-
1
-
-
0022414054
-
Diagnosis of Alzheimer's disease
-
Khachaturian, Z. S. Diagnosis of Alzheimer's disease. Arch. Neurol. 1985, 42, 1097-1105.
-
(1985)
Arch. Neurol.
, vol.42
, pp. 1097-1105
-
-
Khachaturian, Z.S.1
-
2
-
-
0024595972
-
Synaptic loss in Alzheimer's disease and other dementias
-
Hamos, J. E.; DeGennaro, L. J.; Drachman, D. A. Synaptic loss in Alzheimer's disease and other dementias. Neurology 1989, 39, 355-361.
-
(1989)
Neurology
, vol.39
, pp. 355-361
-
-
Hamos, J.E.1
DeGennaro, L.J.2
Drachman, D.A.3
-
3
-
-
0032105342
-
Cholinergic foundations of Alzheimer's disease therapy
-
Giacobini, E. Cholinergic foundations of Alzheimer's disease therapy. J. Physiol Paris 1998, 92, 283-287.
-
(1998)
J. Physiol Paris
, vol.92
, pp. 283-287
-
-
Giacobini, E.1
-
4
-
-
0025755348
-
Alzheimer disease: Basic and clinical advances
-
Katzman, R.; Jackson, J. E. Alzheimer disease: basic and clinical advances. J. Am. Geriatr. Soc. 1991, 39, 516-525.
-
(1991)
J. Am. Geriatr. Soc.
, vol.39
, pp. 516-525
-
-
Katzman, R.1
Jackson, J.E.2
-
5
-
-
0031038918
-
Alzheimer's disease: Genotypes, phenotypes, and treatments
-
Selkoe, D. J. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 1997, 275, 630-631.
-
(1997)
Science
, vol.275
, pp. 630-631
-
-
Selkoe, D.J.1
-
6
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
Grundke-Iqbal, I.; Iqbal, K.; Quinlan, M.; Tung, Y. C.; Zaidi, M. S.; Wisniewski, H. M. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J. Biol. Chem. 1986, 261, 6084-6089.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
7
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy, J.; Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
8
-
-
0019153066
-
Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts)
-
Glenner, G. G. Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N. Engl. J. Med. 1980, 302, 1283-1292
-
(1980)
N. Engl. J. Med.
, vol.302
, pp. 1283-1292
-
-
Glenner, G.G.1
-
10
-
-
0030841343
-
Conformational disease
-
Carrell, R. W.; Lomas, D. A. Conformational disease. Lancet 1997, 350, 134-138.
-
(1997)
Lancet
, vol.350
, pp. 134-138
-
-
Carrell, R.W.1
Lomas, D.A.2
-
11
-
-
0033200063
-
Protein misfolding, evolution and disease
-
Dobson, C. M. Protein misfolding, evolution and disease. Trends Biochem. Sci. 1999, 24, 329-332.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 329-332
-
-
Dobson, C.M.1
-
12
-
-
0035827318
-
Protein misfolding and disease; protein refolding and therapy
-
Soto, C. Protein misfolding and disease; protein refolding and therapy. FEBS Lett. 2001, 498, 204-207.
-
(2001)
FEBS Lett.
, vol.498
, pp. 204-207
-
-
Soto, C.1
-
13
-
-
0034701238
-
The origins of Alzheimer disease: A is for amyloid
-
Selkoe, D. J. The origins of Alzheimer disease: a is for amyloid. JAMA 2000, 283, 1615-1617.
-
(2000)
JAMA
, vol.283
, pp. 1615-1617
-
-
Selkoe, D.J.1
-
14
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy, J.; Allsop, D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 1991, 12, 383-388.
-
(1991)
Trends Pharmacol. Sci.
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
15
-
-
0032211830
-
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
-
Selkoe, D. J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 1998, 8, 447-453.
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
16
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
Price, D. L.; Sisodia, S. S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 1998, 21, 479-505.
-
(1998)
Annu. Rev. Neurosci.
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
17
-
-
0028945660
-
Evidence that A beta 42 is the real culprit in Alzheimer's disease
-
Younkin, S. G. Evidence that A beta 42 is the real culprit in Alzheimer's disease. Ann. Neurol. 1995, 37, 287-288.
-
(1995)
Ann. Neurol.
, vol.37
, pp. 287-288
-
-
Younkin, S.G.1
-
18
-
-
0033153209
-
Animal models of Alzheimer's disease
-
Higgins, L. S. Animal models of Alzheimer's disease. Mol. Med. Today 1999, 5, 274-276.
-
(1999)
Mol. Med. Today
, vol.5
, pp. 274-276
-
-
Higgins, L.S.1
-
19
-
-
0035477333
-
The cell biology of Alzheimer's disease: Uncovering the secrets of secretases
-
Walter, J.; Kaether, C.; Steiner, H.; Haass, C. The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Curr. Opin. Neurobiol. 2001, 11, 585-590.
-
(2001)
Curr. Opin. Neurobiol.
, vol.11
, pp. 585-590
-
-
Walter, J.1
Kaether, C.2
Steiner, H.3
Haass, C.4
-
20
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
Selkoe, D. J. The molecular pathology of Alzheimer's disease. Neuron 1991, 6, 487-498.
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
21
-
-
0028985799
-
Role of the beta-amyloid protein in Alzheimer's disease
-
Sisodia, S. S.; Price, D. L. Role of the beta-amyloid protein in Alzheimer's disease. FASEB J. 1995, 9, 366-370.
-
(1995)
FASEB J.
, vol.9
, pp. 366-370
-
-
Sisodia, S.S.1
Price, D.L.2
-
22
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A.; Chartier-Harlin, M. C.; Mullan, M.; Brown, J.; Crawford, F.; Fidani, L.; Giuffra, L.; Haynes, A.; Irving, N.; James, L.; Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991, 349, 704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
23
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
Haass, C.; Schlossmacher, M. G.; Hung, A. Y.; Vigo-Pelfrey, C.; Mellon, A.; Ostaszewski, B. L.; Lieberburg, I.; Koo, E. H.; Schenk, D.; Teplow, D. B.; Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 1992, 359, 322-325.
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
-
24
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
-
Seubert, P.; Vigo-Pelfrey, C.; Esch, F.; Lee, M.; Dovey, H.; Davis, D.; Sinha, S.; Schlossmacher, M.; Whaley, J.; Swindlehurst, C.; Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 1992, 359, 325-327.
-
(1992)
Nature
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
Davis, D.6
Sinha, S.7
Schlossmacher, M.8
Whaley, J.9
Swindlehurst, C.10
-
25
-
-
0026760261
-
Production of the Alzheimer amyloid beta protein by normal proteolytic processing
-
Shoji, M.; Golde, T. E.; Ghiso, J.; Cheung, T. T.; Estus, S.; Shaffer, L. M.; Cai, X. D.; McKay, D. M.; Tintner, R.; Frangione, B.; Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 1992, 258, 126-129.
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
Shaffer, L.M.6
Cai, X.D.7
McKay, D.M.8
Tintner, R.9
Frangione, B.10
-
26
-
-
0029916711
-
The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis
-
Soto, C.; Castano, E. M. The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis. Biochem. J. 1996, 314 (Pt 2), 701-707.
-
(1996)
Biochem. J.
, vol.314
, Issue.PART 2
, pp. 701-707
-
-
Soto, C.1
Castano, E.M.2
-
27
-
-
0029895147
-
Brain amyloid - A physicochemical perspective
-
Maggio, J. E.; Mantyh, P. W. Brain amyloid - a physicochemical perspective. Brain Pathol. 1996, 6, 147-162.
-
(1996)
Brain Pathol.
, vol.6
, pp. 147-162
-
-
Maggio, J.E.1
Mantyh, P.W.2
-
28
-
-
0028031486
-
Structural determinants of the Alzheimer's amyloid beta-peptide
-
Soto, C.; Branes, M. C.; Alvarez, J.; Inestrosa, N. C. Structural determinants of the Alzheimer's amyloid beta-peptide. J. Neurochem. 1994, 63, 1191-1198.
-
(1994)
J. Neurochem.
, vol.63
, pp. 1191-1198
-
-
Soto, C.1
Branes, M.C.2
Alvarez, J.3
Inestrosa, N.C.4
-
29
-
-
0032084472
-
Structural and kinetic features of amyloid beta-protein fibrillogenesis
-
Teplow, D. B. Structural and kinetic features of amyloid beta-protein fibrillogenesis. Amyloid. 1998, 5, 121-142.
-
(1998)
Amyloid.
