Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 15, 2013, Pages 4559-4569

  Keri, Rangappa S ^a   Quintanova, Catarina ^a   Marques, Sérgio M ^a   Esteves, A Raquel ^b   Cardoso, Sandra M ^b,c   Santos, M Amélia ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Anti A aggregation; Anti neurodegeneratives; Benzothiazole; Tacrine

Indexed keywords

2 (1,2,3,4 TETRAHYDROACRIDINE 9 YLAMINO)ACETIC ACID; 3 (BENZO[D]THIAZOL 2 YL)PROPAN 1 AMINE; 4 (BENZO[D]THIAZOL 2 YL)ANILINE; 4 (BENZO[D]THIAZOL 2 YLMETHYL)ANILINE; 5 (BENZO[D]THIAZOL 2 YL)PENTAN 1 AMINE; 9 CHLORO 1,2,3,4 TETRAHYDROACRIDINE; [4 (BENZO[D]THIAZOL 2 YL)PHENYL]METHANAMINE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BENZOTHIAZOLE DERIVATIVE; DONEPEZIL; GALANTAMINE; N [3 (BENZO[D]THIAZOL 2 YL)PROPYL] 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANAMIDE; N [4 (BENZO[D]THIAZOL 2 YL)BENZYL] 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANAMIDE; N [4 (BENZO[D]THIAZOL 2 YL)PHENYL] 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANAMIDE; N [4 (BENZO[D]THIAZOL 2 YLMETHYL)PHENYL] 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANAMIDE; N [5 (BENZO[D]THIAZOL 2 YL)PENTYL] 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANAMIDE; RIVASTIGMINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CLINICAL ARTICLE; DRUG ABSORPTION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; HUMAN; IC 50; IN VITRO STUDY; MALE; MOLECULAR MODEL; NERVE CELL NECROSIS; NEUROPROTECTION; PROTEIN AGGREGATION; PROTEIN TARGETING;

EID: 84879689184     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.028     Document Type: Article

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