Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: Chronic activation, normal selection

Cellular Immunology

Volumn 244, Issue 2, 2006, Pages 130-136

  Steiman Shimony, Avital ^a   Edelman, Hanna ^a   Hutzler, Anat ^a   Barak, Michal ^a   Zuckerman, Neta S ^a   Shahaf, Gitit ^a   Dunn Walters, Deborah ^b   Stott, David I ^c   Abraham, Roshini S ^d   Mehr, Ramit ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d Mayo Clinic   (United States)

Author keywords

Germinal centers; Myasthenia Gravis (MG); Rheumatoid Arthritis (RA); Sj gren's Syndrome (SS); Somatic hypermutation

Indexed keywords

IMMUNOGLOBULIN;

ALGORITHM; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL CLONING; GENE MUTATION; HUMAN; PRIORITY JOURNAL;

ALGORITHMS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; CLUSTER ANALYSIS; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; STATISTICS, NONPARAMETRIC; VARIATION (GENETICS);

EID: 34248381619     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2007.01.009     Document Type: Article

References (32)

1. Jacob J., and Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176 (1992) 679-687
2. Jacob J., Przylepa J., Miller C., and Kelsoe G. In situ studies of the primary immune response to(4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178 (1993) 1293-1307
3. Dunn-Walters D.K., Belelovsky A., Edelman H., Banerjee M., and Mehr R. The dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees. Dev. Immunol. 9 (2002) 233-243
4. Dunn-Walters D.K., Edelman H., and Mehr R. Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees. BioSystems 76 (2004) 141-155
5. Banerjee M., Mehr R., Belelovsky A., Spencer J., and Dunn-Walters D.K. Age and tissue specific differences in human germinal center B cell selection revealed by analysis of IGVH gene hypermutation and lineage trees. Eur. J. Immunol. 32 (2002) 1947-1957
6. Dunn-Walters D.K., Banerjee M., and Mehr R. Age effects on antibody affinity maturation. Biochem. Soc. Trans. 31 (2003) 447-448
7. Manske M.K., Zuckerman N.S., Timm M.M., Maiden S., Edelman H., Shahaf G., Barak M., Dispenzieri A., Gertz M.A., Mehr R., and Abraham R.S. Clonal CD19+ B cells skew the Ig VL gene repertoire in the CD138-negative compartment of bone marrow in light chain Amyloidosis. Clin. Immunol. 120 (2006) 106-120
8. Abraham R.S., Manske M.K., Zuckerman N.S., Sohni A., Edelman H., Shahaf G., Timm M.M., Dispenzieri A., Gertz M.A., and Mehr R. Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis. J. Clin. Immunol. 27 (2007) 69-87
9. Youinou P., Jamin C., Pers J.O., Berthou C., Saraux A., and Renaudineau Y. B lymphocytes are required for development and treatment of autoimmune diseases. Ann. N.Y. Acad. Sci. 1050 (2005) 19-33
10. Stott D.I., Hiepe F., Hummel M., Steinhauser G., and Berek C. Sjögren's antigen-driven proliferation of B cells within the target tissue of an autoimmune disease-the salivary glands of patients with Sjögren's Syndrome. J. Clin. Invest. 102 (1998) 938-946
11. William J., Euler C., Christensen S., and Shlomchik M.J. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 297 (2002) 2066-2070
12. Sims G.P., Shiono H., Willcox N., and Stott D.I. Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in Myasthenia Gravis. J. Immunol. 16 (2001) 1935-1944
13. Serafini B., Rosicarelli B., Magliozzi R., Stigliano E., and Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 14 (2004) 164-174
14. Kim H.J., Krenn V., Steinhauser G., and Berek C. Plasma cell development in synovial germinal centers in patients with rheumatoid and Reactive Arthritis. J. Immunol. 162 (1999) 3053-3062
15. Steiman-Shimony A., Edelman H., Barak M., Shahaf G., Dunn-Walters D.K., Stott D.I., Abraham R.S., and Mehr R. Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases. Autoimmun. Rev. 5 (2006) 242-251
16. Colombo M., Dono M., Gazzola P., Roncella S., Valetto A., Chiorazzi N., Mancardi G.L., and Ferrarini M. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J. Immunol. 164 (2000) 2782-2789
17. Miura Y., Chu C.C., Dines D.M., Asnis S.E., Furie R.A., and Chiorazzi N. Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion. Mol. Med. 9 (2003) 166-174
18. Gause A., Gundlach K., Zdichavsky M., Jacobs G., Koch B., Hopf T., and Pfreundschuh M. The B lymphocyte in Rheumatoid Arthritis: analysis of rearranged V kappa genes from B cells infiltrating the synovial membrane. Eur. J. Immunol. 25 (1995) 2775-2782 Data published in Genbank (GenBank Accession Nos. X85162-X85167, Z75254, Z75333-Z75343, Z75442-Z75465).
19. Gellrich S., Rutz S., Borkowski A., Golembowski S., Gromnica-Ihle E., Sterry W., and Jahn S. Analysis of VH-D-JH Gene transcripts in B cells infiltrating the salivary glands and lymph node tissues of patients with Sjögren's Syndrome. Arth. Rhuem. 42 (1999) 240-247
20. Colombo M., Dono M., Gazzola P., Chiorazzi N., Mancardi G., and Ferrarini M. Maintenance of B lymphocyte related clones in the cerebrospinal fluid of multiple sclerosis patients. Eur. J. Immunol. 33 (2003) 3433-3438
21. Jacobi A.M., Hansen A., Kaufmann O., Pruss A., Burmester G.R., Lipsky P.E., and Dorner T. Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's Syndrome. Arthritis Res. 4 (2002) R4
22. Benjamini Y., and Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Roy. Stat. Soc. B. 57 (1995) 289-300
23. Lossos I.S., Tibshirani R., Narasimhan B., and Levy R. The inference of Ag selection on Ig genes. J. Immunol. 165 (2000) 5122-5126
24. Chang B., and Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol. Today 15 (1994) 367-373
25. Abraham R.S., Ballman K.V., Dispenzieri A., Grill D.E., Manske M.K., Price-Troska T.L., Paz N.G., Gertz M.A., and Fonseca R. Functional gene expression analysis of clonal plasma cells identifies a unique molecular profile for light chain amyloidosis. Blood 105 (2005) 794-803
26. Kuppers R., Zhao M., Hansmann M.L., and Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12 (1993) 4955-4967
27. Dorner T., Foster S.J., Farner N.L., and Lipsky P.E. Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands. Eur. J. Immunol. 28 (1998) 3384-3396
28. Stott D.I., and Berek C. An antigen-driven B-cell response within the salivary glands of patients with Sjögren's Syndrome. Annals of the Marie Curie Fellowship Association. 2 (2002) 108-116
29. Nzula S., Going J.J., and Stott D.I. Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas. Cancer Res. 63 (2003) 3275-3280
30. Dunn-Walters D.K., and Spencer J. Strong intrinsic biases towards mutation and conservation of bases in human IGVH genes during somatic hypermutation prevent statistical analysis of antigen selection. Immunology 95 (1998) 339-345
31. Bose B., and Sinha S. Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology 116 (2005) 172-183
32. Schroder A.E., Greiner A., Seyfert C., and Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with Rheumatoid Arthritis. Proc. Natl. Acad. Sci. USA 93 (1996) 221-225