The inference of antigen selection Ig genes

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 5122-5126

  Lossos, I S ^a   Tibshirani, R ^a   Narasimhan, B ^a   Levy, R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; FRAMESHIFT MUTATION; GENE DELETION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN GENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOMATIC MUTATION; TISSUE DISTRIBUTION;

EID: 0034326641     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.5122     Document Type: Article

References (14)

1. Clonal selection and learning in the antibody system
2. Evolutionary nucleotide replacements in DNA
3. High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia
4. Structure and function of anti-DNA antibodies derived from a single autoimmune mouse
5. The CDRI sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
6. Ongoing somatic mutations and clonal expansions after cure of Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue B-cell lymphoma
7. VH gene analysis of primary cutaneous B-cell lymphomas: Evidence for ongoing somatic hypermutation and isotype switching
8. Molecular analysis of rheumatoid factor (RF)-negative B cell hybridomas from rheumatoid synovial tissue: Evidence for an antigen-induced stimulation with selection of high mutated IgVH and low mutated IgVL/λ genes
9. Sequence analysis of V(4-34)-encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE)
10. Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis
11. + diffuse large B-cell lymphomas express VH genes with somatic mutation
12. Molecular analysis of immunoglobulin genes in diffuse large B cell lymphomas
13. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes