Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 19216-19228

  Pauls, Eduardo ^a   Shpiro, Natalia ^a   Peggie, Mark ^a   Young, Erick R ^b   Sorcek, Ronald J ^b   Tan, Li ^c   Choi, Hwan Geun ^c   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINES; PHARMACOLOGICAL INHIBITORS; PLASMACYTOID DENDRITIC CELLS; PROINFLAMMATORY CYTOKINES; PROTEIN KINASE; SIGNALING PATHWAYS;

ANTIBIOTICS; BIOACTIVITY; CELL CULTURE; CELLS; DEGRADATION; GLYCOPROTEINS; IMMUNOLOGY; PIGMENTS; RNA; SIGNALING;

LIGANDS;

6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; [4 [4 [(2,3 DIHYDRO 1H INDEN 1 YL)AMINO] 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL] 2 HYDROXYCYCLOPENTYLMETHYL] SULFAMATE; ALPHA INTERFERON; BETA INTERFERON; BI 605906; CL 097; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE INHIBITOR; INTERLEUKIN 6; JANUS KINASE; LIGAND; RESIQUIMOD; STAT1 PROTEIN; STAT2 PROTEIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMACYTOID DENDRITIC CELL; POLYUBIQUITYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

ANIMALS; DENDRITIC CELLS; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-6; JANUS KINASES; MEMBRANE GLYCOPROTEINS; MICE; NF-KAPPA B; PLASMA CELLS; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; THYMIDINE KINASE; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84861728909     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.345405     Document Type: Article

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