Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways

Acta Pharmacologica Sinica

Volumn 36, Issue 3, 2015, Pages 362-374

  Xiong, Xin Xin ^a   Liu, Ju Mei ^a   Qiu, Xin Yao ^a   Pan, Feng ^a,b   Yu, Shang Bin ^a   Chen, Xiao Qian ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Autophagy; Ayurvedic medicine; JNK; Myelodysplastic syndrome; Myeloid leukemia; N acetyl L cysteine; P38; Piperlongumine; ROS; SB203580; SP600125

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC ALKALOID; BECLIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PIPERLONGUMINE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; PIPERLONGUMININE; PROTEIN KINASE INHIBITOR;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AGED; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BONE MARROW BIOPSY; BONE MARROW DERIVED MONONUCLEAR CELL; CANCER CELL CULTURE; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MYELODYSPLASTIC SYNDROME; MYELOID LEUKEMIA CELL LINE; PROTEIN PHOSPHORYLATION; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; IC50; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL SURVIVAL; DIOXOLANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PRIMARY CELL CULTURE; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84937408246     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.141     Document Type: Article

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