Antibody-specific model of amino acid substitution for immunological inferences from alignments of antibody sequences

Molecular Biology and Evolution

Volumn 32, Issue 3, 2015, Pages 806-819

  Mirsky, Alexander ^a,b   Kazandjian, Linda ^c   Anisimova, Maria ^b,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b ETH ZURICH   (Switzerland)

^c MAB Discovery GmbH   (Germany)

^d ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

Author keywords

Alignment; Amino acid substitution; Antibody; Antibody genealogy; Evolution; Markov model; Somatic hypermutation

Indexed keywords

AMINO ACID; ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ARTICLE; BOOTSTRAPPING; CONTROLLED STUDY; HIDDEN MARKOV MODEL; HUMAN; INDEL MUTATION; LEARNING ALGORITHM; MOLECULAR EVOLUTION; MOUSE; NEXT GENERATION SEQUENCING; NONHUMAN; PHYLOGENETIC TREE; PHYSICAL CHEMISTRY; SEQUENCE ALIGNMENT; SOMATIC HYPERMUTATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; MARKOV CHAIN; MOLECULAR GENETICS; MUTATION; PROCEDURES; PROTEIN DATABASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES; DATABASES, PROTEIN; EVOLUTION, MOLECULAR; HUMANS; MARKOV CHAINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ALIGNMENT;

EID: 84982189602     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu340     Document Type: Article

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