, vol.5
, pp. 121-142
-
-
Teplow, D.B.1
-
30
-
-
0027258525
-
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
Jarrett, J. T.; Berger, E. P.; Lansbury, P. T., Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 1993, 32, 4693-4697.
-
(1993)
Biochemistry
, vol.32
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury Jr., P.T.3
-
31
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki, N.; Cheung, T. T.; Cai, X. D.; Odaka, A.; Otvos, L. Jr.; Eckman, C.; Golde, T. E.; Younkin, S. G. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 1994, 264, 1336-1340.
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
Odaka, A.4
Otvos Jr., L.5
Eckman, C.6
Golde, T.E.7
Younkin, S.G.8
-
32
-
-
0026619343
-
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides
-
Hilbich, C.; Kisters-Woike, B.; Reed, J.; Masters, C. L.; Beyreuther, K. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J. Mol. Biol. 1992, 228, 460-473.
-
(1992)
J. Mol. Biol.
, vol.228
, pp. 460-473
-
-
Hilbich, C.1
Kisters-Woike, B.2
Reed, J.3
Masters, C.L.4
Beyreuther, K.5
-
33
-
-
0028920098
-
Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4
-
Wood, S. J.; Wetzel, R.; Martin, J. D.; Hurle, M. R. Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4. Biochemistry 1995, 34, 724-730.
-
(1995)
Biochemistry
, vol.34
, pp. 724-730
-
-
Wood, S.J.1
Wetzel, R.2
Martin, J.D.3
Hurle, M.R.4
-
34
-
-
0032530466
-
The influence of the central region containing residues 19-25 on the aggregation properties and secondary structure of Alzheimer's beta-amyloid peptide
-
el Agnaf, O. M.; Guthrie, D. J.; Walsh, D. M.; Irvine, G. B. The influence of the central region containing residues 19-25 on the aggregation properties and secondary structure of Alzheimer's beta-amyloid peptide. Eur. J. Biochem. 1998, 256, 560-569.
-
(1998)
Eur. J. Biochem.
, vol.256
, pp. 560-569
-
-
el Agnaf, O.M.1
Guthrie, D.J.2
Walsh, D.M.3
Irvine, G.B.4
-
35
-
-
0028980362
-
The Alpha-Helical to Beta-Strand Transition in the Amino-Terminal Fragment of the Amyloid Beta-Peptide Modulates Amyloid Formation
-
Soto, C.; Castano, E. M.; Frangione, B.; Inestrosa, N. C. The Alpha-Helical to Beta-Strand Transition in the Amino-Terminal Fragment of the Amyloid Beta-Peptide Modulates Amyloid Formation. J. Biol. Chem. 1995, 270, 3063-3067.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 3063-3067
-
-
Soto, C.1
Castano, E.M.2
Frangione, B.3
Inestrosa, N.C.4
-
36
-
-
0029994633
-
Arrest of beta-amyloid fibril formation by a pentapeptide ligand
-
Tjernberg, L. O.; Naslund, J.; Lindqvist, F.; Johansson, J.; Karlstrom, A. R.; Thyberg, J.; Terenius, L.; Nordstedt, C. Arrest of beta-amyloid fibril formation by a pentapeptide ligand. J. Biol. Chem. 1996, 271, 8545-8548.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8545-8548
-
-
Tjernberg, L.O.1
Naslund, J.2
Lindqvist, F.3
Johansson, J.4
Karlstrom, A.R.5
Thyberg, J.6
Terenius, L.7
Nordstedt, C.8
-
37
-
-
0028491608
-
The molecular genetics of Alzheimer's disease
-
Mullan, M.; Crawford, F. The molecular genetics of Alzheimer's disease. Mol. Neurobiol. 1994, 9, 15-22.
-
(1994)
Mol. Neurobiol.
, vol.9
, pp. 15-22
-
-
Mullan, M.1
Crawford, F.2
-
38
-
-
0026682931
-
Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra
-
Barrow, C. J.; Yasuda, A.; Kenny, P. T.; Zagorski, M. G. Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra. J. Mol. Biol. 1992, 225, 1075-1093.
-
(1992)
J. Mol. Biol.
, vol.225
, pp. 1075-1093
-
-
Barrow, C.J.1
Yasuda, A.2
Kenny, P.T.3
Zagorski, M.G.4
-
39
-
-
0033855845
-
The Alzheimer's peptide a beta adopts a collapsed coil structure in water
-
Zhang, S.; Iwata, K.; Lachenmann, M. J.; Peng, J. W.; Li, S.; Stimson, E. R.; Lu, Y.; Felix, A. M.; Maggio, J. E.; Lee, J. P. The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J. Struct. Biol. 2000, 130, 130-141.
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 130-141
-
-
Zhang, S.1
Iwata, K.2
Lachenmann, M.J.3
Peng, J.W.4
Li, S.5
Stimson, E.R.6
Lu, Y.7
Felix, A.M.8
Maggio, J.E.9
Lee, J.P.10
-
40
-
-
0032483035
-
Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?
-
Coles, M.; Bicknell, W.; Watson, A. A.; Fairlie, D. P.; Craik, D. J. Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is? Biochemistty 1998, 37, 11064-11077.
-
(1998)
Biochemistty
, vol.37
, pp. 11064-11077
-
-
Coles, M.1
Bicknell, W.2
Watson, A.A.3
Fairlie, D.P.4
Craik, D.J.5
-
41
-
-
0033555275
-
Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease
-
Shao, H.; Jao, S.; Ma, K.; Zagorski, M. G. Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease. J. Mol. Biol. 1999, 285, 755-773.
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 755-773
-
-
Shao, H.1
Jao, S.2
Ma, K.3
Zagorski, M.G.4
-
42
-
-
0037168655
-
A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR
-
Petkova, A. T.; Ishii, Y.; Balbach, J. J.; Antzutkin, O. N.; Leapman, R. D.; Delaglio, F.; Tycko, R. A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR. Proc. Natl. Acad. Sci. USA 2002, 99, 16742-16747.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Balbach, J.J.3
Antzutkin, O.N.4
Leapman, R.D.5
Delaglio, F.6
Tycko, R.7
-
43
-
-
0035997080
-
Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: Evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance
-
Balbach, J. J.; Petkova, A. T.; Oyler, N. A.; Antzutkin, O. N.; Gordon, D. J.; Meredith, S. C.; Tycko, R. Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance. Biophys. J. 2002, 83, 1205-1216.
-
(2002)
Biophys. J.
, vol.83
, pp. 1205-1216
-
-
Balbach, J.J.1
Petkova, A.T.2
Oyler, N.A.3
Antzutkin, O.N.4
Gordon, D.J.5
Meredith, S.C.6
Tycko, R.7
-
44
-
-
0037168446
-
Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance
-
Antzutkin, O. N.; Leapman, R. D.; Balbach, J. J.; Tycko, R. Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry 2002, 41, 15436-15450.
-
(2002)
Biochemistry
, vol.41
, pp. 15436-15450
-
-
Antzutkin, O.N.1
Leapman, R.D.2
Balbach, J.J.3
Tycko, R.4
-
45
-
-
0344255649
-
Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide
-
Petkova, A. T.; Buntkowsky, G.; Dyda, F.; Leapman, R. D.; Yau, W. M.; Tycko, R. Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide. J. Mol. Biol. 2004, 335, 247-260.
-
(2004)
J. Mol. Biol.
, vol.335
, pp. 247-260
-
-
Petkova, A.T.1
Buntkowsky, G.2
Dyda, F.3
Leapman, R.D.4
Yau, W.M.5
Tycko, R.6
-
46
-
-
0036669881
-
Amyloid-beta oligomers: Their production, toxicity and therapeutic inhibition
-
Walsh, D. M.; Klyubin, I.; Fadeeva, J. V.; Rowan, M. J.; Selkoe, D. J. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem. Soc. Trans. 2002, 30, 552-557.
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 552-557
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Rowan M.J. Selkoe, D.J.4
-
47
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
-
Caughey, B.; Lansbury, P. T. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu. Rev. Neurosci. 2003, 26, 267-298.
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
48
-
-
0037264120
-
Unfolding the role of Protein Misfolding in Neurodegenerative Diseases
-
Soto, C. Unfolding the role of Protein Misfolding in Neurodegenerative Diseases. Nature Rev. Neurosci. 2003, 4, 49-60.
-
(2003)
Nature Rev. Neurosci.
, vol.4
, pp. 49-60
-
-
Soto, C.1
-
49
-
-
0030908095
-
Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins
-
Harper, J. D.; Lansbury, P. T. Jr. Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu. Rev. Biochem. 1997, 66, 385-407.
