NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4688-4698

  Chegaev, Konstantin ^a   Federico, Antonella ^a   Marini, Elisabetta ^a   Rolando, Barbara ^a   Fruttero, Roberta ^a   Morbin, Michela ^b   Rossi, Giacomina ^b   Fugnanesi, Valeria ^b   Bastone, Antonio ^c   Salmona, Mario ^c   Badiola, Nahuai B ^d   Gasparini, Laura ^d   Cocco, Sara ^e   Ripoli, Cristian ^e   Grassi, Claudio ^e   Gasco, Alberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

Author keywords

Alzheimer disease; Long term potentiation; Nitric oxide; Tau proteins; Thiacarbocyanines; Amyloid

Indexed keywords

3 ETHYL 2 [3 [3 ETHYL 5 PROPYLOXY 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM IODIDE; 3 ETHYL 2 [3 [3 ETHYL 5 [(3 CARBAMOYLFUROXAN 4 YL)METHOXYL] 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM IODIDE; 3 ETHYL 2 [3 [3 ETHYL 5 [(3 PHENYLFUROXAN 4 YL)OXY] 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM IODIDE; 3 ETHYL 2 [3 [3 ETHYL 5 [(3 PHENYLSULFONYLFUROXAN 4 YL) OXY] 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM IODIDE; 3 ETHYL 2 [3 [3 ETHYL 5 [3 (NITROOXY)PROPYLOXY] 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM IODIDE; 3 ETHYL 5 PROPYLOXY 2 [3 [5 PROPYLOXY 3 ETHYL 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM IODIDE; 3 ETHYL 5 [3 NITROOXYPROPYLOXY] 2 [3 [5 (3 NITROOXY PROPYLOXY) 3 ETHYL 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 1,3 BENZOTHIAZOL 3 IUM TRIFLUOROMETHANESULFONATE; 5 [(3 CARBAMOYLFUROXAN 4 YL)METHOXY] 2 [3 [5 [3 (CARBAMOYLFUROXAN 4 YL)METHOXY] 3 ETHYL 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 3 ETHYL 1,3 BENZOTHIAZOL 3 IUM TRIFLUOROMETHANESULFONATE; 5 [(3CARBAMOYLFUROXAN 4 YL)METHOXY] 2 [3 [5 [3 (CARBAMOYLFUROXAN 4 YL)METHOXY] 3 ETHYL 1,3 BENZOTHIAZOL 2(3H) YLIDENE]PROP 1 EN 1 YL] 3 ETHYL 1,3 BENZOTHIAZOL 3 IUM TRIFLUOROMETHANESULFONATE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CYCLIC GMP; METHYLENE BLUE; NEUROPROTECTIVE AGENT; NITRIC OXIDE DONOR THIACARBOCYANINE DERIVATIVE; NITROPRUSSIDE SODIUM; TAU PROTEIN; UNCLASSIFIED DRUG; CARBOCYANINE; NITRIC OXIDE DONOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTI AGGREGATION ACTIVITY; ARTICLE; BRAIN SLICE; CAPILLARY ENDOTHELIAL CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYNAPTIC INHIBITION;

ALZHEIMER DISEASE; CARBOCYANINES; HUMANS; NITRIC OXIDE DONORS;

EID: 84937813095     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.05.050     Document Type: Article

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