-
1
-
-
84863501358
-
Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms?
-
Alterio V, Di Fiore A, D'Ambrosio K et al (2012) Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? Chem Rev 112:4421-4468
-
(2012)
Chem Rev
, vol.112
, pp. 4421-4468
-
-
Alterio, V.1
Di Fiore, A.2
D'Ambrosio, K.3
-
2
-
-
0033931053
-
Structural studies of matrix metalloproteinases
-
Borkakoti N (2000) Structural studies of matrix metalloproteinases. J Mol Med 78:261-268
-
(2000)
J Mol Med
, vol.78
, pp. 261-268
-
-
Borkakoti, N.1
-
3
-
-
0028382506
-
Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor
-
Borkakoti N, Winkler FK, Williams DH et al (1994) Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor. Nat Struct Biol 1:106-110
-
(1994)
Nat Struct Biol
, vol.1
, pp. 106-110
-
-
Borkakoti, N.1
Winkler, F.K.2
Williams, D.H.3
-
5
-
-
0032708011
-
Carbonic anhydrase catalyzes cyanamide hydration to urea: Is it mimicking the physiological reaction?
-
Briganti F, Mangani S, Scozzafava A et al (1999) Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? J Biol Inorg Chem 4:528-536
-
(1999)
J Biol Inorg Chem
, vol.4
, pp. 528-536
-
-
Briganti, F.1
Mangani, S.2
Scozzafava, A.3
-
6
-
-
0007493518
-
Structure-function relationship between the carbonic anhydrases and the zinc proteases
-
Botrè F, Gros G, Storey BT eds, VCH, New York
-
Christianson DW, Ippolito JA (1991) Structure-function relationship between the carbonic anhydrases and the zinc proteases. In: Botrè F, Gros G, Storey BT (eds) Carbonic Anhydrase. VCH, New York, pp 95-110
-
(1991)
Carbonic Anhydrase
, pp. 95-110
-
-
Christianson, D.W.1
Ippolito, J.A.2
-
8
-
-
84864690761
-
Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors
-
Di Fiore A, Maresca A, Supuran CT, De Simone G (2012) Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors. Chem Commun 48:8838-8840
-
(2012)
Chem Commun
, vol.48
, pp. 8838-8840
-
-
Di Fiore, A.1
Maresca, A.2
Supuran, C.T.3
De Simone, G.4
-
9
-
-
0037320183
-
A comparative QSAR study on carbonic anhydrase and matrix metalloproteinase inhibition by sulfonylated amino acid hydroxamates
-
Gupta SP, Maheswaran V, Pande V, Kumar D (2003) A comparative QSAR study on carbonic anhydrase and matrix metalloproteinase inhibition by sulfonylated amino acid hydroxamates. J Enzyme Inhib Med Chem 18:7-13
-
(2003)
J Enzyme Inhib Med Chem
, vol.18
, pp. 7-13
-
-
Gupta, S.P.1
Maheswaran, V.2
Pande, V.3
Kumar, D.4
-
10
-
-
0033048045
-
Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors
-
Lovejoy B, Welch AR, Carr S et al (1999) Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors. Nat Struct Biol 6:217-221
-
(1999)
Nat Struct Biol
, vol.6
, pp. 217-221
-
-
Lovejoy, B.1
Welch, A.R.2
Carr, S.3
-
11
-
-
58149086406
-
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: Iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates
-
Marques SM, Nuti E, Rossello A et al (2008) Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates. J Med Chem 51:7968-7979
-
(2008)
J Med Chem
, vol.51
, pp. 7968-7979
-
-
Marques, S.M.1
Nuti, E.2
Rossello, A.3
-
12
-
-
0033618337
-
Matrix metalloproteinases
-
Nagase H, Woessner JF (1999) Matrix metalloproteinases. J Biol Chem 274:21491-21494
-
(1999)
J Biol Chem
, vol.274
, pp. 21491-21494
-
-
Nagase, H.1
Woessner, J.F.2
-
13
-
-
80053563164
-
Interfering with pH regulation in tumours as a therapeutic strategy
-
Neri D, Supuran CT (2011) Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov 10:767-777
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 767-777
-
-
Neri, D.1
Supuran, C.T.2
-
14
-
-
33847161733
-
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated isoforms I, II and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties
-
Santos MA, Marques S, Vullo D et al (2007) Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated isoforms I, II and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties. Bioorg Med Chem Let 17:1538-1543
-
(2007)
Bioorg Med Chem Let
, vol.17
, pp. 1538-1543
-
-
Santos, M.A.1
Marques, S.2
Vullo, D.3
-
15
-
-
0031054004
-
Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase II
-
Scolnick LR, Clements AM, Liao J et al (1997) Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase II. J Am Chem Soc 119:850-851
-
(1997)
J Am Chem Soc
, vol.119
, pp. 850-851
-
-
Scolnick, L.R.1
Clements, A.M.2
Liao, J.3
-
16
-
-
0033566151
-
Carbonic anhydrase inhibitors: Synthesis of water-soluble, topically effective intraocular pressure lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: Is the tail more important than the ring?
