메뉴 건너뛰기




Volumn 12, Issue 3, 2014, Pages 239-255

Multi-Target directed drugs: A modern approach for design of new drugs for the treatment of Alzheimer’s disease

Author keywords

Alzheimer s disease; Multi target directed drugs; Neurodegenerative disorders; Rational drug design

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BERBERINE; BETA CARBOLINE DERIVATIVE; BETA SECRETASE; CAFFEIC ACID; CARVEDILOL; CHOLINESTERASE; CYSTAMINE; DONEPEZIL; FERULIC ACID; GALANTAMINE; MELATONIN; MEMANTINE; MONOAMINE OXIDASE B INHIBITOR; NIMODIPINE; RESVERATROL; TACRINE; TACRINE DERIVATIVE; TACRIPYRINE; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 84907485475     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/1570159x1203140511153200     Document Type: Article
Times cited : (158)

References (67)
  • 2
    • 11144245220 scopus 로고    scopus 로고
    • Multi- functional drugs for various CNS targets in the treatment of neurodegenerative disorders
    • Youdim, M. B. H.; Buccafusco, J. J. Multi- functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacol. Sci. 2005, 26, 27-35. doi:10.1016/ j.tips.2004.11.007
    • (2005) Trends Pharmacol. Sci , vol.26 , pp. 27-35
    • Youdim, M.B.H.1    Buccafusco, J.J.2
  • 3
    • 79952730699 scopus 로고    scopus 로고
    • Alzheimer's Disease Facts and Figures
    • Alzheimer's Association. Alzheimer's Disease Facts and Figures. Alzheimer's Dementia 2011, 7, 2-68. doi:10.1016/j.jalz.2011.02. 004
    • (2011) Alzheimer's Dementia , vol.7 , pp. 2-68
  • 4
    • 38949086122 scopus 로고    scopus 로고
    • New Insights for Multifactorial Disease Therapy: The Challenge of the Symbiotic Drugs
    • Barreiro, E. J.; Fraga, C. A. M. New Insights for Multifactorial Disease Therapy: The Challenge of the Symbiotic Drugs. Curr. Drug Ther. 2008, 3, 1-13. DOI: 10.2174/157488508783331225
    • (2008) Curr. Drug Ther , vol.3 , pp. 1-13
    • Barreiro, E.J.1    Fraga, C.A.M.2
  • 5
    • 25844505550 scopus 로고    scopus 로고
    • One-compound-multiple-targets strategy to combat Alzheimer's disease
    • Zhang, H-Y. One-compound-multiple-targets strategy to combat Alzheimer's disease. FEBS Lett. 2005, 579, 5260-5264. doi.org/ 10.1016/j.febslet.2005.09.006
    • (2005) FEBS Lett , vol.579 , pp. 5260-5264
    • Zhang, H.-Y.1
  • 6
    • 49449083763 scopus 로고    scopus 로고
    • Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush
    • Cavalli, A.; Bolognesi, M. L.; Minarini, A.; Rosini, M.; Tumiatti, V.; Recanatini, M.; Melchiorre, C. Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush. J. Med. Chem. 2008, 51, 4381-4384. DOI: 10.1021/ jm800577j
    • (2008) J. Med. Chem , vol.51 , pp. 4381-4384
    • Cavalli, A.1    Bolognesi, M.L.2    Minarini, A.3    Rosini, M.4    Tumiatti, V.5    Recanatini, M.6    Melchiorre, C.7
  • 7
    • 0031855023 scopus 로고    scopus 로고
    • The case described by Alois Alzheimer in 1911
    • Moller, H. J.; Graeber, M. B. The case described by Alois Alzheimer in 1911. Eur. Arch. Psychiatry Clin. Neurosci. 1998, 248, 111-122. 111doi.org/10.1007/s004060050027
    • (1998) Eur. Arch. Psychiatry Clin. Neurosci , vol.248 , pp. 111-122
    • Moller, H.J.1    Graeber, M.B.2
  • 8
    • 84873534946 scopus 로고    scopus 로고
    • [Accessed on: August, 2013]. Accessed: 08/ 2012
    • Site of the Brazilian Institute of Geography and Statistics. Available in: http://biblioteca.ibge.gov.br/visualizacao/periodicos/93/cd_2010_ caracteristicas_populacao_domicilios.pdf. [Accessed on: August, 2013]. Available in:. Accessed: 08/ 2012
    • Site of the Brazilian Institute of Geography and Statistics
  • 9
    • 84924201348 scopus 로고    scopus 로고
    • [Accessed on: August, 2013]
    • Site of Alzheimer Med. Available in: http://www.alzheimermed. com.br/conceitos/aspectos-socioeconomicos. [Accessed on: August, 2013]
    • Site of Alzheimer Med
  • 10
    • 84880065255 scopus 로고    scopus 로고
    • Alzheimer's Disease Facts and Figures
    • Alzheimer's Association. Alzheimer's Disease Facts and Figures. Alzheimer's Dementia, 2011, 7, 2.
