Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 16, 2013, Pages 6470-6475

  Zhu, Jiang ^a,b   Ofek, Gilad ^a   Yang, Yongping ^a   Zhang, Baoshan ^a   Louder, Mark K ^a   Lu, Gabriel ^a   McKee, Krisha ^a   Pancera, Marie ^a   Skinner, Jeff ^c   Zhang, Zhenhai ^d   Parks, Robert ^e   Eudailey, Joshua ^e   Lloyd, Krissey E ^e   Blinn, Julie ^e   Alam, S Munir ^e   Haynes, Barton F ^e   Simek, Melissa ^f   Burton, Dennis R ^b,g   Koff, Wayne C ^f   Mullikin, James C ^h   Mascola, John R ^a   Shapiro, Lawrence ^a,d   Kwong, Peter D ^a   more..

^a Vaccine Research Center   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Bioinformatics and Computational Biosciences Branch   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIBODY; ANTIBODYOME; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; PGT 141 145; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; GENETIC VARIABILITY; HEAVY CHAIN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOREACTIVITY; LIGHT CHAIN; NEXT GENERATION SEQUENCING; NONHUMAN; PHYLOGENETIC TREE; PHYLOGENY; PRIORITY JOURNAL; PYROSEQUENCING; SEQUENCE ANALYSIS; SOMATIC MUTATION; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HIV-1; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PHYLOGENY; SEQUENCE ALIGNMENT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84876272159     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219320110     Document Type: Article

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