Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 10, 2015, Pages 2368-2376

  Bozdag, Murat ^a   Carta, Fabrizio ^a   Vullo, Daniela ^a   Akdemir, Atilla ^b   Isik, Semra ^a   Lanzi, Cecilia ^a   Scozzafava, Andrea ^a   Masini, Emanuela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b BEZMIALEM VAKIF UNIVERSITY   (Turkey)

Author keywords

Antiglaucoma; Carbonic anhydrase; Dithiocarbamate; Intraocular pressure

Indexed keywords

ANTIHYPERTENSIVE AGENT; CARBON DISULFIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; DORZOLAMIDE; MORPHOLINE DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SULFONAMIDE; THIOCARBAMIC ACID DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ENZYME SPECIFICITY; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MALE; METABOLISM; MOLECULAR DOCKING; PATHOPHYSIOLOGY; RABBIT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CARBON DISULFIDE; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DISEASE MODELS, ANIMAL; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; MALE; MOLECULAR DOCKING SIMULATION; MORPHOLINES; PIPERAZINES; PIPERIDINES; QUINUCLIDINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFONAMIDES; THIOCARBAMATES; THIOPHENES;

EID: 84937763458     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.068     Document Type: Article

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