    • (2011) Alzheimer's Dementia , vol.7 , pp. 2
  • 12
    • 84922835082 scopus 로고    scopus 로고
    • [Accessed on: August, 2012]
    • Alzheimers Association. Available in: http://www.alz.org/ downloads/Facts_Figures_2012.pdf. [Accessed on: August, 2012].
    • Alzheimers Association
  • 13
    • 85027946376 scopus 로고    scopus 로고
    • Progress in the development of new drugs in Alzheimer's disease
    • Piau, A.; Nourhashemi, F.; Hein, C.; Caillaud, C.; Vellas, B. Progress in the development of new drugs in Alzheimer's disease. J. Nutr. Health Aging 2011, 15, 45-57. doi.org/10.1007/s12603-011- 0012-x
    • (2011) J. Nutr. Health Aging , vol.15 , pp. 45-57
    • Piau, A.1    Nourhashemi, F.2    Hein, C.3    Caillaud, C.4    Vellas, B.5
  • 16
    • 84873534946 scopus 로고    scopus 로고
    • [Accessed on: August, 2013]
    • Site of the Brazilian Institute of Geography and Statistics. Available in: http://www.ibge.gov.br/home/estatistica/populacao/ censo2000/populacao/censo2000_populacao.pdf. [Accessed on: August, 2013].
    • Site of the Brazilian Institute of Geography and Statistics
  • 17
    • 80052567229 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease
    • Chen, S. Y.; Chen, Y.; Li, Y. P.; Chen, S. H.; Tan, J. H.; Ou, T. M.; Gu, L. Q.; Huang, Z. S. Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. Bioorg. Med. Chem. 2011, 19, 5596-5604. doi.org/10.1016/j.bmc.2011.07.033
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 5596-5604
    • Chen, S.Y.1    Chen, Y.2    Li, Y.P.3    Chen, S.H.4    Tan, J.H.5    Ou, T.M.6    Gu, L.Q.7    Huang, Z.S.8
  • 18
    • 68849128791 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease: Different molecular targets and potential therapeutic agents including curcumin
    • Ray, B.; Lahiri, D. K. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr. Opin. Pharmacol. 2009, 9, 434-444.
    • (2009) Curr. Opin. Pharmacol , vol.9 , pp. 434-444
    • Ray, B.1    Lahiri, D.K.2
  • 20
  • 21
    • 53549088327 scopus 로고    scopus 로고
    • Portal to Alzheimer's disease
    • Starkov, A. A.; Beal, F. M. Portal to Alzheimer's disease. Nat. Med. 2008, 14, 1020-1021.
    • (2008) Nat. Med , vol.14 , pp. 1020-1021
    • Starkov, A.A.1    Beal, F.M.2
  • 22
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
    • Reddy, P. H.; Beal, M. F. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol. Med. 2008, 14, 45-53. doi. org/10.1016/j.molmed.2007.12.002
    • (2008) Trends Mol. Med , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 23
    • 33846212717 scopus 로고    scopus 로고
    • Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
    • Wang, J. Z.; Grundke-Iqbal, I.; Iqbal, K. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur. J. Neurosci. 2007, 25, 59-68. DOI: 10.1111/j.1460-9568. 2006.05226.x
    • (2007) Eur. J. Neurosci , vol.25 , pp. 59-68
    • Wang, J.Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 24
    • 33746310315 scopus 로고    scopus 로고
    • Plasma Aβ in Alzheimer's disease-up or down?
