Novel analgesic/anti-inflammatory agents: Diarylpyrrole acetic esters endowed with nitric oxide releasing properties

Journal of Medicinal Chemistry

Volumn 54, Issue 22, 2011, Pages 7759-7771

  Biava, Mariangela ^a,g   Porretta, Giulio Cesare ^a   Poce, Giovanna ^a   Battilocchio, Claudio ^a   Alfonso, Salvatore ^a   Rovini, Michele ^b   Valenti, Salvatore ^b   Giorgi, Gianluca ^b   Calderone, Vincenzo ^c   Martelli, Alma ^c   Testai, Lara ^c   Sautebin, Lidia ^d   Rossi, Antonietta ^d   Papa, Giuseppina ^d   Ghelardini, Carla ^e   Di Cesare Mannelli, Lorenzo ^e   Giordani, Antonio ^f   Anzellotti, Paola ^g   Bruno, Annalisa ^g   Patrignani, Paola ^g   Anzini, Maurizio ^b   more..

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

^f Rotta Research Laboratorium   (Italy)

^g UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 DIARYLPYRROLE 3 ACETIC NITROXYALKYL; 2 (NITROXY)ETHYL 2 [1 (4 METHYLTHIO)PHENYL] 2 METHYL 5[4(METHYLSULFONYL)PHENYL] 1H PYRROL 3YL]ACETATE; 2 HYDROXYETHYL 2 1 (4 METHYLTHIOPHENYL) 2 METHYL 5 [4 (METHYLSULFONYL)PHENYL] 1H PYRROL 3 YL]ACETATE; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ESTER DERIVATIVE; NITRIC OXIDE; PROSTAGLANDIN E2; THROMBOXANE B2; UNCLASSIFIED DRUG;

ADULT; ANALGESIC ACTIVITY; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; ENZYME RELEASE; EX VIVO STUDY; FEMALE; HUMAN; IC 50; IN VIVO STUDY; MALE; NONHUMAN; RAT; VASODILATATION;

ACETATES; ANIMALS; CELL LINE; CONSTRICTION, PATHOLOGIC; CYCLOOXYGENASE 2 INHIBITORS; EDEMA; ESTERS; HUMANS; HYPERALGESIA; ISOENZYMES; MACROPHAGES; MALE; MICE; MODELS, MOLECULAR; NITRIC OXIDE DONORS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS;

EID: 81555218668     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200715n     Document Type: Article

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