Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from Cryptosporidium

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6839-6852

  Bolstad, David B ^a   Bolstad, Erin S D ^a   Frey, Kathleen M ^a   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 [3 (3 METHOXY 4 (2 METHYLPHENYL)PHENYL)BUT 1 YNYL] 6 METHYLPYRIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 4 (2,6 DIISOPROPYLPHENYL)PHENYL)BUT 1 YNYL] 6 METHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 4 (2,6 DIMETHYLPHENYL)PHENYL)BUT 1 YNYL] 6 METHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 4 PHENYLPHENYL)BUT 1 YNYL] 6 METHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 5 (2 METHYLPHENYL)PHENYL0BUT 1 YNYL] 6 METHYLPYRIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 5 (2,6 DIISOPROPYLPHENYL)PHENYL) BUT 1 YNYL] 6 METHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 5 (2,6 DIMETHYLPHENYL)PHENYL)BUT 1 YNYL] 6 METHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 (3 METHOXY 5 PHENYLPHENYL)BUT 1 YNYL] 6 METHYLPYRIMIDINE; DIHYDROFOLATE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYPTOSPORIDIUM; DRUG POTENCY; DRUG STRUCTURE;

ANIMALS; CRYPTOSPORIDIUM; FOLIC ACID ANTAGONISTS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 56249132695     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8009124     Document Type: Article

References (20)

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