Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data

Frontiers in Immunology

Volumn 4, Issue NOV, 2013, Pages

  Yaari, Gur ^a,b   Vander Heiden, Jason A ^c   Uduman, Mohamed ^b   Gadala Maria, Daniel ^c   Gupta, Namita ^c   H Stern, Joel N ^b,d   O'Connor, Kevin C ^b   Hafler, David A ^b   Laserson, Uri ^e   Vigneault, Francois ^f   Kleinstein, Steven H ^b,c  

^a BAR ILAN UNIVERSITY   (Israel)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

^d DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f AbVitro Inc   (United States)

Author keywords

Affinity maturation; AID; B cell; Immunoglobulin; Mutability; Somatic hypermutation; Substitution; Targeting

Indexed keywords

ADENOSINE; CYTIDINE; GUANINE; IMMUNOGLOBULIN; NUCLEOTIDE; THYMIDINE;

ARTICLE; B LYMPHOCYTE; COMPLEMENTARITY DETERMINING REGION; GENE TARGETING; HEDGEHOG; HUMAN; HUMAN TISSUE; LYMPH NODE; MUTATION RATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION SYSTEM; RNA EXTRACTION; SOMATIC HYPERMUTATION; SUBSTITUTION LINE;

EID: 84890364905     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00358     Document Type: Article

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