More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 28, Issue 2, 2013, Pages 350-359

  Avram, Speranta ^a   Milac, Adina Luminita ^b   Carta, Fabrizio ^c   Supuran, Claudiu T ^c  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b INSTITUTE OF BIOCHEMISTRY OF THE ROMANIAN ACADEMY   (Romania)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antitumoral; Drug design; Molecular descriptor; Statistical analysis; Tumorigenesis

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DICARBOXYLIC ACID DERIVATIVE; DITHIOCARBAMIC ACID DERIVATIVE; ESTER DERIVATIVE; ISOENZYME; CARBONATE DEHYDRATASE INHIBITOR; ISOPROTEIN; THIOCARBAMIC ACID DERIVATIVE;

ACID BASE BALANCE; ARTICLE; DRUG EFFICACY; ENZYME INHIBITION; HYDROPHOBICITY; MATHEMATICAL COMPUTING; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOSPECIFICITY; ALGORITHM; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DOSE RESPONSE; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; SYNTHESIS;

ALGORITHMS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN ISOFORMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

EID: 84891384166     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2012.727410     Document Type: Article

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