Copper-catalyzed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters

Angewandte Chemie - International Edition

Volumn 44, Issue 18, 2005, Pages 2752-2756

  López, Fernando ^a   Harutyunyan, Syuzanna R ^a   Meetsma, Auke ^a   Minnaard, Adriaan J ^a   Feringa, Ben L ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Asymmetric catalysis; Conjugate addition; Copper; Enantioselectivity; Grignard reaction

Indexed keywords

ADDITION REACTIONS; COMPLEXATION; COPPER; ESTERS;

CONJUGATE ADDITION; ENANTIOSELECTIVE REAGENTS; GRIGNARD REAGENTS; OPTICALLY ACTIVE ESTERS;

CATALYSIS;

EID: 18844403662     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500317     Document Type: Article

References (51)

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48. See Supporting Information for details.
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51. 2 was prepared by the method shown in Scheme 2 and used in these reactions. The same results were obtained when 4b was prepared in situ.