Quantifying evolutionary constraints on B-cell affinity maturation

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 370, Issue 1676, 2015, Pages

  McCoy, Connor O ^a   Bedford, Trevor ^a   Minin, Vladimir N ^b   Bradley, Philip ^a   Robins, Harlan ^a   Matsen, Frederick A ^a  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Affinity maturation; Antibody; B cell; Immunoglobulin; Molecular evolution; Natural selection

Indexed keywords

ESTIMATION METHOD; GENE EXPRESSION; GENETIC DIFFERENTIATION; GERM CELL; MATURATION; MOLECULAR ANALYSIS; MUTATION; STATISTICAL ANALYSIS;

LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIBODY SPECIFICITY; ANTIGEN MEDIATED CLONAL SELECTION; B LYMPHOCYTE; BAYES THEOREM; BIOLOGICAL MODEL; CELL DIFFERENTIATION; COMPUTER SIMULATION; CYTOLOGY; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; IMMUNOLOGY; MARKOV CHAIN; MOLECULAR EVOLUTION; VDJ RECOMBINATION;

ANTIBODY DIVERSITY; B-LYMPHOCYTES; BAYES THEOREM; CELL DIFFERENTIATION; CLONAL SELECTION, ANTIGEN-MEDIATED; COMPUTER SIMULATION; EVOLUTION, MOLECULAR; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MODELS, GENETIC; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, B-CELL; STOCHASTIC PROCESSES; V(D)J RECOMBINATION;

EID: 84937698863     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2014.0244     Document Type: Article

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