-
(1997)
Annu. Rev. Biochem.
, vol.66
, pp. 385-407
-
-
Harper, J.D.1
Lansbury Jr., P.T.2
-
50
-
-
0028227756
-
Nucleation of amyloidogenesis in infectious and noninfectious amyloidoses of brain
-
Gajdusek, D. C. Nucleation of amyloidogenesis in infectious and noninfectious amyloidoses of brain. Ann. N. Y. Acad. Sci. 1994, 724, 173-190.
-
(1994)
Ann. N. Y. Acad. Sci.
, vol.724
, pp. 173-190
-
-
Gajdusek, D.C.1
-
51
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
Jarrett, J. T.; Lansbury, P. T., Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 1993, 73, 1055-1058.
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury Jr., P.T.2
-
52
-
-
3042675121
-
Observation of sequence specificity in the seeding of protein amyloid fibrils
-
Krebs, M. R.; Morozova-Roche, L. A.; Daniel, K.; Robinson, C. V.; Dobson, C. M. Observation of sequence specificity in the seeding of protein amyloid fibrils. Protein Sci. 2004, 13, 1933-1938.
-
(2004)
Protein Sci.
, vol.13
, pp. 1933-1938
-
-
Krebs, M.R.1
Morozova-Roche, L.A.2
Daniel, K.3
Robinson, C.V.4
Dobson, C.M.5
-
53
-
-
2342444028
-
Seeding specificity in amyloid growth induced by heterologous fibrils
-
O'Nuallain, B.; Williams, A. D.; Westermark, P.; Wetzel, R. Seeding specificity in amyloid growth induced by heterologous fibrils. J. Biol. Chem. 2004, 279, 17490-17499.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 17490-17499
-
-
O'Nuallain, B.1
Williams, A.D.2
Westermark, P.3
Wetzel, R.4
-
54
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abetal 42 are potent central nervous system neurotoxins
-
Lambert, M. P.; Barlow, A. K.; Chromy, B. A.; Edwards, C.; Freed, R.; Liosatos, M.; Morgan, T. E.; Rozovsky, I.; Trommer, B.; Viola, K. L.; Wals, P.; Zhang, C.; Finch, C. E.; Krafft, G. A.; Klein, W. L. Diffusible, nonfibrillar ligands derived from Abetal 42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. (USA) 1998, 95, 6448-6453.
-
(1998)
Proc. Natl. Acad. Sci. (USA)
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
55
-
-
2542427690
-
Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration
-
Walsh, D. M.; Selkoe, D. J. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett. 2004, 11, 213-228.
-
(2004)
Protein Pept Lett.
, vol.11
, pp. 213-228
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
56
-
-
0034869176
-
Protofibrils, the unifying toxic molecule of neurodegenerative disorders?
-
Haass, C.; Steiner, H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders? Nat. Neurosci. 2001, 4, 859-860.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 859-860
-
-
Haass, C.1
Steiner, H.2
-
57
-
-
0030799122
-
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh, D. M.; Lomakin, A.; Benedek, G. B.; Condron, M. M.; Teplow, D. B. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J. Biol. Chem. 1997, 272, 22364-22372.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
Lomakin, A.2
Benedek, G.B.3
Condron, M.M.4
Teplow, D.B.5
-
58
-
-
0030614627
-
Observation of metastable Abets amyloid protofibrils by atomic force microscopy
-
Harper, J. D.; Wong, S. S.; Lieber, C. M.; Lansbury, P. T. Observation of metastable Abets amyloid protofibrils by atomic force microscopy. Chem. Biol. 1997, 4, 119-125.
-
(1997)
Chem. Biol.
, vol.4
, pp. 119-125
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury, P.T.4
-
59
-
-
0033520461
-
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates
-
Walsh, D. M.; Hartley, D. M.; Kusumoto, Y.; Fezoui, Y.; Condron, M. M.; Lomakin, A.; Benedek, G. B.; Selkoe, D. J.; Teplow, D. B. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J. Biol. Chem. 1999, 274, 25945-25952.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25945-25952
-
-
Walsh, D.M.1
Hartley, D.M.2
Kusumoto, Y.3
Fezoui, Y.4
Condron, M.M.5
Lomakin, A.6
Benedek, G.B.7
Selkoe, D.J.8
Teplow, D.B.9
-
60
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
-
Lorenzo, A.; Yankner, B. A. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc. Natl. Acad. Sci. U S. A 1994, 91, 12243-12247.
-
(1994)
Proc. Natl. Acad. Sci. U S. A
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
61
-
-
0027447286
-
Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
-
Pike, C. J.; Burdick, D.; Walencewicz, A. J.; Glabe, C. G.; Cotman, C. W. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 1993, 13, 1676-1687.
-
(1993)
J. Neurosci.
, vol.13
, pp. 1676-1687
-
-
Pike, C.J.1
Burdick, D.2
Walencewicz, A.J.3
Glabe, C.G.4
Cotman, C.W.5
-
62
-
-
0024350203
-
Beta-amyloid deposition and paired helical filament formation: Which histopathological feature is more significant in Alzheimer's disease?
-
Dickson, D. W.; Yen, S. H. Beta-amyloid deposition and paired helical filament formation: which histopathological feature is more significant in Alzheimer's disease? Neurobiol. Aging 1989, 10, 402-404.
-
(1989)
Neurobiol. Aging
, vol.10
, pp. 402-404
-
-
Dickson, D.W.1
Yen, S.H.2
-
63
-
-
0031033838
-
The pathology of Alzheimer's disease: Numbers count
-
Terry, R. D. The pathology of Alzheimer's disease: numbers count. Ann. Neurol. 1997, 41, 7.
-
(1997)
Ann. Neurol.
, vol.41
, pp. 7
-
-
Terry, R.D.1
-
64
-
-
0032839878
-
Plaque busters: Strategies to inhibit amyloid formation in Alzheimers disease
-
Soto, C. Plaque busters: strategies to inhibit amyloid formation in Alzheimers disease. Mol. Med. Today 1999, 5, 343-350.
-
(1999)
Mol. Med. Today
, vol.5
, pp. 343-350
-
-
Soto, C.1
-
65
-
-
0029664613
-
Selective inhibition of Abeta fibril formation
-
Wood, S. J.; MacKenzie, L.; Maleeff, B.; Hurle, M. R; Wetzel, R. Selective inhibition of Abeta fibril formation. J. Biol. Chem. 1996, 271, 4086-4092.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4086-4092
-
-
Wood, S.J.1
MacKenzie, L.2
Maleeff, B.3
Hurle, M.R.4
Wetzel, R.5
-
66
-
-
0032137189
-
Fibrillogenesis of beta-amyloid
-
Allsop, D.; Howlett, D.; Christie, G.; Karran, E. Fibrillogenesis of beta-amyloid. Biochem. Soc. Trans. 1998, 26, 459-463.
-
(1998)
Biochem. Soc. Trans.
, vol.26
, pp. 459-463
-
-
Allsop, D.1
Howlett, D.2
Christie, G.3
Karran, E.4
-
67
-
-
0028913416
-
Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: Implications for Alzheime'r disease
-
Kisilevsky, R.; Lemieux, L. J.; Fraser, P. E.; Kong, X.; Hultin, P. G.; Szarek, W. A. Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheime'r disease. Nat. Med. 1995, 1, 143-148.
-
(1995)
Nat. Med.
, vol.1
, pp. 143-148
-
-
Kisilevsky, R.1
Lemieux, L.J.2
Fraser, P.E.3
Kong, X.4
Hultin, P.G.5
Szarek, W.A.6
-
68
-
-
25144471718
-
Inhibition of amyloid fibril formation of beta-amyloid peptides via the amphiphilic surfactants
-
Wang, S. S.; Chen, Y. T.; Chou, S. W. Inhibition of amyloid fibril formation of beta-amyloid peptides via the amphiphilic surfactants. Biochim. Biophys. Acta 2005, 1741, 307-313.
-
(2005)
Biochim. Biophys. Acta
, vol.1741
, pp. 307-313
-
-
Wang, S.S.1
Chen, Y.T.2
Chou, S.W.3
-
69
-
-
0141642253
-
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease
-
Ono, K.; Yoshiike, Y.; Takashima, A.; Hasegawa, K.; Naiki, H.; Yamada, M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J. Neurochem. 2003, 87, 172-181.
