Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 49, 2014, Pages 17432-17437

  Lopez Pelaez, Marta ^a   Lamont, Douglas J ^a   Peggie, Mark ^a   Shpiro, Natalia ^a   Gray, Nathanael S ^b   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

IKK ; Interferon ; IRF5; Plasmacytoid dendritic cell; TLR7

Indexed keywords

ALPHA1 INTERFERON; CASPASE RECRUITMENT DOMAIN PROTEIN 4; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; BETA INTERFERON; I KAPPA B; I KAPPA B BETA; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, HUMAN; LIGAND; NFKB1 PROTEIN, HUMAN; SERINE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIMERIZATION; ENZYME PHOSPHORYLATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; ACTIVE TRANSPORT; ANIMAL; CELL LINE; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; INFLAMMATION; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN MULTIMERIZATION;

MURINAE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; I-KAPPA B PROTEINS; IMMUNITY, INNATE; INFLAMMATION; INTERFERON REGULATORY FACTORS; INTERFERON-BETA; LIGANDS; MICE; MICROSCOPY, FLUORESCENCE; MUTATION; NF-KAPPA B P50 SUBUNIT; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; SERINE; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84916217073     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418399111     Document Type: Article

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