterfield, D.A.1
Swomley, A.M.2
Sultana, R.3
-
41
-
-
67649438788
-
Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease
-
Takeda, S.; Sato, N.; Niisato, K.; Takeuchi, D.; Kurinami, H.; Shinohara, M.; Rakugi, H.; Kano, M.; Morishita, R. Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease Brain Res. 2009, 1280, 137-147
-
(2009)
Brain Res.
, vol.1280
, pp. 137-147
-
-
Takeda, S.1
Sato, N.2
Niisato, K.3
Takeuchi, D.4
Kurinami, H.5
Shinohara, M.6
Rakugi, H.7
Kano, M.8
Morishita, R.9
-
42
-
-
65249178920
-
Botanical phenolics and brain health
-
Sun, A. Y.; Wang, Q.; Simonyi, A.; Sun, G. Y. Botanical phenolics and brain health NeuroMol. Med. 2008, 10, 259-274
-
(2008)
NeuroMol. Med.
, vol.10
, pp. 259-274
-
-
Sun, A.Y.1
Wang, Q.2
Simonyi, A.3
Sun, G.Y.4
-
43
-
-
0034655773
-
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
-
Motterlini, R.; Foresti, R.; Bassi, R.; Green, C. J. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress Free Radical Biol. Med. 2000, 28, 1303-1312
-
(2000)
Free Radical Biol. Med.
, vol.28
, pp. 1303-1312
-
-
Motterlini, R.1
Foresti, R.2
Bassi, R.3
Green, C.J.4
-
44
-
-
84857098192
-
Challenges associated with curcumin therapy in Alzheimer disease
-
Belkacemi, A.; Doggui, S.; Dao, L.; Ramassamy, C. Challenges associated with curcumin therapy in Alzheimer disease Expert Rev. Mol. Med. 2011, 13, e34
-
(2011)
Expert Rev. Mol. Med.
, vol.13
, pp. 34
-
-
Belkacemi, A.1
Doggui, S.2
Dao, L.3
Ramassamy, C.4
-
45
-
-
37549051274
-
Bioavailability of curcumin: Problems and promises
-
Anand, P.; Kunnumakkara, A. B.; Newman, R. A.; Aggarwal, B. B. Bioavailability of curcumin: problems and promises Mol. Pharmaceutics 2007, 4, 807-818
-
(2007)
Mol. Pharmaceutics
, vol.4
, pp. 807-818
-
-
Anand, P.1
Kunnumakkara, A.B.2
Newman, R.A.3
Aggarwal, B.B.4
-
46
-
-
84555177564
-
"clicked" sugar-curcumin conjugate: Modulator of amyloid-beta and tau peptide aggregation at ultralow concentrations
-
Dolai, S.; Shi, W.; Corbo, C.; Sun, C.; Averick, S.; Obeysekera, D.; Farid, M.; Alonso, A.; Banerjee, P.; Raja, K. "Clicked" sugar-curcumin conjugate: modulator of amyloid-beta and tau peptide aggregation at ultralow concentrations ACS Chem. Neurosci. 2011, 2, 694-699
-
(2011)
ACS Chem. Neurosci.
, vol.2
, pp. 694-699
-
-
Dolai, S.1
Shi, W.2
Corbo, C.3
Sun, C.4
Averick, S.5
Obeysekera, D.6
Farid, M.7
Alonso, A.8
Banerjee, P.9
Raja, K.10
-
47
-
-
84874847243
-
Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease
-
Evangelisti, E.; Wright, D.; Zampagni, M.; Cascella, R.; Fiorillo, C.; Bagnoli, S.; Relini, A.; Nichino, D.; Scartabelli, T.; Nacmias, B.; Sorbi, S.; Cecchi, C. Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease Curr. Alzheimer Res. 2013, 10, 143-153
-
(2013)
Curr. Alzheimer Res.