    • Blennow, K.; de Leon, M. J.; Zetterberg, H. Plasma Aβ in Alzheimer's disease-up or down? Lancet 2006, 368, 387-388.
    • (2006) Lancet , vol.368 , pp. 387-388
    • Blennow, K.1    de Leon, M.J.2    Zetterberg, H.3
  • 27
    • 34548287996 scopus 로고    scopus 로고
    • Oxidative stress: A dead end or a laboratory hypothesis?
    • Azzi, A. Oxidative stress: A dead end or a laboratory hypothesis? Biochem. Biophys. Res. Comm. 2007, 362, 230-232. DOI: 10.1016/ j.bbrc.2007.07.124
    • (2007) Biochem. Biophys. Res. Comm , vol.362 , pp. 230-232
    • Azzi, A.1
  • 28
    • 82455164113 scopus 로고    scopus 로고
    • Neurodegenerative diseases: An alternative path to reduce neuroinflammation
    • Legg, K. Neurodegenerative diseases: An alternative path to reduce neuroinflammation. Nat. Rev. Drug Disc. 2011, 10, 901-910. doi:10. 1038/nrd3607
    • (2011) Nat. Rev. Drug Disc , vol.10 , pp. 901-910
    • Legg, K.1
  • 29
    • 33745726690 scopus 로고    scopus 로고
    • Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)
    • Gaggelli, E.; Kozlowski, H.; Valensin, G. Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis) Chem. Rev. 2006, 106, 1995-2044.
    • (2006) Chem. Rev , vol.106 , pp. 1995-2044
    • Gaggelli, E.1    Kozlowski, H.2    Valensin, G.3
  • 31
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • Heneka, M. T.; O'Banion, M. K. Inflammatory processes in Alzheimer's disease. J. Neuroimmunol. 2007, 184, 69-91. doi:10. 1016/j.jneuroim.2006.11.017
    • (2007) J. Neuroimmunol , vol.184 , pp. 69-91
    • Heneka, M.T.1    O'Banion, M.K.2
  • 33
    • 67651123211 scopus 로고    scopus 로고
    • Anti-Inflammatory Properties of Acetylcholinesterase Inhibitors Administred in Alzheimer's Disease
    • Kamal, M. A.; Greig, N. H.; Reale, M. Anti-Inflammatory Properties of Acetylcholinesterase Inhibitors Administred in Alzheimer's Disease Anti-inflamm. Anti-Allergy Med. Chem. 2009, 8, 85-100. DOI: 10.2174/187152309787580810
    • (2009) Anti-inflamm. Anti-Allergy Med. Chem , vol.8 , pp. 85-100
    • Kamal, M.A.1    Greig, N.H.2    Reale, M.3
  • 34
    • 77953518555 scopus 로고    scopus 로고
    • Alzheimer's disease: Clinical trials and drug development
    • Mangialasche, F.; Solomon, A.; Winblad, B.; Mecocci, P.; Kivipelto, M. Alzheimer's disease: clinical trials and drug development. Lancet Neurol. 2010, 9, 702-716. doi.org/10.1016/S1474-4422(10) 70119-8
    • (2010) Lancet Neurol , vol.9 , pp. 702-716
    • Mangialasche, F.1    Solomon, A.2    Winblad, B.3    Mecocci, P.4    Kivipelto, M.5
  • 35
    • 11144245220 scopus 로고    scopus 로고
    • Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
    • Youdim, M.B.H.; Buccafusco, J. J. Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacol. Sci. 2005, 26, 27-35. doi.org/10.1016/ j.tips.2004.11.007
    • (2005) Trends Pharmacol. Sci , vol.26 , pp. 27-35
    • Youdim, M.B.H.1    Buccafusco, J.J.2
  • 37
    • 85027946376 scopus 로고    scopus 로고
    • Progress in the development of new drugs in Alzheimer's disease
    • Piau, A.; Nourhashemmi, F.; Hein, C.; Caillaud, C.; Vellas, B. Progress in the development of new drugs in Alzheimer's disease, J. Nut. Health Aging 2010, 15, 45-57. doi.org/10.1007/s12603-011- 0012-x
    • (2010) J. Nut. Health Aging , vol.15 , pp. 45-57
    • Piau, A.1    Nourhashemmi, F.2    Hein, C.3    Caillaud, C.4    Vellas, B.5
  • 39
    • 78650757374 scopus 로고    scopus 로고
    • Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3- carbonitriles
    • Samadi, A.; Valderas, C.; de los Rios, C.; Bastida, A.; Chioua, M.; Gonzalez-Lafuente, L.; Colmena, I.; Gandia, L.; Romero, A.; del Barrio, L.; Martin-de-Saavedra, M. D.; Lopez, M.G.; Villarroya, M.; Contelles, J. M. Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3- carbonitriles. Bioorg. Med. Chem. 2011, 19, 122-133. doi.org/10.1016/ j.bmc.2010.11.040
