Exploring the structure-activity relationships of ABCC2 modulators using a screening approach

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3513-3525

  Wissel, Gloria ^a   Kudryavtsev, Pavel ^a   Ghemtio, Leo ^a   Tammela, Päivi ^a   Wipf, Peter ^c   Yliperttula, Marjo ^a   Finel, Moshe ^a   Urtti, Arto ^a,b   Kidron, Heidi ^a   Xhaard, Henri ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

ABC transporter; ABCC2; CDCF; Efflux; Estradiol glucuronide; Inhibitor; Membrane vesicles; Modulator MRP2; Sf9; Stimulator; Structure activity relationships; SVM modelling; Transport; Transport assay

Indexed keywords

BETA ESRADIOL 17 (BETA DELTA GLUCURONIDE); DICHLOROFLUORESCEIN; FLUORESCENT 5(6) CARBOXY 2',7' DICHLOROFLUORESCEIN; GLUCURONIDE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG; 5(6)-CARBOXY-2',7'-DICHLOROFLUORESCEIN; ESTRADIOL; ESTRADIOL-17 BETA-GLUCURONIDE; FLUORESCEIN DERIVATIVE; MOLECULAR LIBRARY; MOLECULAR PROBE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; RECOMBINANT PROTEIN;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; IC50; ISOTOPE LABELING; LIPOPHILICITY; MEMBRANE VESICLE; MOLECULAR PROBE; SCREENING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUPPORT VECTOR MACHINE; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SF9 CELL LINE; SPODOPTERA; TRANSPORT AT THE CELLULAR LEVEL; TRANSPORT VESICLE;

ANIMALS; BIOLOGICAL TRANSPORT; ESTRADIOL; FLUORESCEINS; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; MOLECULAR PROBES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECOMBINANT PROTEINS; SF9 CELLS; SMALL MOLECULE LIBRARIES; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPORT VESICLES;

EID: 84937390728     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.029     Document Type: Article

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