, vol.10
, pp. 143-153
-
-
Evangelisti, E.1
Wright, D.2
Zampagni, M.3
Cascella, R.4
Fiorillo, C.5
Bagnoli, S.6
Relini, A.7
Nichino, D.8
Scartabelli, T.9
Nacmias, B.10
Sorbi, S.11
Cecchi, C.12
-
48
-
-
48549100652
-
Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - A review
-
Ariga, T.; McDonald, M. P.; Yu, R. K. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - a review J. Lipid Res. 2008, 49, 1157-1175
-
(2008)
J. Lipid Res.
, vol.49
, pp. 1157-1175
-
-
Ariga, T.1
McDonald, M.P.2
Yu, R.K.3
-
49
-
-
77955865110
-
"clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: Design, synthesis, and biological characterization
-
Lenhart, J. A.; Ling, X.; Gandhi, R.; Guo, T. L.; Gerk, P. M.; Brunzell, D. H.; Zhang, S. "Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization J. Med. Chem. 2010, 53, 6198-6209
-
(2010)
J. Med. Chem.
, vol.53
, pp. 6198-6209
-
-
Lenhart, J.A.1
Ling, X.2
Gandhi, R.3
Guo, T.L.4
Gerk, P.M.5
Brunzell, D.H.6
Zhang, S.7
-
50
-
-
84863116177
-
Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Abeta plaques in Alzheimer's disease
-
Liu, K.; Guo, T. L.; Chojnacki, J.; Lee, H. G.; Wang, X.; Siedlak, S. L.; Rao, W.; Zhu, X.; Zhang, S. Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Abeta plaques in Alzheimer's disease ACS Chem. Neurosci. 2012, 3, 141-146
-
(2012)
ACS Chem. Neurosci.
, vol.3
, pp. 141-146
-
-
Liu, K.1
Guo, T.L.2
Chojnacki, J.3
Lee, H.G.4
Wang, X.5
Siedlak, S.L.6
Rao, W.7
Zhu, X.8
Zhang, S.9
-
51
-
-
84868680596
-
Bivalent ligands targeting multiple pathological factors involved in Alzheimer's disease
-
Liu, K.; Gandhi, R.; Chen, J.; Zhang, S. Bivalent ligands targeting multiple pathological factors involved in Alzheimer's disease ACS Med. Chem. Lett. 2012, 3, 942-946
-
(2012)
ACS Med. Chem. Lett.
, vol.3
, pp. 942-946
-
-
Liu, K.1
Gandhi, R.2
Chen, J.3
Zhang, S.4
-
52
-
-
4644275696
-
Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
-
Baum, L.; Ng, A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models J. Alzheimer's Dis. 2004, 6, 367-377
-
(2004)
J. Alzheimer's Dis.
, vol.6
, pp. 367-377
-
-
Baum, L.1
Ng, A.2
-
53
-
-
77950360800
-
Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: An AFM study
-
Innocenti, M.; Salvietti, E.; Guidotti, M.; Casini, A.; Bellandi, S.; Foresti, M. L.; Gabbiani, C.; Pozzi, A.; Zatta, P.; Messori, L. Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study J. Alzheimer's Dis. 2010, 19, 1323-1329
-
(2010)
J. Alzheimer's Dis.
, vol.19
, pp. 1323-1329
-
-
Innocenti, M.1
Salvietti, E.2
Guidotti, M.3
Casini, A.4
Bellandi, S.5
Foresti, M.L.6
Gabbiani, C.7
Pozzi, A.8
Zatta, P.9
Messori, L.10
-
54
-
-
63349095579
-
A novel approach to the identification and quantitative elemental analysis of amyloid deposits - Insights into the pathology of Alzheimer's disease
-
Rajendran, R.; Minqin, R.; Ynsa, M. D.; Casadesus, G.; Smith, M. A.; Perry, G.; Halliwell, B.; Watt, F. A novel approach to the identification and quantitative elemental analysis of amyloid deposits - insights into the pathology of Alzheimer's disease Biochem. Biophys. Res. Commun. 2009, 382, 91-95
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.382
, pp. 91-95
-
-
Rajendran, R.1
Minqin, R.2
Ynsa, M.D.3
Casadesus, G.4
Smith, M.A.5
Perry, G.6
Halliwell, B.7
Watt, F.8
-
55
-
-
84865127699
-
Copper and oxidative stress in the pathogenesis of Alzheimer's disease
-
Eskici, G.; Axelsen, P. H. Copper and oxidative stress in the pathogenesis of Alzheimer's disease Biochemistry 2012, 51, 6289-6311
-
(2012)
Biochemistry
, vol.51
, pp. 6289-6311
-
-
Eskici, G.1
Axelsen, P.H.2
-
56
-
-
84878034899
-
Untangling amyloid-beta, tau, and metals in Alzheimer's disease
-
Savelieff, M. G.; Lee, S.; Liu, Y.; Lim, M. H. Untangling amyloid-beta, tau, and metals in Alzheimer's disease ACS Chem. Biol. 2013, 8, 856-865
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 856-865
-
-
Savelieff, M.G.1
Lee, S.2
Liu, Y.3
Lim, M.H.4
-
57
-
-
0030475452
-
Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death
-
Sopher, B. L.; Fukuchi, K.; Kavanagh, T. J.; Furlong, C. E.; Martin, G. M. Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death Mol. Chem. Neuropathol. 1996, 29, 153-168
-
(1996)
Mol. Chem. Neuropathol.
