Engineering a memory with LTD and LTP

Nature

Volumn 511, Issue 7509, 2014, Pages 348-352

  Nabavi, Sadegh ^a   Fox, Rocky ^a   Proulx, Christophe D ^a   Lin, John Y ^b   Tsien, Roger Y ^b,c   Malinow, Roberto ^a  

^a University of California San Diego   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARPROFEN;

AUDITORY CUE; BIOENGINEERING; CELL ORGANELLE; MEMORY;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; ENGINEERING; EVOKED VISUAL RESPONSE; FEAR; FOOTSHOCK; IN VITRO STUDY; IN VIVO STUDY; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MALE; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; OPTOGENETICS; PRIORITY JOURNAL; RAT; STIMULATION;

ANIMALIA;

AMYGDALA; ANIMALS; CONDITIONING (PSYCHOLOGY); ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEAR; LONG-TERM POTENTIATION; LONG-TERM SYNAPTIC DEPRESSION; MALE; MEMORY; OPTOGENETICS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84904464246     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13294     Document Type: Article

References (37)

1. Squire, L. R. & Kandel, E. R. Memory: From Mind to Molecules 2nd edn (Roberts & Co., 2009).
2. Stevens, C. F. A million dollar question: does LTP 5 memory? Neuron 20, 1-2 (1998).
3. LeDoux, J. E. Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184 (2000).
4. Fanselow, M. S. & Poulos, A. M. The neuroscience of mammalian associative learning. Annu. Rev. Psychol. 56, 207-234 (2005).
5. Maren, S.&Quirk, G. J.Neuronal signalling of fearmemory. Nature Rev.Neurosci. 5, 844-852 (2004).
6. Davis, M. The role of the amygdala in fear and anxiety. Annu. Rev. Neurosci. 15, 353-375 (1992).
7. Sah, P.,Westbrook, R. F.&Luthi, A. Fear conditioning and long-termpotentiation in the amygdala: what really is the connection? Ann. NY Acad. Sci. 1129, 88-95 (2008).
8. Pape, H. C. & Pare, D. Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear. Physiol. Rev. 90, 419-463 (2010).
9. Repa, J. C. et al. Two different lateral amygdala cell populations contribute to the initiation and storage of memory. Nature Neurosci. 4, 724-731 (2001).
10. Lin, J. Y., Lin, M. Z., Steinbach, P. & Tsien, R. Y. Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys. J. 96, 1803-1814 (2009).
11. Muller, D., Joly, M.&Lynch, G.Contributions of quisqualate andNMDAreceptors to the induction and expression of LTP. Science 242, 1694-1697 (1988).
12. Kauer, J. A., Malenka, R. C. & Nicoll, R. A. A persistent postsynaptic modification mediates long-termpotentiation in the hippocampus.Neuron 1, 911-917 (1988).
13. Mulkey, R. M.& Malenka, R. C. Mechanisms underlying induction of homosynaptic long-termdepression in area CA1 of the hippocampus. Neuron 9, 967-975 (1992).
14. Herry,C. et al.Neuronal circuitsof fear extinction. Eur. J.Neurosci. 31,599-612(2010).
15. Morris, R. G., Anderson, E., Lynch, G. S. & Baudry, M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-776 (1986).
16. Silva, A. J., Paylor, R., Wehner, J. M. & Tonegawa, S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257, 206-211 (1992).
17. Silva, A. J., Stevens, C. F., Tonegawa, S.&Wang, Y. Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 257, 201-206 (1992).
18. Whitlock, J. R., Heynen, A. J., Shuler, M. G.& Bear, M. F. Learning induces long-term potentiation in the hippocampus. Science 313, 1093-1097 (2006).
19. Rumpel, S., Ledoux, J., Zador, A. & Malinow, R. Postsynaptic receptor trafficking underlying a form of associative learning. Science 308, 83-88 (2005).
20. Rogan, M. T., Stäubli, U. V. & LeDoux, J. E. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390, 604-607 (1997).
21. McKernan, M. G. & Shinnick-Gallagher, P. Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature 390, 607-611 (1997).
22. Martin, S. J. & Morris, R. G. M. New life in an old idea: the synaptic plasticity and memory hypothesis revisited. Hippocampus 12, 609-636 (2002).
23. Li, H. et al. Experience-dependent modification of a central amygdala fear circuit. Nature Neurosci. 16, 332-339 (2013).
24. Paré, D., Quirk, G. J.&Ledoux, J. E.Newvistas onamygdalanetworks in conditioned fear. J. Neurophysiol. 92, 1-9 (2004).
25. Wilensky, A. E., Schafe, G. E., Kristensen, M. P. & LeDoux, J. E. Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J. Neurosci. 26, 12387-12396 (2006).
26. Ciocchi, S. et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 468, 277-282 (2010).
27. Liu, X. et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484, 381-385 (2012).
28. Garner, A. R. et al. Generation of a synthetic memory trace. Science 335, 1513-1516 (2012).
29. Ramirez, S. et al. Creating a false memory in the hippocampus. Science 341, 387-391 (2013).
30. Lin, J. Y.,Knutsen, P. M.,Muller, A., Kleinfeld, D.&Tsien, R. Y.ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nature Neurosci. 16, 1499-1508 (2013).
31. Kirby, E. D., Jensen, K., Goosens, K. A. & Kaufer, D. Stereotaxic surgery for excitotoxic lesion of specific brain areas in the adult rat. JoVE 65, e4079 (2012).
32. Li, X. F., Stutzmann, G. E. & LeDoux, J. E. Convergent but temporally separated inputs to lateral amygdala neurons from the auditory thalamus and auditory cortex use different postsynaptic receptors: in vivo intracellular and extracellular recordings in fear conditioning pathways. Learn Mem. 3, 229-242 (1996).
33. Rumpel, S., LeDoux, J., Zador, A. & Malinow, R. Postsynaptic receptor trafficking underlying a form of associative learning. Science 308, 83-88 (2005).
34. Li, B. et al. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 470, 535-539 (2011).
35. Hoffman, D. A. & Johnston, D. Downregulation of transient K1 channels in dendrites of hippocampal CA1 pyramidal neurons by activation ofPKA and PKC. J. Neurosci. 18, 3521-3528 (1998).
36. Chen, B. T. et al. Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron 59, 288-297 (2008).
37. Rogan, M. T. & LeDoux, J. E. LTP is accompanied by commensurate enhancement of auditory-evokedresponses in a fear conditioningcircuit.Neuron 15, 127-136 (1995).