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 122-133
    • Samadi, A.1    Valderas, C.2    de los Rios, C.3    Bastida, A.4    Chioua, M.5    Gonzalez-Lafuente, L.6    Colmena, I.7    Gandia, L.8    Romero, A.9    del Barrio, L.10    Martin-De-Saavedra, M.D.11    Lopez, M.G.12    Villarroya, M.13    Contelles, J.M.14
  • 40
    • 37349122146 scopus 로고    scopus 로고
    • Multi- Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease
    • Bolognesi, M. L.; Cavalli, A.; Luca Valgimigli, L.; Bartolini, M.; Rosini, M.; Andrisano, V.; Recanatini, M.; Melchiorre, C. Multi- Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease. J. Med. Chem. 2007, 50, 6446-6449.
    • (2007) J. Med. Chem , vol.50 , pp. 6446-6449
    • Bolognesi, M.L.1    Cavalli, A.2    Luca Valgimigli, L.3    Bartolini, M.4    Rosini, M.5    Andrisano, V.6    Recanatini, M.7    Melchiorre, C.8
  • 41
    • 80052567229 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease
    • Chen, S-Y.; Chen, Y.; Li, Y-P.; Chen, S-H.; Tan, J-H.; Ou, T-M.; Gu, L-Q.; Huang, Z-S. Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. Bioorg. Med. Chem. 2011, 19, 5596-5604. doi.org/10.1016/j.bmc.2011.07.033
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 5596-5604
    • Chen, S.-Y.1    Chen, Y.2    Li, Y.-P.3    Chen, S.-H.4    Tan, J.-H.5    Ou, T.-M.6    Gu, L.-Q.7    Huang, Z.-S.8
  • 43
    • 80955136609 scopus 로고    scopus 로고
    • Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation
    • Shan, W-J.; Huang, L.; Zhou, Q.; Meng, F-C.; Li, X-S. Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation. Eur. J. Med. Chem. 2011, 46, 5885-5893. doi:10.1016/j.ejmech. 2011.09.051.
    • (2011) Eur. J. Med. Chem , vol.46 , pp. 5885-5893
    • Shan, W.-J.1    Huang, L.2    Zhou, Q.3    Meng, F.-C.4    Li, X.-S.5
  • 44
    • 80655146741 scopus 로고    scopus 로고
    • Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer's disease
    • Jiang, H.; Wang, X.; Huang, L.; Luo, Z.; Su, T.; Ding, K.; Li, X. Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer's disease. Bioorg. Med. Chem. 2011, 19, 7228-7235. doi:10.1016/j.bmc.2011.09.040
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 7228-7235
    • Jiang, H.1    Wang, X.2    Huang, L.3    Luo, Z.4    Su, T.5    Ding, K.6    Li, X.7
  • 45
    • 77954331097 scopus 로고    scopus 로고
    • Novel Tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties
    • Fernandez-Bachiller, M. I.; Perez, C.; Gonzalez-Munoz, G. C.; Conde, S.; Lopez, M. G.; Villarroya, M.; Garcia, A. G.; Rodriguez- Franco, M. I. Novel Tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties. J. Med. Chem. 2010, 53, 4927-4937. DOI: 10.1021/ jm100329q
    • (2010) J. Med. Chem , vol.53 , pp. 4927-4937
    • Fernandez-Bachiller, M.I.1    Perez, C.2    Gonzalez-Munoz, G.C.3    Conde, S.4    Lopez, M.G.5    Villarroya, M.6    Garcia, A.G.7    Rodriguez-Franco, M.I.8
  • 47
    • 67649996688 scopus 로고    scopus 로고
    • Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action
    • Bolognesi, M. L.; Bartolini, M.; Rosini, M.; Andrisano, V. Melchiorre, C. Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action. Bioorg. Med. Chem. Lett. 2009, 19, 4312-4315. doi.org/ 10.1016/j.bmcl.2009.05.087
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , pp. 4312-4315
    • Bolognesi, M.L.1    Bartolini, M.2    Rosini, M.3    Andrisano, V.4    Melchiorre, C.5
  • 48
    • 57749099247 scopus 로고    scopus 로고
    • Memoquin: A multitarget- directed ligand as an innovative therapeutic opportunity for Alzheimer's disease
    • Bolognesi, M. L.; Cavalli, A.; Melchiorre, C. Memoquin: a multitarget- directed ligand as an innovative therapeutic opportunity for Alzheimer's disease. Neurotherapeutics 2009, 6, 152-162.