, vol.29
, pp. 153-168
-
-
Sopher, B.L.1
Fukuchi, K.2
Kavanagh, T.J.3
Furlong, C.E.4
Martin, G.M.5
-
58
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin, M. T.; Beal, M. F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 2006, 443, 787-795
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
59
-
-
77956219269
-
Rethinking Alzheimer's disease therapy: Are mitochondria the key?
-
Ankarcrona, M.; Mangialasche, F.; Winblad, B. Rethinking Alzheimer's disease therapy: Are mitochondria the key? J. Alzheimer's Dis. 2010, 20 (Suppl. 2) S579-S590
-
(2010)
J. Alzheimer's Dis.
, vol.20
, Issue.SUPPL. 2
-
-
Ankarcrona, M.1
Mangialasche, F.2
Winblad, B.3
-
60
-
-
57649171115
-
Mitochondrial approaches for neuroprotection
-
Chaturvedi, R. K.; Beal, M. F. Mitochondrial approaches for neuroprotection Ann. N.Y. Acad. Sci. 2008, 1147, 395-412
-
(2008)
Ann. N.Y. Acad. Sci.
, vol.1147
, pp. 395-412
-
-
Chaturvedi, R.K.1
Beal, M.F.2
-
61
-
-
84858281225
-
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics
-
Reddy, P. H.; Tripathi, R.; Troung, Q.; Tirumala, K.; Reddy, T. P.; Anekonda, V.; Shirendeb, U. P.; Calkins, M. J.; Reddy, A. P.; Mao, P.; Manczak, M. Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics Biochim. Biophys. Acta 2012, 1822, 639-649
-
(2012)
Biochim. Biophys. Acta
, vol.1822
, pp. 639-649
-
-
Reddy, P.H.1
Tripathi, R.2
Troung, Q.3
Tirumala, K.4
Reddy, T.P.5
Anekonda, V.6
Shirendeb, U.P.7
Calkins, M.J.8
Reddy, A.P.9
Mao, P.10
Manczak, M.11
-
62
-
-
84868127393
-
From mitochondrial dysfunction to amyloid beta formation: Novel insights into the pathogenesis of Alzheimer's disease
-
Leuner, K.; Muller, W. E.; Reichert, A. S. From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease Mol. Neurobiol. 2012, 46, 186-193
-
(2012)
Mol. Neurobiol.
, vol.46
, pp. 186-193
-
-
Leuner, K.1
Muller, W.E.2
Reichert, A.S.3
-
63
-
-
39149122810
-
Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
-
Reddy, P. H.; Beal, M. F. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease Trends Mol. Med. 2008, 14, 45-53
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 45-53
-
-
Reddy, P.H.1
Beal, M.F.2
-
64
-
-
84856220825
-
Strategies to target mitochondria and oxidative stress by antioxidants: Key points and perspectives
-
Edeas, M. Strategies to target mitochondria and oxidative stress by antioxidants: key points and perspectives Pharm. Res. 2011, 28, 2771-2779
-
(2011)
Pharm. Res.