-
Scozzafava A, Menabuoni L, Mincione F et al (1999) Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring? J Med Chem 42:2641-2650
-
(1999)
J Med Chem
, vol.42
, pp. 2641-2650
-
-
Scozzafava, A.1
Menabuoni, L.2
Mincione, F.3
-
17
-
-
0034609778
-
Carbonic anhydrase and matrix metalloproteinase inhibitors. Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of carbonic anhydrase isozymes I, II and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes
-
Scozzafava A, Supuran CT (2000a) Carbonic anhydrase and matrix metalloproteinase inhibitors. Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of carbonic anhydrase isozymes I, II and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:3677-3687
-
(2000)
J Med Chem
, vol.43
, pp. 3677-3687
-
-
Scozzafava, A.1
Supuran, C.T.2
-
18
-
-
0034110863
-
Protease inhibitors. Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido-glycine hydroxamate inhibitors of Clostridium histolyticum collagenase
-
Scozzafava A, Supuran CT (2000b) Protease inhibitors. Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido-glycine hydroxamate inhibitors of Clostridium histolyticum collagenase. Eur J Med Chem 35:299-307
-
(2000)
Eur J Med Chem
, vol.35
, pp. 299-307
-
-
Scozzafava, A.1
Supuran, C.T.2
-
19
-
-
0034611436
-
Protease inhibitors. Part 9. Synthesis of Clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties
-
Scozzafava A, Supuran CT (2000c) Protease inhibitors. Part 9. Synthesis of Clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties. Bioorg Med Chem Lett 10:499-502
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 499-502
-
-
Scozzafava, A.1
Supuran, C.T.2
-
20
-
-
0037447909
-
Hydroxyurea is a carbonic anhydrase inhibitor
-
Scozzafava A, Supuran CT (2003) Hydroxyurea is a carbonic anhydrase inhibitor. Bioorg Med Chem 11:2241-2246
-
(2003)
Bioorg Med Chem
, vol.11
, pp. 2241-2246
-
-
Scozzafava, A.1
Supuran, C.T.2
-
21
-
-
38849143765
-
Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
-
Supuran CT (2008) Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 7:168-181
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 168-181
-
-
Supuran, C.T.1
-
22
-
-
77954218410
-
Carbonic anhydrase inhibitors
-
Supuran CT (2010) Carbonic anhydrase inhibitors. Bioorg Med Chem Lett 20:3467-3474
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 3467-3474
-
-
Supuran, C.T.1
-
23
-
-
79961070760
-
Carbonic anhydrase inhibitors and activators for novel therapeutic applications
-
Supuran CT (2011) Carbonic anhydrase inhibitors and activators for novel therapeutic applications. Future Med Chem 3:1165-1180
-
(2011)
Future Med Chem
, vol.3
, pp. 1165-1180
-
-
Supuran, C.T.1
-
24
-
-
84865850354
-
Structure-based drug discovery of carbonic anhydrase inhibitors
-
Supuran CT (2012) Structure-based drug discovery of carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 27:759-772
-
(2012)
J Enzyme Inhib Med Chem
, vol.27
, pp. 759-772
-
-
Supuran, C.T.1
-
25
-
-
0001794971
-
Matrix metalloproteinases (MMPs)
-
Smith HJ, Simons C, Eds., Taylor & Francis, London
-
Supuran CT, Scozzafava A (2002) Matrix metalloproteinases (MMPs). In proteinase and peptidase inhibition: recent potential targets for drug development, Smith HJ, Simons C, Eds., Taylor & Francis, London, pp 35-61
-
(2002)
Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development
, pp. 35-61
-
-
Supuran, C.T.1
Scozzafava, A.2
-
26
-
-
84889354211
-
Introduction to zinc enzymes as drug targets
-
Supuran CT, Winum JY eds, Wiley, Hoboken
-
Supuran CT, Winum JY (2009) Introduction to zinc enzymes as drug targets. In: Supuran CT, Winum JY (eds) Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications. Wiley, Hoboken, pp 3-12
-
(2009)
Drug Design of Zinc-enzyme Inhibitors: Functional, Structural, and Disease Applications
, pp. 3-12
-
-
Supuran, C.T.1
Winum, J.Y.2
-
27
-
-
33745778881
-
N-Hydroxyurea-a versatile zinc binding function in the design of metalloenzyme inhibitors
-
Temperini C, Innocenti A, Scozzafava A, Supuran CT (2006) N-Hydroxyurea-a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett 16:4316-4320
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 4316-4320
-
-
Temperini, C.1
Innocenti, A.2
Scozzafava, A.3
Supuran, C.T.4
-
28
-
-
0019880981
-
A continuous spectrophotometric assay for Clostridium histolyticum collagenase
-
Van Wart HE, Steinbrink DR (1981) A continuous spectrophotometric assay for Clostridium histolyticum collagenase. Anal Biochem 113:156-165
-
(1981)
Anal Biochem
, vol.113
, pp. 156-165
-
-
Van Wart, H.E.1
Steinbrink, D.R.2
-
29
-
-
0001651169
-
Design and therapeutic application of matrix metalloproteinase inhibitors
-
Whittaker M, Floyd CD, Brown P, Gearing AJH (1999) Design and therapeutic application of matrix metalloproteinase inhibitors. Chem Rev 99:2735-2776
-
(1999)
Chem Rev
, vol.99
, pp. 2735-2776
-
-
Whittaker, M.1
Floyd, C.D.2
Brown, P.3
Gearing, A.J.H.4
|