    • (2009) Neurotherapeutics , vol.6 , pp. 152-162
    • Bolognesi, M.L.1    Cavalli, A.2    Melchiorre, C.3
  • 49
    • 72249110242 scopus 로고    scopus 로고
    • Toward a rational design of multitarget-directed antioxidants: Merging memoquin and lipoic acid molecular frameworks
    • Bolognesi, M. L.; Cavalli, A.; Bergamini, C.; Fato, R.; Lenaz, G.; Rosini, M.; Bartolini, M.; Andrisano, V.; Melchiorre, C. Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. J. Med. Chem. 2009, 52, 7883-7886. DOI: 10.1021/jm901123n
    • (2009) J. Med. Chem , vol.52 , pp. 7883-7886
    • Bolognesi, M.L.1    Cavalli, A.2    Bergamini, C.3    Fato, R.4    Lenaz, G.5    Rosini, M.6    Bartolini, M.7    Andrisano, V.8    Melchiorre, C.9
  • 50
    • 12144257246 scopus 로고    scopus 로고
    • Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation
    • Bolognesi, M. L.; Andrisano, V.; Bartolini, M.; Banzi, R.; Melchiorre, C. Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. J. Med. Chem. 2005, 48, 24-27. doi.org/10.1021/jm049156q
    • (2005) J. Med. Chem , vol.48 , pp. 24-27
    • Bolognesi, M.L.1    Andrisano, V.2    Bartolini, M.3    Banzi, R.4    Melchiorre, C.5
  • 51
    • 33845327840 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of new 4H-pyrano[2,3- b]quinolone derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals
    • Contelles, J. M.; Leo, R.; Lopez, M. G.; García, A. G.; Villarroya, M. Synthesis and biological evaluation of new 4H-pyrano[2,3- b]quinolone derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals. Eur. J. Med. Chem. 2006, 41, 1464-1469.