, vol.28
, pp. 2771-2779
-
-
Edeas, M.1
-
65
-
-
33847071146
-
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
-
Murphy, M. P.; Smith, R. A. Targeting antioxidants to mitochondria by conjugation to lipophilic cations Annu. Rev. Pharmacol. Toxicol. 2007, 47, 629-656
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 629-656
-
-
Murphy, M.P.1
Smith, R.A.2
-
66
-
-
84879409744
-
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
-
Gruber, J.; Fong, S.; Chen, C. B.; Yoong, S.; Pastorin, G.; Schaffer, S.; Cheah, I.; Halliwell, B. Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing Biotechnol. Adv. 2013, 31, 563-592
-
(2013)
Biotechnol. Adv.
, vol.31
, pp. 563-592
-
-
Gruber, J.1
Fong, S.2
Chen, C.B.3
Yoong, S.4
Pastorin, G.5
Schaffer, S.6
Cheah, I.7
Halliwell, B.8
-
67
-
-
79955804832
-
Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
-
Carroll, R. E.; Benya, R. V.; Turgeon, D. K.; Vareed, S.; Neuman, M.; Rodriguez, L.; Kakarala, M.; Carpenter, P. M.; McLaren, C.; Meyskens, F. L., Jr.; Brenner, D. E. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia Cancer Prev. Res. 2011, 4, 354-364
-
(2011)
Cancer Prev. Res.
, vol.4
, pp. 354-364
-
-
Carroll, R.E.1
Benya, R.V.2
Turgeon, D.K.3
Vareed, S.4
Neuman, M.5
Rodriguez, L.6
Kakarala, M.7
Carpenter, P.M.8
McLaren, C.9
Meyskens Jr., F.L.10
Brenner, D.E.11
-
68
-
-
77957902907
-
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents
-
Simoni, E.; Bergamini, C.; Fato, R.; Tarozzi, A.; Bains, S.; Motterlini, R.; Cavalli, A.; Bolognesi, M. L.; Minarini, A.; Hrelia, P.; Lenaz, G.; Rosini, M.; Melchiorre, C. Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents J. Med. Chem. 2010, 53, 7264-7268
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7264-7268
-
-
Simoni, E.1
Bergamini, C.2
Fato, R.3
Tarozzi, A.4
Bains, S.5
Motterlini, R.6
Cavalli, A.7
Bolognesi, M.L.8
Minarini, A.9
Hrelia, P.10
Lenaz, G.11
Rosini, M.12
Melchiorre, C.13
-
69
-
-
1242269408
-
Synthesis of curcumin analogues as potential antioxidant, cancer chemopreventive agents
-
Youssef, K. M.; El-Sherbeny, M. A.; El-Shafie, F. S.; Farag, H. A.; Al-Deeb, O. A.; Awadalla, S. A. Synthesis of curcumin analogues as potential antioxidant, cancer chemopreventive agents Arch. Pharm. (Weinheim, Ger.) 2004, 337, 42-54
-
(2004)
Arch. Pharm. (Weinheim, Ger.)
, vol.337
, pp. 42-54
-
-
Youssef, K.M.1
El-Sherbeny, M.A.2
El-Shafie, F.S.3
Farag, H.A.4
Al-Deeb, O.A.5
Awadalla, S.A.6
-
70
-
-
0027998597
-
Cytotoxic evaluation of some N -acyl and N -acyloxy analogues of 3,5-bis(arylidene)-4-piperidones
-
Dimmock, J. R.; Arora, V. K.; Chen, M.; Allen, T. M.; Kao, G. Y. Cytotoxic evaluation of some N -acyl and N -acyloxy analogues of 3,5-bis(arylidene)-4-piperidones Drug Des. Discovery 1994, 12, 19-28
-
(1994)
Drug Des. Discovery
, vol.12
, pp. 19-28
-
-
Dimmock, J.R.1
Arora, V.K.2
Chen, M.3
Allen, T.M.4
Kao, G.Y.5
-
71
-
-
80555131125
-
Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II
-
Brel, V.; Annereau, J. P.; Vispe, S.; Kruczynski, A.; Bailly, C.; Guilbaud, N. Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II Biochem. Pharmacol. 2011, 82, 1843-1852
-
(2011)
Biochem. Pharmacol.
