Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2521-2526

  Carta, Fabrizio ^a   Innocenti, Alessio ^a   Hall, Rebecca A ^b   Mühlschlegel, Fritz A ^b   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Class enzyme; Antifungals; Candida albicans; Carbonic anhydrase; Carboxylate; Cryptococcus neoformans; Inhibitor

Indexed keywords

AROMATIC COMPOUND; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBOXYLIC ACID DERIVATIVE;

ARTICLE; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; CRYSTAL STRUCTURE; DRUG SELECTIVITY; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CANDIDA ALBICANS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CARBOXYLIC ACIDS; CRYPTOCOCCUS NEOFORMANS; FUNGAL PROTEINS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA ALBICANS; FILOBASIDIELLA NEOFORMANS; FUNGI;

EID: 79953278558     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.057     Document Type: Article

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