    • (2006) Eur. J. Med. Chem , vol.41 , pp. 1464-1469
    • Contelles, J.M.1    Leo, R.2    Lopez, M.G.3    García, A.G.4    Villarroya, M.5
  • 53
    • 42949132291 scopus 로고    scopus 로고
    • Design and synthesis of tacrine-ferulic acid hybrids as multipotent anti-Alzheimer drug candidates
    • Fang, L.; Kraus, B.; Lehmann, J.; Heilmann, J.; Zhang, Y.; Decker, M. Design and synthesis of tacrine-ferulic acid hybrids as multipotent anti-Alzheimer drug candidates. Bioorg. Med. Chem. Lett. 2008, 18, 2905-2909. doi.org/10.1016/j.bmcl.2008.03.073
    • (2008) Bioorg. Med. Chem. Lett , vol.18 , pp. 2905-2909
    • Fang, L.1    Kraus, B.2    Lehmann, J.3    Heilmann, J.4    Zhang, Y.5    Decker, M.6
  • 56
    • 84866739989 scopus 로고    scopus 로고
    • Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease
    • Chao, X.; He, X.; Yang, Y.; Zhou, X.; Jin, M.; Liu, S.; Cheng, Z.; Liu, P.; Wang, Y.; Yu, J.; Tan, Y.; Huang, Y.; Qin, J.; Rapposelli, S.; Pi, R. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. Bioog. Med. Chem. Lett., 2012, 22, 6498-6502. doi.org/10.1016/j.bmcl.2012.08.036
    • (2012) Bioog. Med. Chem. Lett , vol.22 , pp. 6498-6502
    • Chao, X.1    He, X.2    Yang, Y.3    Zhou, X.4    Jin, M.5    Liu, S.6    Cheng, Z.7    Liu, P.8    Wang, Y.9    Yu, J.10    Tan, Y.11    Huang, Y.12    Qin, J.13    Rapposelli, S.14    Pi, R.15
  • 63
    • 80052925179 scopus 로고    scopus 로고
    • Synthesis, biological assessment and molecular modeling of new multipotente MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease
    • Samadi, A.; Chioua, M.; Bolea, I.; de los Rios, C.; Iriepa, I.; Moraleda, I.; Bastida, A.; Esteban, G.; Unzeta, M.; Galvez, E.; Contelles, J. M. Synthesis, biological assessment and molecular modeling of new multipotente MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2011, 46, 4665-4668. doi.org/10.1016/j.ejmech.2011. 05.048
    • (2011) Eur. J. Med. Chem , vol.46 , pp. 4665-4668
    • Samadi, A.1    Chioua, M.2    Bolea, I.3    de los Rios, C.4    Iriepa, I.5    Moraleda, I.6    Bastida, A.7    Esteban, G.8    Unzeta, M.9    Galvez, E.10    Contelles, J.M.11
  • 64
    • 84055217642 scopus 로고    scopus 로고
    • Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop- 2-yn-1-amine Hybrids as New Multipotent Cholinesterase/ Monoamine Oxidase Inhibitors for the Treatment of Alzheimer's Disease
    • Bolea, I.; Jimenez, J. J.; de los Ríos, C.; Chioua, M.; Pouplana, R.; Luque, J.; Unzeta, M.; Contelles, J. M.; Samadi, A. Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop- 2-yn-1-amine Hybrids as New Multipotent Cholinesterase/ Monoamine Oxidase Inhibitors for the Treatment of Alzheimer's Disease. J. Med. Chem. 2011, 54, 8251-8270. doi.org/10.1021/ jm200853t
    • (2011) J. Med. Chem , vol.54 , pp. 8251-8270
    • Bolea, I.1    Jimenez, J.J.2    de los Ríos, C.3    Chioua, M.4    Pouplana, R.5    Luque, J.6    Unzeta, M.7    Contelles, J.M.8    Samadi, A.9
  • 66
    • 84855915652 scopus 로고    scopus 로고
    • Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer's Disease
    • Minarini, A.; Milelli, A.; Tumiatti, V.; Rosini, M.; Simoni, E.; Bolognesi, M.E.; Andrisano, V.; Bartolini, M.; Motori, E.; Angeloni, C.; Hrelia, S. Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer's Disease. Neuropharmacology 2012, 62, 997-1003. doi.org/10.1016/j.neuropharm.2011.10.007
    • (2012) Neuropharmacology , vol.62 , pp. 997-1003
    • Minarini, A.1    Milelli, A.2    Tumiatti, V.3    Rosini, M.4    Simoni, E.5    Bolognesi, M.E.6    Andrisano, V.7    Bartolini, M.8    Motori, E.9    Angeloni, C.10    Hrelia, S.11
  • 67
    • 84880915278 scopus 로고    scopus 로고
    • Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer's Disease
    • Lu, C.; Guo, Y.; Yan, J.; Luo, Z.; Luo, H. B.; Yan, M.; Huang, L.; Li, X. Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer's Disease. J. Med. Chem. 2013, 56, 5843-5859. doi.org/10.1021/jm400567s
    • (2013) J. Med. Chem , vol.56 , pp. 5843-5859
    • Lu, C.1    Guo, Y.2    Yan, J.3    Luo, Z.4    Luo, H.B.5    Yan, M.6    Huang, L.7    Li, X.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.