, vol.82
, pp. 1843-1852
-
-
Brel, V.1
Annereau, J.P.2
Vispe, S.3
Kruczynski, A.4
Bailly, C.5
Guilbaud, N.6
-
72
-
-
0029976387
-
Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers
-
Poduslo, J. F.; Curran, G. L. Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers J. Neurochem. 1996, 66, 1599-1609
-
(1996)
J. Neurochem.
, vol.66
, pp. 1599-1609
-
-
Poduslo, J.F.1
Curran, G.L.2
-
73
-
-
74049133619
-
Subcellular targeting strategies for drug design and delivery
-
Rajendran, L.; Knolker, H. J.; Simons, K. Subcellular targeting strategies for drug design and delivery Nat. Rev. Drug Discovery 2010, 9, 29-42
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 29-42
-
-
Rajendran, L.1
Knolker, H.J.2
Simons, K.3
-
74
-
-
59249102083
-
The wanderings of a free radical
-
Halliwell, B the wanderings of a free radical Free Radical Biol. Med. 2009, 46, 531-542
-
(2009)
Free Radical Biol. Med.
, vol.46
, pp. 531-542
-
-
Halliwell, B.1
-
75
-
-
84885603664
-
Keap calm, and carry on covalently
-
Wilson, A. J.; Kerns, J. K.; Callahan, J. F.; Moody, C. J. Keap calm, and carry on covalently J. Med. Chem. 2013, 56, 7463-7476
-
(2013)
J. Med. Chem.
, vol.56
, pp. 7463-7476
-
-
Wilson, A.J.1
Kerns, J.K.2
Callahan, J.F.3
Moody, C.J.4
-
76
-
-
80051665640
-
Neuroprotective strategies involving ROS in Alzheimer disease
-
Dumont, M.; Beal, M. F. Neuroprotective strategies involving ROS in Alzheimer disease Free Radical Biol. Med. 2011, 51, 1014-1026
-
(2011)
Free Radical Biol. Med.
, vol.51
, pp. 1014-1026
-
-
Dumont, M.1
Beal, M.F.2
-
77
-
-
84878572136
-
Toward clinical application of the Keap1-Nrf2 pathway
-
Suzuki, T.; Motohashi, H.; Yamamoto, M. Toward clinical application of the Keap1-Nrf2 pathway Trends Pharmacol. Sci. 2013, 34, 340-346
-
(2013)
Trends Pharmacol. Sci.
, vol.34
, pp. 340-346
-
-
Suzuki, T.1
Motohashi, H.2
Yamamoto, M.3
-
78
-
-
33845648094
-
Redox regulation of neuronal survival mediated by electrophilic compounds
-
Satoh, T.; Lipton, S. A. Redox regulation of neuronal survival mediated by electrophilic compounds Trends Neurosci. 2007, 30, 37-45
-
(2007)
Trends Neurosci.
, vol.30
, pp. 37-45
-
-
Satoh, T.1
Lipton, S.A.2
-
79
-
-
84863825248
-
Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents
-
Magesh, S.; Chen, Y.; Hu, L. Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Med. Res. Rev. 2012, 32, 687-726
-
(2012)
Med. Res. Rev.
, vol.32
, pp. 687-726
-
-
Magesh, S.1
Chen, Y.2
Hu, L.3
-
80
-
-
84882750579
-
The fumaric acid ester BG-12: A new option in MS therapy
-
Lee, D. H.; Stangel, M.; Gold, R.; Linker, R. A the fumaric acid ester BG-12: a new option in MS therapy Expert Rev. Neurother. 2013, 13, 951-958
-
(2013)
Expert Rev. Neurother.