-
(2003)
J. Neurochem.
, vol.87
, pp. 172-181
-
-
Ono, K.1
Yoshiike, Y.2
Takashima, A.3
Hasegawa, K.4
Naiki, H.5
Yamada, M.6
-
70
-
-
7044286419
-
Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro
-
Ono, K.; Hasegawa, K.; Naiki, H.; Yamada, M. Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. Biochim. Biophys. Acta 2004, 1690, 193-202.
-
(2004)
Biochim. Biophys. Acta
, vol.1690
, pp. 193-202
-
-
Ono, K.1
Hasegawa, K.2
Naiki, H.3
Yamada, M.4
-
71
-
-
1542364225
-
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
-
Ono, K.; Hasegawa, K.; Naiki, H.; Yamada, M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J. Neurosci. Res. 2004, 75, 742-750.
-
(2004)
J. Neurosci. Res.
, vol.75
, pp. 742-750
-
-
Ono, K.1
Hasegawa, K.2
Naiki, H.3
Yamada, M.4
-
72
-
-
24044483249
-
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42
-
Liu, R.; Barkhordarian, H.; Emadi, S.; Park, C. B.; Sierks, M. R. Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. Neurobiol Dis. 2005, 20, 74-81.
-
(2005)
Neurobiol Dis.
, vol.20
, pp. 74-81
-
-
Liu, R.1
Barkhordarian, H.2
Emadi, S.3
Park, C.B.4
Sierks, M.R.5
-
73
-
-
0026793767
-
Neurofibrillary Tangles and Senile Plaques in Brain of Elderly Leprosy Patients
-
Namba, Y.; Kawatsu, K.; Izumi, S.; Ueki, A.; Ikeda, K. Neurofibrillary Tangles and Senile Plaques in Brain of Elderly Leprosy Patients. Lancet 1992, 340, 978.
-
(1992)
Lancet
, vol.340
, pp. 978
-
-
Namba, Y.1
Kawatsu, K.2
Izumi, S.3
Ueki, A.4
Ikeda, K.5
-
74
-
-
0029863551
-
Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible funcfion as a hydroxyl radical scavenger
-
Tomiyama, T.; Shoji, A.; Kataoka, K.; Suwa, Y.; Asano, S.; Kaneko, H.; Endo, N. Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible funcfion as a hydroxyl radical scavenger. J. Biol. Chem. 1996, 271, 6839-6844.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6839-6844
-
-
Tomiyama, T.1
Shoji, A.2
Kataoka, K.3
Suwa, Y.4
Asano, S.5
Kaneko, H.6
Endo, N.7
-
75
-
-
0032571381
-
Inhibition of Alzheimer beta-fibrillogenesis by melatonin
-
Pappolla, M.; Bozner, P.; Soto, C.; Shao, H.; Robakis, N. K.; Zagorski, M.; Frangione, B.; Ghiso, J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J. Biol. Chem. 1998, 273, 7185-7188.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7185-7188
-
-
Pappolla, M.1
Bozner, P.2
Soto, C.3
Shao, H.4
Robakis, N.K.5
Zagorski, M.6
Frangione, B.7
Ghiso, J.8
-
76
-
-
0029956783
-
Nicotine inhibits amyloid formation by the beta-peptide
-
Salomon, A. R.; Marcinowski, K. J.; Friedland, R. P.; Zagorski, M. G. Nicotine inhibits amyloid formation by the beta-peptide. Biochemistry 1996, 35, 13568-13578.
-
(1996)
Biochemistry
, vol.35
, pp. 13568-13578
-
-
Salomon, A.R.1
Marcinowski, K.J.2
Friedland, R.P.3
Zagorski, M.G.4
-
77
-
-
0031576349
-
Estrogen blocks neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells
-
Mook-Jung, I.; Joo, I.; Sohn, S.; Kwon, H. J.; Huh, K.; Jung, M. W. Estrogen blocks neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells. Neurosci. Lett. 1997, 235, 101-104.
-
(1997)
Neurosci. Lett.
, vol.235
, pp. 101-104
-
-
Mook-Jung, I.1
Joo, I.2
Sohn, S.3
Kwon, H.J.4
Huh, K.5
Jung, M.W.6
-
78
-
-
0028914019
-
Interaction of the anthracycline 4′-iodo-4′-deoxydoxorubicin with amyloid fibrils: Inhibition of amyloidogenesis
-
Merlini, G.; Ascari, E.; Amboldi, N.; Bellotti, V.; Arbustini, E.; Perfetti, V.; Ferrari, M.; Zorzoli, I.; Marinone, M. G.; Garini, P.; Interaction of the anthracycline 4′-iodo-4′-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis. Proc. Natl. Acad, Sci. U. S. A 1995, 92, 2959-2963.
-
(1995)
Proc. Natl. Acad, Sci. U. S. A
, vol.92
, pp. 2959-2963
-
-
Merlini, G.1
Ascari, E.2
Amboldi, N.3
Bellotti, V.4
Arbustini, E.5
Perfetti, V.6
Ferrari, M.7
Zorzoli, I.8
Marinone, M.G.9
Garini, P.10
-
79
-
-
0029910347
-
A strategy for designing inhibitors of beta-amyloid toxicity
-
Ghanta, J.; Shen, C. L.; Kiessling, L. L.; Murphy, R. M. A strategy for designing inhibitors of beta-amyloid toxicity. J. Biol. Chem. 1996, 271, 29525-29528.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 29525-29528
-
-
Ghanta, J.1
Shen, C.L.2
Kiessling, L.L.3
Murphy, R.M.4
-
80
-
-
0033596944
-
Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity
-
Pallitto, M. M.; Ghanta, J.; Heinzelman, P.; Kiessling, L. L.; Murphy, R. M. Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity. Biochemistry 1999, 38, 3570-3578.
-
(1999)
Biochemistry
, vol.38
, pp. 3570-3578
-
-
Pallitto, M.M.1
Ghanta, J.2
Heinzelman, P.3
Kiessling, L.L.4
Murphy, R.M.5
-
81
-
-
0032866410
-
Design and testing of inhibitors of fibril formation
-
Findeis, M. A.; Molineaux, S. M. Design and testing of inhibitors of fibril formation. Methods Enzymol. 1999, 309, 476-488.
-
(1999)
Methods Enzymol.
, vol.309
, pp. 476-488
-
-
Findeis, M.A.1
Molineaux, S.M.2
-
82
-
-
0033603003
-
Modified-peptide inhibitors of amyloid beta-peptide polymerization
-
Findeis, M. A.; Musso, G. M.; Arico-Muendel, C. C.; Benjamin, H. W.; Hundal, A. M.; Lee, J. J.; Chin, J.; Kelley, M.; Wakefield, J.; Hayward, N. J.; Molineaux, S. M. Modified-peptide inhibitors of amyloid beta-peptide polymerization. Biochemistry 1999, 38, 6791-6800.
-
(1999)
Biochemistry
, vol.38
, pp. 6791-6800
-
-
Findeis, M.A.1
Musso, G.M.2
Arico-Muendel, C.C.3
Benjamin, H.W.4
Hundal, A.M.5
Lee, J.J.6
Chin, J.7
Kelley, M.8
Wakefield, J.9
Hayward, N.J.10
Molineaux, S.M.11
-
83
-
-
0035676280
-
Characterization of cholyl-leu-val-phe-phe-ala-OH as an inhibitor of amyloid beta-peptide polymerization
-
Findeis, M. A.; Lee, J. J.; Kelley, M.; Wakefield, J. D.; Zhang, M. H.; Chin, J.; Kubasek, W.; Molineaux, S. M. Characterization of cholyl-leu-val-phe-phe-ala-OH as an inhibitor of amyloid beta-peptide polymerization. Amyloid. 2001, 8, 231-241.
-
(2001)
Amyloid.
, vol.8
, pp. 231-241
-
-
Findeis, M.A.1
Lee, J.J.2
Kelley, M.3
Wakefield, J.D.4
Zhang, M.H.5
Chin, J.6
Kubasek, W.7
Molineaux, S.M.8
-
84
-
-
0034682788
-
Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: A general strategy to prevent amyloid formation
-
Hughes, E.; Burke, R. M.; Doig, A. J. Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation. J. Biol. Chem. 2000, 275, 25109-25115.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25109-25115
-
-
Hughes, E.1
Burke, R.M.2
Doig, A.J.3
-
85
-
-
0036095659
-
Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abetal-40 fibrillogenesis
-
Gordon, D. J.; Tappe, R.; Meredith, S. C. Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abetal-40 fibrillogenesis. J. Pept. Res. 2002, 60, 37-55.
