Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A2 receptor antagonist

European Journal of Pharmacology

Volumn 570, Issue 1-3, 2007, Pages 38-42

  Iwashita, Masaya ^a   Oka, Nobuaki ^a   Ohkubo, Satoko ^b   Saito, Masaki ^a   Nakahata, Norimichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

Piperlongumine; Platelet aggregation; Thromboxane A2 receptor

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; PHOSPHATIDYLINOSITOL; PIPER LONGUM EXTRACT; PIPERLONGUMINE; THROMBIN; THROMBOXANE A2 RECEPTOR; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYDROLYSIS; MALE; MEDICINAL PLANT; NONHUMAN; PIPER LONGUM; PRIORITY JOURNAL; RABBIT; THROMBOCYTE AGGREGATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; DIOXOLANES; HETEROCYCLIC COMPOUNDS, 1-RING; HYDRAZINES; MALE; PHOSPHATIDYLINOSITOLS; PIPER; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2;

EID: 34547849622     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.05.073     Document Type: Article

References (24)

1. Aronow W.S. Management of peripheral arterial disease of the lower extremities in elderly patients. J. Gerontol. 59 (2004) 172-177
2. Catella-Lawson F., Reilly M.P., Kapoor S.C., Cucchiara A.J., DeMarco S., Tournier B., Vyas S.N., and FitzGerald G.A. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N. Engl. J. Med. 345 (2001) 1809-1817
3. 50) of an enzymatic reaction. Biochem. Pharmacol. 22 (1973) 3099-3108
4. 2 receptors. J. Biol. Chem. 274 (1999) 14325-14330
5. Dorsam R.T., Kim S., Murugappan S., Rachoor S., Shankar H., Jin J., and Kunapuli S.P. Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways. Blood 105 (2005) 2749-2756
6. 2 receptors. Cell Signal. 16 (2004) 521-533
7. 2 synthase inhibitor enhanced antithrombotic efficacy of GPIIb-IIIa receptor antagonist without increasing bleeding. Eur. J. Pharmacol. 417 (2001) 217-222
8. 13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J. Cell Biol. 144 (1999) 745-754
9. McNicol A., and Israels S.J. Platelets and anti-platelet therapy. J. Pharmacol. Sci. 93 (2003) 381-396
10. 2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells. J. Immunol. 166 (2001) 617-623
11. Nagatome Y., Hirayama Y., Ito T., Ebihara S., and Watanabe Y. Effects of tea containing Hihatu (Piper longum) extract on cold constitution. J. Pharmacol. Sci. 97 (2005) 115
12. 2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein. Eur. J. Pharmacol. 162 (1989) 407-417
13. 2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets. Res. Commun. Mol. Pathol. Pharmacol. 87 (1995) 243-251
14. 2 and thrombin receptors in human platelets. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 504-508
15. q-deficient mice. Nature 389 (1997) 183-186
16. 2+pathway in rabbit platelets. Br. J. Pharmacol. 117 (1996) 1095-1104
17. 2 receptor in 1321N1 human astrocytoma cells. J. Pharmacol. Exp. Ther. 276 (1996) 829-836
18. q family. Trans. Assoc. Am. Physicians. 104 (1991) 11-20
19. Stoyioglou A., and Jaff M.R. Medical treatment of peripheral arterial disease: a comprehensive review. J. Vasc. Interv. Radiol. 15 (2004) 1197-1207
20. q/11and G β through its binding to ganglioside in lipid rafts. Mol. Pharmacol. 68 (2005) 1466-1474
21. 2 antagonist on sputum production and its physicochemical properties in patients with mild to moderate asthma. Chest 118 (2000) 73-79
22. i2 in phospholipid vesicles. Mol. Pharmacol. 46 (1994) 808-816
23. 2 release. J. Biol. Chem. 281 (2006) 30024-30035
24. Yang Y.C., Lee S.G., Lee H.K., Kim M.K., Lee S.H., and Lee H.S. A piperidine amide extracted from Piper longum L fruit shows activity against Aedes aegypti mosquito larvae. J. Agric. Food Chem. 50 (2002) 3765-3767