IKKβ is an IRF5 kinase that instigates inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 49, 2014, Pages 17438-17443

  Ren, Junyao ^a   Chen, Xiang ^a   Chen, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

IKK; Inflammation; IRF5; Phosphorylation; TLR

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; DNA DIRECTED RNA POLYMERASE III; DOUBLE STRANDED RNA; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PHOSPHOSPECIFIC ANTIBODY; POLY(DEOXYADENYLATE DEOXYTHYMIDYLATE); RETINOIC ACID; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; ALANINE; CYTOKINE; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKB PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, HUMAN; IRF5 PROTEIN, MOUSE; SERINE;

ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DIMERIZATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MASS SPECTROMETRY; MOUSE; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; NONHUMAN; POINT MUTATION; PROTEIN PHOSPHORYLATION; SENDAI VIRUS INFECTION; ANIMAL; CHEMISTRY; HEK293 CELL LINE; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

ALANINE; ANIMALS; CYTOKINES; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INTERFERON REGULATORY FACTORS; MASS SPECTROMETRY; MICE; MUTATION; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SERINE;

EID: 84916201016     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418516111     Document Type: Article

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