-
(2002)
J. Pept. Res.
, vol.60
, pp. 37-55
-
-
Gordon, D.J.1
Tappe, R.2
Meredith, S.C.3
-
86
-
-
0037457928
-
Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions
-
Gordon, D. J.; Meredith S. C. Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions. Biochemistry 2003, 42, 475-485.
-
(2003)
Biochemistry
, vol.42
, pp. 475-485
-
-
Gordon, D.J.1
Meredith, S.C.2
-
87
-
-
0036669897
-
Inhibition of toxicity and protofibril formation in the amyloid-beta peptide beta(25-35) using N-methylated derivatives
-
Doig, A. J.; Hughes, E.; Burke, R. M.; Su, T. J.; Heenan, R. K.; Lu, J. Inhibition of toxicity and protofibril formation in the amyloid-beta peptide beta(25-35) using N-methylated derivatives. Biochem. Soc. Trans. 2002, 30, 537-542.
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 537-542
-
-
Doig, A.J.1
Hughes, E.2
Burke, R.M.3
Su, T.J.4
Heenan, R.K.5
Lu, J.6
-
88
-
-
0036257686
-
Converting a peptide into a drug: Strategies to improve stability and bioavailability
-
Adessi, C.; Soto, C. Converting a peptide into a drug: strategies to improve stability and bioavailability. Curr. Med. Chem. 2002, 9, 963-978.
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 963-978
-
-
Adessi, C.1
Soto, C.2
-
89
-
-
0031445940
-
Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: Relation to Alzheimer's disease
-
Blanchard, B. J.; Konopka, G.; Russell, M.; Ingram, V. M. Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease. Brain Res. 1997, 776, 40-50.
-
(1997)
Brain Res.
, vol.776
, pp. 40-50
-
-
Blanchard, B.J.1
Konopka, G.2
Russell, M.3
Ingram, V.M.4
-
90
-
-
0033788536
-
Elimination of Amyloid beta Neurotoxicity
-
Blanchard, B. J.; Hiniker, A. E.; Lu, C. C.; Margolin, Y.; Yu, A. S.; Ingram, V. M. Elimination of Amyloid beta Neurotoxicity. J. Alzheimers. Dis. 2000, 2, 137-149.
-
(2000)
J. Alzheimers. Dis.
, vol.2
, pp. 137-149
-
-
Blanchard, B.J.1
Hiniker, A.E.2
Lu, C.C.3
Margolin, Y.4
Yu, A.S.5
Ingram, V.M.6
-
91
-
-
0030600371
-
Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation
-
Soto, C.; Kindy, M. S.; Baumann, M.; Frangione, B. Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation. Biochem. Biophys. Res. Commun. 1996, 226, 672-680.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.226
, pp. 672-680
-
-
Soto, C.1
Kindy, M.S.2
Baumann, M.3
Frangione, B.4
-
92
-
-
0031873102
-
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
-
Soto, C.; Sigurdsson, E. M.; Morelli, L.; Kumar, R. A.; Castano, E. M.; Frangione, B. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat. Med. 1998, 4, 822-826.
-
(1998)
Nat. Med.
, vol.4
, pp. 822-826
-
-
Soto, C.1
Sigurdsson, E.M.2
Morelli, L.3
Kumar, R.A.4
Castano, E.M.5
Frangione, B.6
-
93
-
-
0033973529
-
In vivo reversal of amyloid-beta lesions in rat brain
-
Sigurdsson, E. M.; Permanne, B.; Soto, C.; Wisniewski, T.; Frangione, B. In vivo reversal of amyloid-beta lesions in rat brain. J. Neuropathol. Exp. Neurol. 2000, 59, 11-17.
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 11-17
-
-
Sigurdsson, E.M.1
Permanne, B.2
Soto, C.3
Wisniewski, T.4
Frangione, B.5
-
94
-
-
0036050867
-
Are beta-sheet breaker peptides dissolving the therapeutic problem of Alzheimer's disease?
-
Permanne, B.; Adessi, C.; Fraga, S.; Frossard, M. J.; Saborio, G. P.; Soto, C. Are beta-sheet breaker peptides dissolving the therapeutic problem of Alzheimer's disease? J. Neural Transm. Suppl 2002, 293-301.
-
(2002)
J. Neural Transm. Suppl
, pp. 293-301
-
-
Permanne, B.1
Adessi, C.2
Fraga, S.3
Frossard, M.J.4
Saborio, G.P.5
Soto, C.6
-
95
-
-
0036615884
-
Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide
-
Permanne, B.; Adessi, C.; Saborio, G. P.; Fraga, S.; Frossard, M. J.; Van Dorpe, J.; Dewachter, I.; Banks, W. A.; Van Leuven, F.; Soto, C. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J. 2002, 16, 860-862.
-
(2002)
FASEB J.
, vol.16
, pp. 860-862
-
-
Permanne, B.1
Adessi, C.2
Saborio, G.P.3
Fraga, S.4
Frossard, M.J.5
Van Dorpe, J.6
Dewachter, I.7
Banks, W.A.8
Van Leuven, F.9
Soto, C.10
-
96
-
-
6044240725
-
β-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits
-
Chacon, M. A.; Barria, M. I.; Soto, C.; Inestrosa, N. C. β-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits. Mol. Psychiatry 2004, 9, 953-961.
-
(2004)
Mol. Psychiatry
, vol.9
, pp. 953-961
-
-
Chacon, M.A.1
Barria, M.I.2
Soto, C.3
Inestrosa, N.C.4
-
97
-
-
0028872558
-
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
-
Evans, K. C.; Berger, E. P.; Cho, C. G.; Weisgraber, K. H.; Lansbury, P. T., Jr. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proc. Natl. Acad. Sci. USA 1995, 92, 763-767.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 763-767
-
-
Evans, K.C.1
Berger, E.P.2
Cho, C.G.3
Weisgraber, K.H.4
Lansbury Jr., P.T.5
-
98
-
-
0030014990
-
Apolipoprotein J and Alzheimer's amyloid beta solubility
-
Matsubara, E.; Soto, C.; Governale, S.; Frangione, B.; Ghiso, J. Apolipoprotein J and Alzheimer's amyloid beta solubility. Biochem. J. 1996, 316 (Pt 2), 671-679.
-
(1996)
Biochem. J.
, vol.316
, Issue.PART 2
, pp. 671-679
-
-
Matsubara, E.1
Soto, C.2
Governale, S.3
Frangione, B.4
Ghiso, J.5
-
99
-
-
0027999030
-
Transthyretin sequesters amyloid beta protein and prevents amyloid formation
-
Schwarzman, A. L.; Gregori, L.; Vitek, M. P.; Lyubski, S.; Strittmatter, W. J.; Enghilde, J. J.; Bhasin, R.; Silverman, J.; Weisgraber, K. H.; Coyle, P. K.; Transthyretin sequesters amyloid beta protein and prevents amyloid formation, Proc. Natl. Acad. Sci. USA 1994, 91, 8368-8372.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8368-8372
-
-
Schwarzman, A.L.1
Gregori, L.2
Vitek, M.P.3
Lyubski, S.4
Strittmatter, W.J.5
Enghilde, J.J.6
Bhasin, R.7
Silverman, J.8
Weisgraber, K.H.9
Coyle, P.K.10
-
100
-
-
0028802246
-
Inhibition of Alzheimer beta-peptide fibril formation by serum amyloid P component
-
Janciauskiene, S.; Garcia, D. F.; Carlemalm, E.; Dahlback, B.; Eriksson, S. Inhibition of Alzheimer beta-peptide fibril formation by serum amyloid P component. J. Biol. Chem. 1995, 270, 26041-26044.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26041-26044
-
-
Janciauskiene, S.1
Garcia, D.F.2
Carlemalm, E.3
Dahlback, B.4
Eriksson, S.5
-
101
-
-
0032561313
-
Alzheimer's peptide Abetal-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate
-
Janciauskiene, S.; Rubin, H.; Lukacs, C. M.; Wright, H. T. Alzheimer's peptide Abetal-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate. J. Biol. Chem. 1998, 273, 28360-28364.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 28360-28364
-
-
Janciauskiene, S.1
Rubin, H.2
Lukacs, C.M.3
Wright, H.T.4
-
102
-
-
0034332511
-
Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain
-
Castillo, G. M.; Lukito, W.; Peskind, E.; Raskind, M.; Kirschner, D. A.; Yee, A. G.; Snow, A. D. Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain. J. Neurosci. Res. 2000, 62, 451-462.