, vol.13
, pp. 951-958
-
-
Lee, D.H.1
Stangel, M.2
Gold, R.3
Linker, R.A.4
-
81
-
-
79952136166
-
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
-
Linker, R. A.; Lee, D. H.; Ryan, S.; van Dam, A. M.; Conrad, R.; Bista, P.; Zeng, W.; Hronowsky, X.; Buko, A.; Chollate, S.; Ellrichmann, G.; Bruck, W.; Dawson, K.; Goelz, S.; Wiese, S.; Scannevin, R. H.; Lukashev, M.; Gold, R. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway Brain 2011, 134, 678-692
-
(2011)
Brain
, vol.134
, pp. 678-692
-
-
Linker, R.A.1
Lee, D.H.2
Ryan, S.3
Van Dam, A.M.4
Conrad, R.5
Bista, P.6
Zeng, W.7
Hronowsky, X.8
Buko, A.9
Chollate, S.10
Ellrichmann, G.11
Bruck, W.12
Dawson, K.13
Goelz, S.14
Wiese, S.15
Scannevin, R.H.16
Lukashev, M.17
Gold, R.18
-
82
-
-
84874081337
-
Diverse functional roles of reactive cysteines
-
Pace, N. J.; Weerapana, E. Diverse functional roles of reactive cysteines ACS Chem. Biol. 2013, 8, 283-296
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 283-296
-
-
Pace, N.J.1
Weerapana, E.2
-
83
-
-
34648843243
-
Pathologically activated therapeutics for neuroprotection
-
Lipton, S. A. Pathologically activated therapeutics for neuroprotection Nat. Rev. Neurosci. 2007, 8, 803-808
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 803-808
-
-
Lipton, S.A.1
-
84
-
-
58149503243
-
Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation
-
Satoh, T.; Saitoh, S.; Hosaka, M.; Kosaka, K. Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation Biochem. Biophys. Res. Commun. 2009, 379, 537-541
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.379
, pp. 537-541
-
-
Satoh, T.1
Saitoh, S.2
Hosaka, M.3
Kosaka, K.4
-
85
-
-
33747606306
-
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
-
Lo, S. C.; Li, X.; Henzl, M. T.; Beamer, L. J.; Hannink, M. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling EMBO J. 2006, 25, 3605-3617
-
(2006)
EMBO J.
, vol.25
, pp. 3605-3617
-
-
Lo, S.C.1
Li, X.2
Henzl, M.T.3
Beamer, L.J.4
Hannink, M.5
-
86
-
-
84876680052
-
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
-
Hu, L.; Magesh, S.; Chen, L.; Wang, L.; Lewis, T. A.; Chen, Y.; Khodier, C.; Inoyama, D.; Beamer, L. J.; Emge, T. J.; Shen, J.; Kerrigan, J. E.; Kong, A. N.; Dandapani, S.; Palmer, M.; Schreiber, S. L.; Munoz, B. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction Bioorg. Med. Chem. Lett. 2013, 23, 3039-3043
-
(2013)
Bioorg. Med. Chem. Lett.
, vol.23
, pp. 3039-3043
-
-
Hu, L.1
Magesh, S.2
Chen, L.3
Wang, L.4
Lewis, T.A.5
Chen, Y.6
Khodier, C.7
Inoyama, D.8
Beamer, L.J.9
Emge, T.J.10
Shen, J.11
Kerrigan, J.E.12
Kong, A.N.13
Dandapani, S.14
Palmer, M.15
Schreiber, S.L.16
Munoz, B.17
-
87
-
-
84879017773
-
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
-
Marcotte, D.; Zeng, W.; Hus, J. C.; McKenzie, A.; Hession, C.; Jin, P.; Bergeron, C.; Lugovskoy, A.; Enyedy, I.; Cuervo, H.; Wang, D.; Atmanene, C.; Roecklin, D.; Vecchi, M.; Vivat, V.; Kraemer, J.; Winkler, D.; Hong, V.; Chao, J.; Lukashev, M.; Silvian, L. Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism Bioorg. Med. Chem. 2013, 21, 4011-4019
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 4011-4019
-
-
Marcotte, D.1
Zeng, W.2
Hus, J.C.3
McKenzie, A.4
Hession, C.5
Jin, P.6
Bergeron, C.7
Lugovskoy, A.8
Enyedy, I.9
Cuervo, H.10
Wang, D.11
Atmanene, C.12
Roecklin, D.13
Vecchi, M.14
Vivat, V.15
Kraemer, J.16
Winkler, D.17
Hong, V.18
Chao, J.19
Lukashev, M.20
Silvian, L.21
more..
|