-
(2000)
J. Neurosci. Res.
, vol.62
, pp. 451-462
-
-
Castillo, G.M.1
Lukito, W.2
Peskind, E.3
Raskind, M.4
Kirschner, D.A.5
Yee, A.G.6
Snow, A.D.7
-
103
-
-
0030575944
-
Laminin inhibits amyloid-beta-peptide fibrillation
-
Bronfman, F. C.; Garrido, J.; Alvarez, A.; Morgan, C.; Inestrosa, N. C. Laminin inhibits amyloid-beta-peptide fibrillation. Neurosci. Lett. 1996, 218, 201-203.
-
(1996)
Neurosci. Lett.
, vol.218
, pp. 201-203
-
-
Bronfman, F.C.1
Garrido, J.2
Alvarez, A.3
Morgan, C.4
Inestrosa, N.C.5
-
104
-
-
0028986408
-
Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E
-
Castano, E. M.; Prelli, F.; Wisniewski, T.; Golabek, A.; Kumar, R. A.; Soto, C.; Frangione, B. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. Biochem. J. 1995, 306 (Pt 2), 599-604.
-
(1995)
Biochem. J.
, vol.306
, Issue.PART 2
, pp. 599-604
-
-
Castano, E.M.1
Prelli, F.2
Wisniewski, T.3
Golabek, A.4
Kumar, R.A.5
Soto, C.6
Frangione, B.7
-
105
-
-
0028173205
-
Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
-
Ma, J.; Yee, A.; Brewer, H. B., Jr.; Das, S.; Potter, H. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 1994, 372, 92-94.
-
(1994)
Nature
, vol.372
, pp. 92-94
-
-
Ma, J.1
Yee, A.2
Brewer Jr., H.B.3
Das, S.4
Potter, H.5
-
106
-
-
0029075189
-
Amyloid P component promotes aggregation of Alzheimer's beta-amyloid peptide
-
Hamazaki, H. Amyloid P component promotes aggregation of Alzheimer's beta-amyloid peptide. Biochem. Biophys. Res. Commun. 1995, 211, 349-353.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.211
, pp. 349-353
-
-
Hamazaki, H.1
-
107
-
-
0028350298
-
The role of apolipoprotein E in the nervous system
-
Weisgraber, K. H.; Roses, A. D.; Strittmatter, W. J. The role of apolipoprotein E in the nervous system. Curr. Opin. Lipidol. 1994, 5, 110-116.
-
(1994)
Curr. Opin. Lipidol.
, vol.5
, pp. 110-116
-
-
Weisgraber, K.H.1
Roses, A.D.2
Strittmatter, W.J.3
-
108
-
-
0030005627
-
Apolipoprotein E alleles as risk factors in Alzheimer's disease
-
Roses, A. D. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu. Rev. Med. 1996, 47, 387-400.
-
(1996)
Annu. Rev. Med.
, vol.47
, pp. 387-400
-
-
Roses, A.D.1
-
109
-
-
0032875656
-
Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions
-
Ohm, T. G.; Scharnagl, H.; Marz, W.; Bohl, J. Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions. Acta Neuropathol. (Berl) 1999, 98, 273-280.
-
(1999)
Acta Neuropathol. (Berl)
, vol.98
, pp. 273-280
-
-
Ohm, T.G.1
Scharnagl, H.2
Marz, W.3
Bohl, J.4
-
110
-
-
0345072821
-
Apolipoprotein E, amyloid, and Alzheimer disease
-
339
-
Bales, K. R.; Dodart, J. C.; DeMattos, R. B.; Holtzman, D. M.; Paul, S. M. Apolipoprotein E, amyloid, and Alzheimer disease. Mol. Interv. 2002, 2, 363-75, 339.
-
(2002)
Mol. Interv.
, vol.2
, pp. 363-375
-
-
Bales, K.R.1
Dodart, J.C.2
DeMattos, R.B.3
Holtzman, D.M.4
Paul, S.M.5
-
111
-
-
0030005454
-
Expression of apolipoprotein E inhibits aggregation of the C-terminal fragments of beta-amyloid precursor protein
-
Ohman, T.; Dang, N.; LeBoeuf, R. C.; Furlong, C. E.; Fukuchi, K. Expression of apolipoprotein E inhibits aggregation of the C-terminal fragments of beta-amyloid precursor protein. Neurosci. Lett. 1996, 210, 65-68.
-
(1996)
Neurosci. Lett.
, vol.210
, pp. 65-68
-
-
Ohman, T.1
Dang, N.2
LeBoeuf, R.C.3
Furlong, C.E.4
Fukuchi, K.5
-
112
-
-
0028806980
-
Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's beta-amyloid peptide in cultured vascular smooth muscle cells
-
Mazur-Kolecka, B.; Frackowiak, J.; Wisniewski, H. M. Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's beta-amyloid peptide in cultured vascular smooth muscle cells. Brain Res. 1995, 698, 217-222.
-
(1995)
Brain Res.
, vol.698
, pp. 217-222
-
-
Mazur-Kolecka, B.1
Frackowiak, J.2
Wisniewski, H.M.3
-
113
-
-
0028985574
-
Alzheimer-type neuropathology in trunsgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games, D.; Adams, D.; Alessandrini, R.; Barbour, R.; Berthelette, P.; Blackwell, C.; Carr, T.; Clemens, J.; Donaldson, T.; Gillespie, F. Alzheimer-type neuropathology in trunsgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 1995, 373, 523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
Carr, T.7
Clemens, J.8
Donaldson, T.9
Gillespie, F.10
-
114
-
-
12844273475
-
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease
-
Dodart, J. C.; Marr, R. A.; Koistinaho, M.; Gregersen, B. M.; Malkani, S.; Verma, I. M.; Paul, S. M. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2005, 102, 1211-1216.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1211-1216
-
-
Dodart, J.C.1
Marr, R.A.2
Koistinaho, M.3
Gregersen, B.M.4
Malkani, S.5
Verma, I.M.6
Paul, S.M.7
-
115
-
-
0033869207
-
Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E
-
Golabek, A. A.; Kida, E.; Walus, M.; Perez, C.; Wisniewski, T.; Soto, C. Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophys. J. 2000, 79, 1008-1015.
-
(2000)
Biophys. J.
, vol.79
, pp. 1008-1015
-
-
Golabek, A.A.1
Kida, E.2
Walus, M.3
Perez, C.4
Wisniewski, T.5
Soto, C.6
-
116
-
-
4344659648
-
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice
-
Sadowski, M.; Pankiewicz, J.; Scholtzova, H.; Ripellino, J. A.; Li, Y.; Schmidt, S. D.; Mathews, P. M.; Fryer, J. D.; Holtzman, D. M.; Sigurdsson, E. M.; Wisniewski, T. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am. J. Pathol. 2004, 165, 937-948.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 937-948
-
-
Sadowski, M.1
Pankiewicz, J.2
Scholtzova, H.3
Ripellino, J.A.4
Li, Y.5
Schmidt, S.D.6
Mathews, P.M.7
Fryer, J.D.8
Holtzman, D.M.9
Sigurdsson, E.M.10
Wisniewski, T.11
-
117
-
-
0024442081
-
Altered gene expression in Alzheimer's disease brain tissue
-
May, P. C.; Johnson, S. A.; Poirier, J.; Lampert-Etchells, M.; Finch, C. E. Altered gene expression in Alzheimer's disease brain tissue. Can. J. Neurol. Sci. 1989, 16, 473-476.
-
(1989)
Can. J. Neurol. Sci.
, vol.16
, pp. 473-476
-
-
May, P.C.1
Johnson, S.A.2
Poirier, J.3
Lampert-Etchells, M.4
Finch, C.E.5
-
118
-
-
0026567452
-
SP-40,40 is a constituent of Alzheimer's amyloid
-
Choi-Miura, N. H.; Ihara, Y.; Fukuchi, K.; Takeda, M.; Nakano, Y.; Tobe, T.; Tomita, M. SP-40,40 is a constituent of Alzheimer's amyloid. Acta Neuropathol. (Berl) 1992, 83, 260-264.
-
(1992)
Acta Neuropathol. (Berl)
, vol.83
, pp. 260-264
-
-
Choi-Miura, N.H.1
Ihara, Y.2
Fukuchi, K.3
Takeda, M.4
Nakano, Y.5
Tobe, T.6
Tomita, M.7
-
119
-
-
0028927946
-
Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain
-
Kida, E.; Pluta, R.; Lossinsky, A. S.; Golabek, A. A.; Choi-Miura, N. H.; Wisniewski, H. M.; Mossakowski, M. J. Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain. Brain Res. 1995, 674, 341-346.
-
(1995)
Brain Res.
, vol.674
, pp. 341-346
-
-
Kida, E.1
Pluta, R.2
Lossinsky, A.S.3
Golabek, A.A.4
Choi-Miura, N.H.5
Wisniewski, H.M.6
Mossakowski, M.J.7
-
120
-
-
0026537880
-
Distribution of clusterin in Alzheimer brain tissue
-
McGeer, P. L.; Kawamata, T.; Walker, D. G. Distribution of clusterin in Alzheimer brain tissue. Brain Res. 1992, 579, 337-341.
-
(1992)
Brain Res.
, vol.579
, pp. 337-341
-
-
McGeer, P.L.1
Kawamata, T.2
Walker, D.G.3
-
121
-
-
0028137807
-
Clusterin (SGP-2): A multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain
-
Pasinetti, G. M.; Johnson, S. A.; Oda, T.; Rozovsky, I.; Finch, C. E. Clusterin (SGP-2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain. J. Comp Neurol. 1994, 339, 387-400.
-
(1994)
J. Comp Neurol.
, vol.339
, pp. 387-400
-
-
Pasinetti, G.M.1
Johnson, S.A.2
Oda, T.3
Rozovsky, I.4
Finch, C.E.5
-
122
-
-
0028921915
-
Characterization of apolipoprotein J-Alzheimer's A beta interaction
-
Matsubara, E.; Frangione, B.; Ghiso, J. Characterization of apolipoprotein J-Alzheimer's A beta interaction. J. Biol. Chem. 1995, 270, 7563-7567.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7563-7567
-
-
Matsubara, E.1
Frangione, B.2
Ghiso, J.3
-
123
-
-
0034663183
-
Apolipoprotein J (clusterin) and Alzheimer's disease
-
Calero, M.; Rostagno, A.; Matsubara, E.; Zlokovic, B.; Frangione, B.; Ghiso, J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc. Res. Tech. 2000, 50, 305-315.
-
(2000)
Microsc. Res. Tech.
, vol.50
, pp. 305-315
-
-
Calero, M.1
Rostagno, A.2
Matsubara, E.3
Zlokovic, B.4
Frangione, B.5
Ghiso, J.6
-
124
-
-
2642684569
-
Possible neuroprotective role of clusterin in Alzheimer's disease: A quantitative immunocytochemical study
-
Giannakopoulos, P.; Kovari, E.; French, L. E.; Viard, I.; Hof, P. R.; Bouras, C. Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol. (Berl) 1998, 95, 387-394.
-
(1998)
Acta Neuropathol. (Berl)
, vol.95
, pp. 387-394
-
-
Giannakopoulos, P.1
Kovari, E.2
French, L.E.3
Viard, I.4
Hof, P.R.5
Bouras, C.6
-
125
-
-
9144224765
-
ApoE and Clusterin Cooperatively Suppress Abeta Levels and Deposition. Evidence that ApoE Regulates Extracellular Abets Metabolism
-
DeMattos, R. B.; Cirrito, J. R.; Parsadanian, M.; May, P. C.; O'Dell, M. A.; Taylor, J. W.; Harmony, J. A.; Aronow, B. J.; Bales, K. R.; Paul, S. M.; Holtzman, D. M. ApoE and Clusterin Cooperatively Suppress Abeta Levels and Deposition. Evidence that ApoE Regulates Extracellular Abets Metabolism. In Vivo. Neuron 2004, 41, 193-202.
-
(2004)
In Vivo. Neuron
, vol.41
, pp. 193-202
-
-
DeMattos, R.B.1
Cirrito, J.R.2
Parsadanian, M.3
May, P.C.4
O'Dell, M.A.5
Taylor, J.W.6
Harmony, J.A.7
Aronow, B.J.8
Bales, K.R.9
Paul, S.M.10
Holtzman, D.M.11
-
126
-
-
0020332417
-
Biology of serum amyloid P component
-
Pepys, M. B.; Baltz, M. L.; De Beer, F. C.; Dyck, R. F.; Holford, S.; Breathnach, S. M.; Black, M. M.; Tribe, C. R.; Evans, D. J.; Feinstein, A. Biology of serum amyloid P component. Ann. N. Y. Acad. Sci. 1982, 389, 286-298.
-
(1982)
Ann. N. Y. Acad. Sci.
, vol.389
, pp. 286-298
-
-
Pepys, M.B.1
Baltz, M.L.2
De Beer, F.C.3
Dyck, R.F.4
Holford, S.5
Breathnach, S.M.6
Black, M.M.7
Tribe, C.R.8
Evans, D.J.9
Feinstein, A.10
-
127
-
-
0030707547
-
Alzheimer's amyloid-β aggregation is modulated by the interaction of multiple factors
-
Soto, C.; Ghiso, J.; Frangione, B. Alzheimer's amyloid-β aggregation is modulated by the interaction of multiple factors. Alzheimer's Res. 1997, 3, 215-222.
-
(1997)
Alzheimer's Res.
, vol.3
, pp. 215-222
-
-
Soto, C.1
Ghiso, J.2
Frangione, B.3
-
128
-
-
0029010736
-
Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis
-
Tennent, G. A.; Lovat, L. B.; Pepys, M. B. Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. Proc. Natl. Acad. Sci. USA 1995, 92, 4299-4303.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4299-4303
-
-
Tennent, G.A.1
Lovat, L.B.2
Pepys, M.B.3
-
129
-
-
0030757182
-
Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene
-
Botto, M.; Hawkins, P. N.; Bickerstaff, M. C.; Herbert, J.; Bygrave, A. E.; McBride, A.; Hutchinson, W. L.; Tennent, G. A.; Walport, M. J.; Pepys, M. B. Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene. Nat. Med. 1997, 3, 855-859.
-
(1997)
Nat. Med.
, vol.3
, pp. 855-859
-
-
Botto, M.1
Hawkins, P.N.2
Bickerstaff, M.C.3
Herbert, J.4
Bygrave, A.E.5
McBride, A.6
Hutchinson, W.L.7
Tennent, G.A.8
Walport, M.J.9
Pepys, M.B.10
-
130
-
-
0037118028
-
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
-
Pepys, M. B.; Herbert, J.; Hutchinson, W. L.; Tennent, G. A.; Lachmann, H. J.; Gallimore, J. R.; Lovat, L. B.; Bartfai, T.; Alanine, A.; Hertel, C.; Hoffmann, T.; Jakob-Roetne, R.; Norcross, R. D.; Kemp, J. A.; Yamamura, K.; Suzuki, M.; Taylor, G. W.; Murray, S.; Thompson, D.; Purvis, A.; Kolstoe, S.; Wood, S. P.; Hawkins, P. N. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 2002, 417, 254-259.
-
(2002)
Nature
, vol.417
, pp. 254-259
-
-
Pepys, M.B.1
Herbert, J.2
Hutchinson, W.L.3
Tennent, G.A.4
Lachmann, H.J.5
Gallimore, J.R.6
Lovat, L.B.7
Bartfai, T.8
Alanine, A.9
Hertel, C.10
Hoffmann, T.11
Jakob-Roetne, R.12
Norcross, R.D.13
Kemp, J.A.14
Yamamura, K.15
Suzuki, M.16
Taylor, G.W.17
Murray, S.18
Thompson, D.19
Purvis, A.20
Kolstoe, S.21
Wood, S.P.22
Hawkins, P.N.23
more..
-
131
-
-
0029661902
-
alpha-1-antichymotrypsin interaction with A beta (1-40) inhibits fibril formation but does not affect the peptide toxicity
-
Aksenova, M. V.; Aksenov, M. Y.; Butterfield, D. A.; Carney, J. M. alpha-1-antichymotrypsin interaction with A beta (1-40) inhibits fibril formation but does not affect the peptide toxicity. Neurosci. Lett. 1996, 211, 45-48.
-
(1996)
Neurosci. Lett.
, vol.211
, pp. 45-48
-
-
Aksenova, M.V.1
Aksenov, M.Y.2
Butterfield, D.A.3
Carney, J.M.4
-
132
-
-
0029740323
-
A specific structural interaction of Alzheimer's peptide A beta 1-42 with alpha 1-antichymotrypsin
-
Janciauskiene, S.; Eriksson, S.; Wright, H. T. A specific structural interaction of Alzheimer's peptide A beta 1-42 with alpha 1-antichymotrypsin. Nat. Struct. Biol. 1996, 3, 668-671.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 668-671
-
-
Janciauskiene, S.1
Eriksson, S.2
Wright, H.T.3
-
133
-
-
0035282790
-
Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
-
Nilsson, L. N.; Bales, K. R.; DiCarlo, G.; Gordon, M. N.; Morgan, D.; Paul, S. M.; Potter, H. Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 2001, 21, 1444-1451.
-
(2001)
J. Neurosci.
, vol.21
, pp. 1444-1451
-
-
Nilsson, L.N.1
Bales, K.R.2
DiCarlo, G.3
Gordon, M.N.4
Morgan, D.5
Paul, S.M.6
Potter, H.7
-
134
-
-
0035997225
-
Laminin affects polymerization, depolymerization and neurotoxicity of Abeta peptide
-
Morgan, C.; Bugueno, M. P.; Garrido, J.; Inestrosa, N. C. Laminin affects polymerization, depolymerization and neurotoxicity of Abeta peptide. Peptides 2002, 23, 1229-1240.
-
(2002)
Peptides
, vol.23
, pp. 1229-1240
-
-
Morgan, C.1
Bugueno, M.P.2
Garrido, J.3
Inestrosa, N.C.4
-
135
-
-
0035827348
-
Transthyretin amyloidosis: A tale of weak interactions
-
Saraiva, M. J. Transthyretin amyloidosis: a tale of weak interactions. FEBS Lett. 2001, 498, 201-203.
-
(2001)
FEBS Lett.
, vol.498
, pp. 201-203
-
-
Saraiva, M.J.1
-
136
-
-
0024273721
-
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease
-
Snow, A. D.; Mar, H.; Nochlin, D.; Kimata, K.; Kato, M.; Suzuki, S.; Hassell, J.; Wight, T. N. The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am. J. Pathol. 1988, 133, 456-463.
-
(1988)
Am. J. Pathol.
, vol.133
, pp. 456-463
-
-
Snow, A.D.1
Mar, H.2
Nochlin, D.3
Kimata, K.4
Kato, M.5
Suzuki, S.6
Hassell, J.7
Wight, T.N.8
-
137
-
-
0024387388
-
Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses
-
Snow, A. D.; Wight, T. N. Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses. Neurobiol. Aging 1989, 10, 481-497.
-
(1989)
Neurobiol. Aging
, vol.10
, pp. 481-497
-
-
Snow, A.D.1
Wight, T.N.2
-
138
-
-
0030725311
-
Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability
-
Castillo, G. M.; Ngo, C.; Cummings, J.; Wight, T. N.; Snow, A. D. Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability. J. Neurochem. 1997, 69, 2452-2465.
-
(1997)
J. Neurochem.
, vol.69
, pp. 2452-2465
-
-
Castillo, G.M.1
Ngo, C.2
Cummings, J.3
Wight, T.N.4
Snow, A.D.5
-
139
-
-
0033572813
-
Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth
-
McLaurin, J.; Franklin, T.; Zhang, X.; Deng, J.; Fraser, P. E. Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth. Eur. J. Biochem. 1999, 266, 1101-1110.
-
(1999)
Eur. J. Biochem.
, vol.266
, pp. 1101-1110
-
-
McLaurin, J.1
Franklin, T.2
Zhang, X.3
Deng, J.4
Fraser, P.E.5
-
141
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk, D.; Barbour, R.; Dunn, W.; Gordon, G.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Liao, Z.; Lieberburg, I.; Mutter, R.; Mutter, L.; Soriano, F.; Shopp, G.; Vasquez, N.; Vandevert, C.; Walker, S.; Wogulis, M.; Yednock, T.; Games, D.; Seubert, P. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400, 173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Mutter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
142
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard, F.; Cannon, C.; Barbour, R.; Burke, R. L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Lieberburg, I.; Motter, R.; Nguyen, M.; Soriano, F.; Vasquez, N.; Weiss, K.; Welch, B.; Seubert, P.; Schenk, D.; Yednock, T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 2000, 6, 916-919.
-
(2000)
Nat. Med.
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
143
-
-
0037112201
-
Cerebral hemorrhage after passive anti-Abeta immunotherapy
-
Pfeifer, M.; Boncristiano, S.; Bondolfi, L.; Stalder, A.; Deller, T.; Staufenbiel, M.; Mathews, P. M.; Jucker, M. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 2002, 298, 1379.
-
(2002)
Science
, vol.298
, pp. 1379
-
-
Pfeifer, M.1
Boncristiano, S.2
Bondolfi, L.3
Stalder, A.4
Deller, T.5
Staufenbiel, M.6
Mathews, P.M.7
Jucker, M.8
-
144
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer, A. J.; Bullock, R.; Jones, R. W.; Wilkinson, D.; Paterson, K. R.; Jenkins, L.; Millais, S. B.; Donoghue, S. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 2005, 64, 94-101.
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
Wilkinson, D.4
Paterson, K.R.5
Jenkins, L.6
Millais, S.B.7
Donoghue, S.8
-
145
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo, J. M.; Gilman, S.; Dartigues, J. F.; Laurent, B.; Puel, M.; Kirby, L. C.; Jouanny, P.; Dubois, B.; Eisner, L.; Flitman, S.; Michel, B. F.; Boada, M.; Frank, A.; Hock, C. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003, 61, 46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
Kirby, L.C.6
Jouanny, P.7
Dubois, B.8
Eisner, L.9
Flitman, S.10
Michel, B.F.11
Boada, M.12
Frank, A.13
Hock, C.14
-
146
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock, C.; Konietzko, U.; Streffer, J. R.; Tracy, J.; Signorell, A.; Muller-Tillmanns, B.; Lemke, U.; Henke, K.; Moritz, E.; Garcia, E.; Wollmer, M. A.; Umbricht, D.; de Quervain, D. J.; Hofmann, M.; Maddalena, A.; Papassotiropoulos, A.; Nitsch, R. M. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003, 38, 547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
Muller-Tillmanns, B.6
Lemke, U.7
Henke, K.8
Moritz, E.9
Garcia, E.10
Wollmer, M.A.11
Umbricht, D.12
de Quervain, D.J.13
Hofmann, M.14
Maddalena, A.15
Papassotiropoulos, A.16
Nitsch, R.M.17
-
147
-
-
5144233110
-
Update on Elan vaccine for Alzheimer's disease
-
Spinney, L. Update on Elan vaccine for Alzheimer's disease. Lancet Neurol. 2004, 3, 5.
-
(2004)
Lancet Neurol.
, vol.3
, pp. 5
-
-
Spinney, L.1
-
148
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll, J. A.; Wilkinson, D.; Holmes, C.; Steart, P.; Markham, H.; Weller, R. O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 2003, 9, 448-452.
-
(2003)
Nat. Med.
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
149
-
-
12444268257
-
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide
-
Agadjanyan, M. G.; Ghochikyan, A.; Petrushina, I.; Vasilevko, V.; Movsesyan, N.; Mkrtichyan, M.; Saing, T.; Cribbs, D. H. Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide. J. Immunol. 2005, 174, 1580-1586.
-
(2005)
J. Immunol.
, vol.174
, pp. 1580-1586
-
-
Agadjanyan, M.G.1
Ghochikyan, A.2
Petrushina, I.3
Vasilevko, V.4
Movsesyan, N.5
Mkrtichyan, M.6
Saing, T.7
Cribbs, D.H.8
-
150
-
-
3242694207
-
An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives
-
Sigurdsson, E. M.; Knudsen, E.; Asuni, A.; Fitzer-Attas, C.; Sage, D.; Quartermain, D.; Goni, F.; Frangione, B.; Wisniewski, T. An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. J. Neurosci. 2004, 24, 6277-6282.
-
(2004)
J. Neurosci.
, vol.24
, pp. 6277-6282
-
-
Sigurdsson, E.M.1
Knudsen, E.2
Asuni, A.3
Fitzer-Attas, C.4
Sage, D.5
Quartermain, D.6
Goni, F.7
Frangione, B.8
Wisniewski, T.9
-
151
-
-
16244379191
-
Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid beta-protein and GM-CSF
-
Kim, H. D.; Cao, Y.; Kong, F. K.; Van Kampen, K. R.; Lewis, T. L.; Ma, Z.; Tang, D. C.; Fukuchi, K. Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid beta-protein and GM-CSF. Vaccine 2005, 23, 2977-2986.
-
(2005)
Vaccine
, vol.23
, pp. 2977-2986
-
-
Kim, H.D.1
Cao, Y.2
Kong, F.K.3
Van Kampen, K.R.4
Lewis, T.L.5
Ma, Z.6
Tang, D.C.7
Fukuchi, K.8
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